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Meinzer U Esmiol-Welterlin S Barreau F Berrebi D Dussaillant M Bonacorsi S Chareyre F Niwa-Kawakita M Alberti C Sterkers G Villard C Lesuffleur T Peuchmaur M Karin M Eckmann L Giovannini M Ollendorff V Wolf-Watz H Hugot JP 《PloS one》2008,3(7):e2769
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice. 相似文献
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M L Genova E Bonacorsi M D'Aurelio G Formiggini B Nardo S Cuccomarino P Turi M M Pich G Lenaz C Bovina 《BioFactors (Oxford, England)》1999,9(2-4):345-349
In a surgical model of liver ischemia lipid peroxidation occurs, as shown by increase of lipid peroxidation end products, endogenous CoQ9 is oxidized and mitochondrial respiration is lowered; however, pre-treatment of the rats by i.p. injection of CoQ10 for 14 days normalizes the above parameters, presumably by way of the observed high extent of reduction of the incorporated quinone; moreover, liver homogenates of the CoQ10-treated rats are more resistant than those of non-treated rats to oxidative stress induced by an azido free radical initiator. This preliminary study suggests that CoQ10 pre-treatment can be of beneficial effect against oxidative damage during liver surgery transplantation. 相似文献
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Bidet P Metais A Mahjoub-Messai F Durand L Dehem M Aujard Y Bingen E Nassif X Bonacorsi S 《Applied and environmental microbiology》2007,73(7):2373-2377
Closely related Escherichia coli B2 strains O1:K1, O2:K1, O18:K1, and O45:K1 constitute a major subgroup causing extraintestinal infections. A DNA pathoarray analysis was used to develop a PCR specific for this subgroup that was included in the multiplex phylogenetic-grouping PCR method. Our PCR may serve to identify this virulent subgroup among different ecological niches. 相似文献
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Erick Denamur Stphane Bonacorsi Antoine Giraud Patrick Duriez Farida Hilali Christine Amorin Edouard Bingen Antoine Andremont Bertrand Picard Franois Taddei Ivan Matic 《Journal of bacteriology》2002,184(2):605-609
By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains. 相似文献
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Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo 总被引:1,自引:0,他引:1
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Mario Luppi Patrizia Barozzi Christine Morris Antonio Maiorana Richard Garber Goretta Bonacorsi Amedea Donelli Roberto Marasca Antonio Tabilio Giuseppe Torelli 《Journal of virology》1999,73(1):754-759
We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways. 相似文献
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A new O-antigen gene cluster has a key role in the virulence of the Escherichia coli meningitis clone O45:K1:H7
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Plainvert C Bidet P Peigne C Barbe V Médigue C Denamur E Bingen E Bonacorsi S 《Journal of bacteriology》2007,189(23):8528-8536
A new highly pathogenic clone of Escherichia coli meningitis strains harboring the unusual serogroup O45 has recently emerged in France. To gain insight into the pathogenicity of this new clone, we investigated the possible role of antigen O45 in the virulence of strain S88 (O45:K1:H7), representative of this emerging clone. We first showed that the S88 O-antigen gene cluster sequence differs from that of O45 in the reference strain E. coli 96-3285, suggesting that the two O45 polysaccharides, while probably sharing a community of epitopes, represent two different antigens. The unique functional organization of the two O-antigen gene clusters and the low DNA sequence homology of the orthologous genes suggest that the two loci originated from a common ancestor and have since undergone multiple recombination events. Phylogenetic analysis based on the flanking gene gnd sequences indicates that the S88 antigen O45 (O45S88) gene cluster may have been acquired, at least in part, from another member of the Enterobacteriaceae. Mutagenesis of the O45S88 antigen gene cluster was used for functional analysis of the loci and revealed the crucial role of the O polysaccharide in S88 virulence in a neonatal rat meningitis model. We also developed a PCR method to specifically identify the O45S88 antigen gene cluster. Together, our findings suggest that horizontal acquisition of a new O-antigen gene cluster, at least partly from another species, may have been a key event in the emergence and virulence of the E. coli O45:K1:H7 clone in France. 相似文献
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Detection and Identification by PCR of a Highly Virulent Phylogenetic Subgroup among Extraintestinal Pathogenic Escherichia coli B2 Strains
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Philippe Bidet Arnaud Metais Farah Mahjoub-Messai Lionel Durand Marie Dehem Yannick Aujard Edouard Bingen Xavier Nassif Stphane Bonacorsi 《Applied microbiology》2007,73(7):2373-2377
Closely related Escherichia coli B2 strains O1:K1, O2:K1, O18:K1, and O45:K1 constitute a major subgroup causing extraintestinal infections. A DNA pathoarray analysis was used to develop a PCR specific for this subgroup that was included in the multiplex phylogenetic-grouping PCR method. Our PCR may serve to identify this virulent subgroup among different ecological niches. 相似文献