排序方式: 共有19条查询结果,搜索用时 15 毫秒
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Kota Asano Mitsumi Arito Manae S. Kurokawa Kazuki Omoteyama Kazuki Okamoto Naoya Suematsu Kazuo Yudoh Hiroshi Nakamura Moroe Beppu Tomohiro Kato 《Biochemical and biophysical research communications》2014
Layilin (LAYN) is thought to be involved in reorganization of cytoskeleton structures, interacting with merlin, radixin, and talin. Also, LAYN is known to be one of the receptors for hyaluronic acid (HA). 相似文献
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Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5 总被引:1,自引:0,他引:1
Pavri R Gazumyan A Jankovic M Di Virgilio M Klein I Ansarah-Sobrinho C Resch W Yamane A Reina San-Martin B Barreto V Nieland TJ Root DE Casellas R Nussenzweig MC 《Cell》2010,143(1):122-133
Activation-induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes; Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these transactions little is known about how AID finds its targets. We performed an shRNA screen to identify factors required for class switch recombination (CSR) of antibody loci. We found that Spt5, a factor associated with stalled RNA polymerase II (Pol II) and single stranded DNA (ssDNA), is required for CSR. Spt5 interacts with AID, it facilitates association between AID and Pol II, and AID recruitment to its Ig and non-Ig targets. ChIP-seq experiments reveal that Spt5 colocalizes with AID and stalled Pol II. Further, Spt5 accumulation at sites of Pol II stalling is predictive of AID-induced mutation. We propose that AID is targeted to sites of Pol II stalling in part via its association with Spt5. 相似文献
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Arito M Horiba T Hachimura S Inoue J Sato R 《The Journal of biological chemistry》2008,283(22):15224-15231
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Nakata A Haratani T Takahashi M Kawakami N Arito H Fujioka Y Shimizu H Kobayashi F Araki S 《Journal of human ergology》2001,30(1-2):203-209
A cross-sectional study was conducted to clarify the contribution of psychological job stress to insomnia in shift workers. A self-administered questionnaire concerning job stress, sleep, depressive symptoms and lifestyle factors was submitted to a sample of 530 rotating shift workers of age 18-59 years (mean age 27) in an electric equipment manufacturing company. Perceived job stress, i.e., job demands, job control and social support at work, was assessed using the Japanese version of the Job Content Questionnaire. Insomnia was regarded as prevalent if the workers had at least one of the following symptoms in the last year; less than 30 minutes to fall asleep, difficulty in maintaining sleep, or early morning awakening almost everyday. Overall prevalence was 37.8%. Logistic regression analyses while adjusting relevant factors showed that lower social support at work was significantly associated with a greater risk of insomnia than the higher social support (adjusted OR 2.5). Higher job strain with lower social support at work increased the risk, compared to lower strain with higher support at work (crude OR 1.8; adjusted OR 1.5). Our findings suggest the low social support at work independently associated with insomnia in shift workers. 相似文献
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Masaya Takahashi Heihachiro Arito 《European journal of applied physiology and occupational physiology》1994,68(3):274-280
The effects of a prolonged cognitive task prior to sleep onset on subsequent sleep patterns were examined in 14 healthy subjects who were randomly assigned to two conditions. Those assigned to a working condition were asked to engage in a prolonged cognitive task until close to bedtime (0200 hours), whereas those assigned to a relaxing condition were instructed to perform the same task during the daytime and then to stay awake in a relaxed state until the same bedtime as the work group. Visual scoring of sleep stages showed no significant differences in the amounts of stage 4 and slow wave sleep (stage 3+4) between the two conditions. Power spectrum analysis of sleep electroencephalogram (EEG) revealed that the EEG (0.5–4.0 Hz) power density in the first non-rapid eye movement (REM)-REM sleep cycle was significantly lower following the prolonged cognitive task prior to sleep onset than following the relaxed wakefulness and that the decreased EEG power density in the first sleep cycle was not compensated for during the later part of the sleep. These findings would indicate that the prolonged cognitive task prior to sleep onset may suppress EEG power density during subsequent sleep, suggesting that such a task may interfere with the development of deep non-REM sleep. 相似文献
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Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation 总被引:1,自引:0,他引:1
Kyong-Rim Kieffer-Kwon Zhonghui Tang Ewy Mathe Jason Qian Myong-Hee Sung Guoliang Li Wolfgang Resch Songjoon Baek Nathanael Pruett Lars Grøntved Laura Vian Steevenson Nelson Hossein Zare Ofir Hakim Deepak Reyon Arito Yamane Hirotaka Nakahashi Alexander L. Kovalchuk Jizhong Zou J. Keith Joung Vittorio Sartorelli Chia-Lin Wei Xiaoan Ruan Gordon L. Hager Yijun Ruan Rafael Casellas 《Cell》2013