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V Ia Glumov G S Ivanova E L Bazhenov 《Biulleten' eksperimental'no? biologii i meditsiny》1990,110(8):217-220
Dynamics and character of interrelations of destructive and reparative processes in the liver in different conditions of acute experimental peritonitis (AEP), using preparations, inhibiting or stimulating these reactions in the experiment with 135 white rats have been studied. It was established the dependence of the level of destruction and intensity of hepatic reparative regeneration on the gravity of peritoneum affection, the level of toxicity and the state of the body immunologic reactivity. The organ reparation in normal AEP in the first two days is carried out mainly by intercellular hyperplasia of hepatocyte ultrastructures. Karyokinetic cellular activity is increasing from the 3rd day and reacting its peak on the 4-5 day of the experiment. The course of peritonitis while introducing azathioprine is accompanied by prevailing destructive-purulent changes in the liver. On the contrary, levamisole administration in experimental animals causes an increase in lymphoid-cellular infiltration of stromal and parenchymatous cells with earlier reparation of necrotic foci. 相似文献
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Beliaev SS Borzenkov IA Nazina TN Rozanova EP Glumov IF Ibatullin RR Ivanov MV 《Mikrobiologiia》2004,73(5):687-697
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Randi T Garmo Steinar Waage Ståle Sviland Britt IF Henriksen Olav Østerås Olav Reksen 《Acta veterinaria Scandinavica》2010,52(1):11
Background
The objectives of this study were to investigate whether there were differences between Norwegian Red cows in conventional and organic farming with respect to reproductive performance, udder health, and antibiotic resistance in udder pathogens. 相似文献5.
Pramod Kumar Yadav Gurmit Singh Satendra Singh Budhayash Gautam Esmaiel IF Saad 《Bioinformation》2012,8(14):664-672
The emergence of multidrug-resistant strain of community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strain
has highlighted the urgent need for the alternative and effective therapeutic approach to combat the menace of this nosocomial
pathogen. In the present work novel potential therapeutic drug targets have been identified through the metabolic pathways
analysis. All the gene products involved in different metabolic pathways of CA-MRSA in KEGG database were searched against
the proteome of Homo sapiens using the BLASTp program and the threshold of E-value was set to as 0.001. After database
searching, 152 putative targets were identified. Among all 152 putative targets, 39 genes encoding for putative targets were
identified as the essential genes from the DEG database which are indispensable for the survival of CA-MRSA. After extensive
literature review, 7 targets were identified as potential therapeutic drug target. These targets are Fructose-bisphosphate aldolase,
Phosphoglyceromutase, Purine nucleoside phosphorylase, Uridylate kinase, Tryptophan synthase subunit beta, Acetate kinase and
UDP-N-acetylglucosamine 1-carboxyvinyltransferase. Except Uridylate kinase all the identified targets were involved in more than
one metabolic pathways of CA-MRSA which underlines the importance of drug targets. These potential therapeutic drug targets
can be exploited for the discovery of novel inhibitors for CA-MRSA using the structure based drug design (SBDD) strategy. 相似文献
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In the development of multicellularity, signaling proteins has played a very important role. Among them, RAS family is one of the
most widely studied protein family. However, evolutionary analysis has been carried out mainly on super family level leaving sub
family information in scanty. Thus, a subfamily evolutionary study on RAS evolutionary expansion is imperative as it will aid in
better drug designing against dreadful diseases like Cancer and other developmental diseases. The present study was aimed to
understand RAS evolution on both holistic as well as reductive level. All human RAS family genes and protein were subjected to
BLAST tools to find orthologs and paralogs with different parameters followed by phylogenetic tree generation. Our results clearly
showed that H-RAS is the most primitive RAS in higher eukaryotes and then diverged into other RAS family members due to
different gene modification events. Furthermore, a site specific selection pressure analysis was carried out using SELECTON server
which showed that H-RAS, M-RAS and N-RAS are evolving faster than K-RAS and R-RAS. Thus, the results ascertain a new
ground to cancer biologists to exploit negatively selected K-RAS and R-RAS as potent drug targets in cancer therapeutics. 相似文献
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Background
Breast cancer survivors, particularly those treated with chemotherapy, are at significantly increased risk for long-term cognitive and neurobiologic impairments. These deficits tend to involve skills that are subserved by distributed brain networks. Additionally, neuroimaging studies have shown a diffuse pattern of brain structure changes in chemotherapy-treated breast cancer survivors that might impact large-scale brain networks.Methods
We therefore applied graph theoretical analysis to compare the gray matter structural networks of female breast cancer survivors with a history of chemotherapy treatment and healthy age and education matched female controls.Results
Results revealed reduced clustering coefficient and small-world index in the brain network of the breast cancer patients across a range of network densities. In addition, the network of the breast cancer group had less highly interactive nodes and reduced degree/centrality in the frontotemporal regions compared to controls, which may help explain the common impairments of memory and executive functioning among these patients.Conclusions
These results suggest that breast cancer and chemotherapy may decrease regional connectivity as well as global network organization and integration, reducing efficiency of the network. To our knowledge, this is the first report of altered large-scale brain networks associated with breast cancer and chemotherapy. 相似文献8.
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