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排序方式: 共有2421条查询结果,搜索用时 125 毫秒
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Haiyan Miao Jingjing Lu Yibing Guo Hongquan Qiu Yu Zhang Xihao Yao Xiaohong Li Yuhua Lu 《Journal of cellular and molecular medicine》2021,25(7):3654-3664
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and aggressive cancer that remains a major threat to human health across the globe. Despite advances in cancer treatments and diagnosis, the prognosis of PDAC patients remains poor. New and more effective PDAC therapies are therefore urgently required. In this study, we identified a novel host factor, namely the LncRNA TP73-AS1, as overexpressed in PDAC tissues compared to adjacent healthy tissue samples. The overexpression of TP-73-AS1 was found to correlate with both PDAC stage and lymph node metastasis. To reveal its role in PDCA, we targeted TP73-AS1 using LnRNA inhibitors in a range of pancreatic cancer (PC) cell lines. We found that the inhibition of TP73-AS1 led to a loss of MMP14 expression in PC cells and significantly inhibited their migratory and invasive capacity. No effects of TP73-AS1 on cell survival or proliferation were observed. Mechanistically, we found that TP73-AS1 suppressed the expression of the known oncogenic miR-200a. Taken together, these data highlight the prognostic potential of TP73-AS1 for PC patients and highlight it as a potential anti-PDAC therapeutic target. 相似文献
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Lin Xiang Lin Shuang Liu Yuanlan Zhao Haiyan Wang Li Hasi Wuliji 《Plasmonics (Norwell, Mass.)》2018,13(5):1749-1758
Plasmonics - Large-scale ordered two-dimensional (2D) superlattices at oil/water interface were fabricated using single-crystal Au nanospheres (NSs) with different diameters as building blocks. A... 相似文献
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不同利用方式下稻田效益的综合评价 总被引:1,自引:0,他引:1
一、引言评价是多目标系统优化和决策的基础。和任何其他农业生态系统一样,稻田生态系统具有多目标、多功能的特点,单项指标难以反映系统的优劣。目前,川东南地区稻田开发利用方式多种多样,但效益评价主要是采用简单的比较分析或粗放的定性描述,尚未形成系统的 相似文献
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R Takayanagi K Ohnaka Y Sakai R Nakao T Yanase M Haji T Inagami H Furuta D F Gou M Nakamuta 《Biochemical and biophysical research communications》1992,183(2):910-916
We isolated a cDNA encoding type-1 angiotensin II receptor from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 359 amino acid residues with a relative Mr of 41,060. The deduced amino acid sequence of the human angiotensin II (Ang II) receptor was 95.3% and 94.2% identical to those of bovine and rat type-1 Ang II receptors, respectively, and had a significant similarity with the G protein-coupled receptor. The rank order of the binding to the receptor expressed in COS-7 cells was Ang II greater than Ang III greater than Ang I. The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis. 相似文献
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油菜主序优势及其利用初析 总被引:2,自引:0,他引:2
油菜具有主序优势,主要表现在结角数上,在角粒数、千粒重及品质上也很显著。不同类型其优势强弱不同,白菜型和甘蓝型优势明显,芥菜型几乎不具有优势。在甘蓝型油菜中因品种、密度不同优势差异显著。增加密度可使主序在产量中的比例增加,在5万株/亩时可达73.05%.主序具有结角率高、成熟早等优点,通过选育优势强的品种,适当增加密度,合理调整布局,有望使油菜产量有较大幅度地提高 相似文献
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本文以O139死菌免疫健康家兔,经吸收去除非特异性凝集素制成的特异性诊断血清,专供诊断霍乱弧菌O139之用。采用玻片凝集试验对5株O139菌株及126株肠道菌进行验证,在敏感性和特异性方面均获得满意的结果。 相似文献
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Yun-Cheng Li Zi-Xi Gou Ze-Shen Liu Yue-Qin Tang Takashi Akamatsu Kenji Kida 《Biotechnology letters》2014,36(10):2011-2021
In the industrial production of bioethanol from lignocellulosic biomass, a strain of Saccharomyces cerevisiae that can ferment xylose in the presence of inhibitors is of utmost importance. The recombinant, industrial-flocculating S. cerevisiae strain NAPX37, which can ferment xylose, was used as the parent to delete the gene encoding p-nitrophenylphosphatase (PHO13) and overexpress the gene encoding transaldolase (TAL1) to evaluate the synergistic effects of these two genes on xylose fermentation in the presence of weak acid inhibitors, including formic, acetic, or levulinic acids. TAL1 over-expression or PHO13 deletion improved xylose fermentation as well as the tolerance of NAPX37 to all three weak acids. The simultaneous deletion of PHO13 and the over-expression of TAL1 had synergistic effects and improved ethanol production and reduction of xylitol accumulation in the absence and presence of weak acid inhibitors. 相似文献