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de Queiroz João Vitor Vieira José Cavalcante Souza de Oliveira Grasieli Braga Camila Pereira da Cunha Bataglioli Izabela da Silva Janaína Macedo de Paula Araújo Wellington Luiz de Magalhães Padilha Pedro 《Biological trace element research》2019,187(1):291-300
Biological Trace Element Research - Predator fish can accumulate high levels of mercury, which qualifies them as potential indicators of this toxic metal. The predatory species Brachyplatystoma... 相似文献
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José Cavalcante Souza Vieira Camila Pereira Braga Grasieli de Oliveira Cilene do Carmo Federici Padilha Paula Martin de Moraes Luiz Fabricio Zara Aline de Lima Leite Marília Afonso Rabelo Buzalaf Pedro de Magalhães Padilha 《Biological trace element research》2018,181(1):164-172
Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) is a water-soluble organogermanium compound that exerts various physiological effects, including anti-inflammatory activity and pain relief. In water, Ge-132 is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGP), which in turn is capable of interacting with cis-diol compounds through its trihydroxy group, indicating that this compound could also interact with diol-containing nucleic acid constituents. In this study, we evaluated the ability of THGP to interact with nucleosides or nucleotides via nuclear magnetic resonance (NMR) analysis. In addition, we evaluated the effect of added THGP on the enzymatic activity of adenosine deaminase (ADA) when using adenosine or 2′-deoxyadenosine as a substrate. In solution, THGP indeed formed complexes with nucleotides or nucleosides through their cis-diol group. Moreover, the ability of THGP to form complexes with nucleotides was influenced by the number of phosphate groups present on the ribose moiety. Notably, THGP also inhibited the catalysis of adenosine by ADA in a concentration-dependent manner. Thus, interactions between THGP and important biological nucleic acid constituents might be implicated in the physiological effects of Ge-132. 相似文献
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de Queiroz João Vitor Vieira José Cavalcante Souza da Cunha Bataglioli Izabela Bittarello Alis Correia Braga Camila Pereira de Oliveira Grasieli do Carmo Federici Padilha Cilene de Magalhães Padilha Pedro 《Biological trace element research》2018,184(2):517-522
Biological Trace Element Research - This paper presents a slurry sampling method for total mercury determination by graphite furnace atomic absorption spectrometry (GFAAS) in tissue of fish from... 相似文献
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