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1.
Summary The sex circle model for crossing over and gene conversion proposed by Stahl has a number of properties which are in conflict with a considerable body of recombination data in fungi. The model is unable to explain the observed frequencies of gene conversion and postmeiotic segregation for particular mutants in several species. It does not provide an explanation for fine structure map expansion, nor does it account satisfactorily for the polarised distribution of outside markers amongst allelic recombinants. 相似文献
2.
Gemma L. Moir-Meyer John F. Pearson Felicity Lose Rodney J. Scott Mark McEvoy John Attia Elizabeth G. Holliday Paul D. Pharoah Alison M. Dunning Deborah J. Thompson Douglas F. Easton Amanda B. Spurdle Logan C. Walker The Australian National Endometrial Cancer Study Group The Hunter Community Study Studies of Epidemiology Risk Factors in Cancer Heredity 《Human genetics》2015,134(3):269-278
3.
Alison E. Holliday Travis M. Mattingly Neil J. Holliday 《Physiological Entomology》2015,40(2):131-137
Secretions of an eversible gland on the metathorax of larvae of Chlaenius cordicollis Kirby (Coleoptera: Carabidae) are investigated by headspace analysis using solid phase microextraction followed by gas chromatography‐mass spectrometry (GC‐MS). Larvae from Manitoba, Canada and Pennsylvania, U.S.A., are sampled. Nine presumed defensive compounds are detected when the gland is everted, and this represents the first characterization of defensive secretions of larvae of a carabid beetle. With the exception of a single component (2‐methoxy‐4‐methylphenol), these compounds are distinct from those found in the defensive secretion of adult C. cordicollis. However, seven are more oxidized versions of the alkylphenolic compounds secreted by adult beetles: three hydroquinones (hydroquinone, methylhydroquinone and 2,3‐dimethylhydroquinone) and four quinones (p‐benzoquinone, toluquinone, 2,3‐dimethylquinone and ethyl‐p‐benzoquinone). An additional alkoxyphenol (2‐methoxy‐4‐ethylphenol) is also detected. Two patterns of composition are observed: in one, p‐benzoquinone and hydroquinone are undetectable and the ratio of toluquinone : 2,3‐dimethylquinone is 1 : 4.6 ± 0.6 (mean ± SE); in the other, all nine compounds are detectable and the ratio of toluquinone : 2,3‐dimethylquinone is 1 : 1.0 ± 0.2. These differences in pattern do not appear to be related to geographical source, sex or age of the larvae. 相似文献
4.
Frank D. Gunstone Janet A. Holliday Charles M. Scrimgeour 《Chemistry and physics of lipids》1977,20(4):331-335
The crystalline material which separates from Argemone mexicana seed oil is a mixture of 9-and 11-oxo-octacosanoic and 11-oxotriacontanoic acids. 相似文献
5.
6.
R Glaser E C Strain K L Tarr J E Holliday R L Donnerberg J K Kiecolt-Glaser 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1985,179(3):352-355
Antibody titers to the Epstein-Barr virus (EBV), early antigen (EA) IgG, and virus capsid antigen (VCA) IgG and IgA, were measured in 44 geriatric subjects to determine if the depression in cellular immunity known to be associated with aging affects the expression of latent EBV. Similar assays were performed on plasma obtained from a young adult (medical student) population as a control group. We found that 89% of the geriatric samples were positive for EA IgG, and 83% of the plasma obtained from medical students were positive for EA IgG. One hundred percent of the geriatric subjects were positive for VCA IgG, and 87% of the medical students were positive for VCA IgG. Seven percent of the medical student blood samples were positive for VCA IgA; in contrast, 36% of the blood samples obtained from the geriatrics subjects were positive. Significant differences were also found in the geometric mean titers (GMT) of antibodies to EBV antigens; the GMT to EBV EA and VCA were significantly higher in the geriatric group. The data suggest that there may be some loss of control over latent EBV by the cellular immune response in geriatric individuals. 相似文献
7.
Summary The biochemical defect in Bloom's syndrome (BS) remains unknown, but two characteristic features of BS cells point to a disturbance of DNA replication, namely, an excessive number of sister-chromatid exchanges (SCEs) in bromodeoxyuridine (BrdU)-substibuted cells and an abnormally slow rate of replicon elongation. The hypothesis of an abnormal DNA polymerase as the explanation for these observations was tested using an in situ assay system for DNA polymerase activity and to estimate molecular weights in cellular extracts of cultured BS cells. DNA polymerase subunits in cellular extracts from the BS cells when separated electrophoretically on polyacrylamide gels showed the same mobilities (i.e., molecular weights) as the controls and were equally effective at promoting the incorporation of isotopically labeled nucleosides. It is concluded that the genetic defect in BS has no direct effect on either DNA-polymerase activity or the amounts and molecular weights of the different forms of the enzyme. 相似文献
8.
The Induction of Mitotic Recombination by Mitomycin C in Ustilago and Saccharomyces 总被引:12,自引:2,他引:10 下载免费PDF全文
Robin Holliday 《Genetics》1964,50(3):323-335
9.
10.
In short-term field trials at combinations of ambient temperature (°C) and insolation (W·m−2), larval Colorado potato beetles (Leptinotarsa decemlineata [Say] [Coleoptera: Chrysomelidae]) were observed after their release on the adaxial surface of leaflets on potato plants
(Solanum tuberosum L. Solanaceae). The larvae either began feeding or moved under the leaflet; mean interval from release to expression of these
behaviors (2.9±0.05 min [n =358]) was independent of air temperature and insolation. Proportion of larvae moving under the
leaflet increased logistically with both air temperature and insolation. A 1 W·m−2 change in insolation (P) evoked the same effect on this proportion as a 0.0838 °C change in air temperature (T
a
), so the two quantities were combined as T*=T
a
+P·0.0838 °C/(W·m−2), which has units of °C. The proportion of larvae moving under the leaflet increased logistically with T*.
In 1-day field trials we monitored air temperature, insolation and proportion of larvae under the leaflet, and compared the
latter to predictions from the logistic regression derived from the short-term trials. Consistently more larvae occurred under
leaflets than predicted from the logistic regression; this bias diminished as T* increased until at T*≥40 °C, observed and predicted proportions were equal. This pattern of deviation from the predictions of the logistic regression
is consistent with a thermoregulatory strategy in which larvae move away from hostile conditions, rather than seek optimal
conditions. 相似文献