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排序方式: 共有202条查询结果,搜索用时 15 毫秒
1.
Reinout Heijungs Raymond R. Tan 《The International Journal of Life Cycle Assessment》2010,15(9):1014-1019
Background, aim, and scope
Propagation of parametric uncertainty in life cycle inventory (LCI) models is usually performed based on probabilistic Monte Carlo techniques. However, alternative approaches using interval or fuzzy numbers have been proposed based on the argument that these provide a better reflection of epistemological uncertainties inherent in some process data. Recent progress has been made to integrate fuzzy arithmetic into matrix-based LCI using decomposition into α-cut intervals. However, the proposed technique implicitly assumes that the lower bounds of the technology matrix elements give the highest inventory results, and vice versa, without providing rigorous proof. 相似文献2.
van Oers Lauran Guinée Jeroen B. Heijungs Reinout 《The International Journal of Life Cycle Assessment》2020,25(2):309-310
The International Journal of Life Cycle Assessment - The original version of this article unfortunately contained a mistake which was missed during typesetting. The caption to Fig. 5 was... 相似文献
3.
Prado Valentina Cinelli Marco Ter Haar Sterre F. Ravikumar Dwarakanath Heijungs Reinout Guinée Jeroen Seager Thomas P. 《The International Journal of Life Cycle Assessment》2020,25(12):2393-2406
The International Journal of Life Cycle Assessment - Weighting in life cycle assessment (LCA) incorporates stakeholder preferences in the decision-making process of comparative LCAs. Research... 相似文献
4.
Schauvliege R Vanrobaeys J Schotte P Beyaert R 《The Journal of biological chemistry》2002,277(44):41624-41630
5.
De Haes P Garmyn M Degreef H Vantieghem K Bouillon R Segaert S 《Journal of cellular biochemistry》2003,89(4):663-673
We investigated the capacity of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] to protect human keratinocytes against the hazardous effects of ultraviolet B (UVB)-irradiation, recognized as the most important etiological factor in the development of skin cancer. Cytoprotective effects of 1,25(OH)(2)D(3) on UVB-irradiated keratinocytes were seen morphologically and quantified using a colorimetric survival assay. Moreover, 1,25(OH)(2)D(3) suppressed UVB-induced apoptotic cell death. An ELISA, detecting DNA-fragmentation, demonstrated that pretreatment of keratinocytes with 1,25(OH)(2)D(3) 1 microM for 24 h reduced UVB-stimulated apoptosis by 55-70%. This suppression required pharmacological concentrations 1,25(OH)(2)D(3) and a preincubation period of several hours. In addition, 1,25(OH)(2)D(3) also inhibited mitochondrial cytochrome c release (90%), a hallmark event of UVB-induced apoptosis. Furthermore, we demonstrated that 1,25(OH)(2)D(3) reduced two important mediators of the UV-response, namely, c-Jun-NH(2)-terminal kinase (JNK) activation and interleukin-6 (IL-6) production. As shown by Western blotting, pretreatment of keratinocytes with 1,25(OH)(2)D(3) 1 microM diminished UVB-stimulated JNK activation with more than 30%. 1,25(OH)(2)D(3) treatment (1 microM) reduced UVB-induced IL-6 mRNA expression and secretion with 75-90%. Taken together, these findings suggest the existence of a photoprotective effect of active vitamin D(3) and create new perspectives for the pharmacological use of active vitamin D compounds in the prevention of UVB-induced skin damage and carcinogenesis. 相似文献
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7.
Reinout Heijungs Arjan de Koning Sangwon Suh Gjalt Huppes 《Journal of Industrial Ecology》2006,10(3):147-158
Integrated product policy, according to the European Union, requires reliable data on the impact of consumer products along their life cycles. We argue that this necessarily requires the development of an information tool for hybrid analysis, combining aspects of life-cycle assessment and input-output analysis. A number of requirements in the development of such a hybrid information tool are identified, mainly concerning data and computational structure. For the former, some important points of attention are discussed, whereas for the latter, operational formulas are developed. 相似文献
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9.
Raymond H J Staals Alfred W Bronkhorst Geurt Schilders Shimyn Slomovic Gadi Schuster Albert J R Heck Reinout Raijmakers Ger J M Pruijn 《The EMBO journal》2010,29(14):2358-2367
The exosome is an exoribonuclease complex involved in the degradation and maturation of a wide variety of RNAs. The nine‐subunit core of the eukaryotic exosome is catalytically inactive and may have an architectural function and mediate substrate binding. In Saccharomyces cerevisiae, the associated Dis3 and Rrp6 provide the exoribonucleolytic activity. The human exosome‐associated Rrp6 counterpart contributes to its activity, whereas the human Dis3 protein is not detectably associated with the exosome. Here, a proteomic analysis of immunoaffinity‐purified human exosome complexes identified a novel exosome‐associated exoribonuclease, human Dis3‐like exonuclease 1 (hDis3L1), which was confirmed to associate with the exosome core by co‐immunoprecipitation. In contrast to the nuclear localization of Dis3, hDis3L1 exclusively localized to the cytoplasm. The hDis3L1 isolated from transfected cells degraded RNA in an exoribonucleolytic manner, and its RNB domain seemed to mediate this activity. The siRNA‐mediated knockdown of hDis3L1 in HeLa cells resulted in elevated levels of poly(A)‐tailed 28S rRNA degradation intermediates, indicating the involvement of hDis3L1 in cytoplasmic RNA decay. Taken together, these data indicate that hDis3L1 is a novel exosome‐associated exoribonuclease in the cytoplasm of human cells. 相似文献
10.
Sensitivity coefficients for matrix-based LCA 总被引:2,自引:0,他引:2
Reinout Heijungs 《The International Journal of Life Cycle Assessment》2010,15(5):511-520