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排序方式: 共有92条查询结果,搜索用时 15 毫秒
1.
Christina T. Fuentes Catarina Runa Xenxo Alvarez Blanco Verónica Orvalho Patrick Haggard 《PloS one》2013,8(10)
Despite extensive research on face perception, few studies have investigated individuals’ knowledge about the physical features of their own face. In this study, 50 participants indicated the location of key features of their own face, relative to an anchor point corresponding to the tip of the nose, and the results were compared to the true location of the same individual’s features from a standardised photograph. Horizontal and vertical errors were analysed separately. An overall bias to underestimate vertical distances revealed a distorted face representation, with reduced face height. Factor analyses were used to identify separable subconfigurations of facial features with correlated localisation errors. Independent representations of upper and lower facial features emerged from the data pattern. The major source of variation across individuals was in representation of face shape, with a spectrum from tall/thin to short/wide representation. Visual identification of one’s own face is excellent, and facial features are routinely used for establishing personal identity. However, our results show that spatial knowledge of one’s own face is remarkably poor, suggesting that face representation may not contribute strongly to self-awareness. 相似文献
2.
3.
AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey
Selliah RD Hellberg MR Sharif NA McLaughlin MA Williams GW Scott DA Earnest D Haggard KS Dean WD Delgado P Gaines MS Conrow RE Klimko PG 《Bioorganic & medicinal chemistry letters》2004,14(17):4525-4528
A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug of the potent agonist 13, lowered intraocular pressure in the monkey by 40% accompanied by minimal conjunctival hyperemia in the rabbit. AL-12182 was synthesized on multigram scale starting with D-sorbitol. 相似文献
4.
Roberto?H?Higa Roberto?C?Togawa Arnaldo?J?Montagner Juliana?CF?Palandrani Igor?KS?Okimoto Paula?R?Kuser Michel?EB?Yamagishi Adauto?L?Mancini Goran?NeshichEmail author 《BMC bioinformatics》2004,5(1):107
Background
The integration of many aspects of protein/DNA structure analysis is an important requirement for software products in general area of structural bioinformatics. In fact, there are too few software packages on the internet which can be described as successful in this respect. We might say that what is still missing is publicly available, web based software for interactive analysis of the sequence/structure/function of proteins and their complexes with DNA and ligands. Some of existing software packages do have certain level of integration and do offer analysis of several structure related parameters, however not to the extent generally demanded by a user. 相似文献5.
Research on sensory perception now often considers more than one sense at a time. This approach reflects real-world situations, such as when a visible object touches us. Indeed, vision and touch show great interdependence: the sight of a body part can reduce tactile target detection times [1], visual and tactile attentional systems are spatially linked [2], and the texture of surfaces that are actively touched with the fingertips is perceived using both vision and touch [3]. However, these previous findings might be mediated by spatial attention [1, 2] or by improved guidance of movement [3] via visually enhanced body position sense [4--6]. Here, we investigate the direct effects of viewing the body on passive touch. We measured tactile two-point discrimination thresholds [7] on the forearm while manipulating the visibility of the arm but holding gaze direction constant. The spatial resolution of touch was better when the arm was visible than when it was not. Tactile performance was further improved when the view of the arm was magnified. In contrast, performance was not improved by viewing a neutral object at the arm's location, ruling out improved spatial orienting as a possible account. Controls confirmed that no information about the tactile stimulation was provided by visibility of the arm. This visual enhancement of touch may point to online reorganization of tactile receptive fields. 相似文献
6.
Vestibular inputs are constantly processed and integrated with signals from other sensory modalities, such as vision and touch. The multiply-connected nature of vestibular cortical anatomy led us to investigate whether vestibular signals could participate in a multi-way interaction with visual and somatosensory perception. We used signal detection methods to identify whether vestibular stimulation might interact with both visual and somatosensory events in a detection task. Participants were instructed to detect near-threshold somatosensory stimuli that were delivered to the left index finger in one half of experimental trials. A visual signal occurred close to the finger in half of the trials, independent of somatosensory stimuli. A novel Near infrared caloric vestibular stimulus (NirCVS) was used to artificially activate the vestibular organs. Sham stimulations were used to control for non-specific effects of NirCVS. We found that both visual and vestibular events increased somatosensory sensitivity. Critically, we found no evidence for supra-additive multisensory enhancement when both visual and vestibular signals were administered together: in fact, we found a trend towards sub-additive interaction. The results are compatible with a vestibular role in somatosensory gain regulation. 相似文献
7.
Bevan KS Chung Suresh Selvarasu Andrea Camattari Jimyoung Ryu Hyeokweon Lee Jungoh Ahn Hongweon Lee Dong-Yup Lee 《Microbial cell factories》2010,9(1):50
Background
Pichia pastoris has been recognized as an effective host for recombinant protein production. A number of studies have been reported for improving this expression system. However, its physiology and cellular metabolism still remained largely uncharacterized. Thus, it is highly desirable to establish a systems biotechnological framework, in which a comprehensive in silico model of P. pastoris can be employed together with high throughput experimental data analysis, for better understanding of the methylotrophic yeast's metabolism. 相似文献8.
Previous studies have shown that the perceived times of voluntary actions and their effects are perceived as shifted towards each other, so that the interval between action and outcome seems shortened. This has been referred to as 'intentional binding' (IB). However, the generality of this effect remains unclear. Here we demonstrate that Intentional Binding also occurs in complex control situations. Using an aircraft supervision task with different autopilot settings, our results first indicated a strong relation between measures of IB and different levels of system automation. Second, measures of IB were related to explicit agency judgement in this applied setting. We discuss the implications for the underlying mechanisms, and for sense of agency in automated environments. 相似文献
9.
The effect of periphyton stoichiometry and light on biological phosphorus immobilization and release in streams 总被引:1,自引:0,他引:1
W. M. Drake J. Thad Scott Michelle Evans-White Brian Haggard Andrew Sharpley Chris W. Rogers Erin M. Grantz 《Limnology》2012,13(1):97-106
Periphyton stoichiometry can vary substantially as a result of differences in stream nutrient availability. A decrease in
the periphyton carbon to phosphorus (C:P) ratio should decrease the demand for new P to be immobilized from stream water,
but no studies to our knowledge have explored the relationship between periphyton stoichiometry and net P immobilization and
release by periphyton. We sought to model biological P immobilization and release (flux) in streams by measuring periphyton
stoichiometry and light availability. We measured P flux to and from intact periphyton on stream cobbles (20–100 mm diameter)
in 1 L microcosms incubated with streamwater under variable light conditions. Net P immobilization occurred in 75% of microcosms,
net P release occurred in only 5% of microcosms, and 20% of microcosms had neither net immobilization nor net release. When
normalized to stream conditions, net P immobilization was highest when light availability was high (<60% canopy attenuation)
and the periphyton C:P ratio was also high. In contrast, net P release occurred only when light availability was low (>60%
canopy attenuation) and the periphyton C:P ratio was also low. A multiple regression model that included both periphyton stoichiometry
and light availability from the growing season only, and the interaction term of these two variables, explained 99% of the
variation in daily periphyton P flux observed in the study. These results indicate that in order to predict periphyton P immobilization,
periphyton stoichiometry and light availability should be considered together. Furthermore, the results indicate that net
P immobilization occurs even in very P-rich periphyton, which can act as a P sink when light availability is high. 相似文献
10.