Mitochondrial Disorders in Alzheimer’s Disease

Biochemistry (Moscow) - Alzheimer’s disease is the most common age-related neurodegenerative disease. Understanding of its etiology and pathogenesis is constantly expanding. Thus, the...     

DNA aptamer-based sorbents for binding human IgE

DNA aptamer-based sorbents were synthesized for binding human IgE. Sorbents effectively removed IgE from human blood plasma. The experimental values of IgE desorption constants were within the range of 1.1 × 10^?10 to 1.7 × 10^?10 M depending on the orientation of the aptamer on an insoluble matrix. The sorbents were stable during multiple use. Conditions for sorbent regeneration were selected. These chromatographic materials can be used for medical and biotechnological applications.     

H3-dopamine and H3-quinuclidinylbenzilate binding by autonomic ganglia tissue in rats of various age

Binding of tritiated ligands of muscarinic and dopamine receptors was analysed in rats 1, 7, 14, 28, 60 days and 24-30 months old. The following ganglia were studied: the nodose ganglion, the lumbar ganglia of sympathetic chain, the main pelvic ganglion in male rats and the paracervical ganglion in female rats. The same level was found for binding of each of ligands for all investigated ganglia. Parameters of postnatal dynamics of development M-cholino- and dopamine reception systems prove to be quite similar, but not identical. Both of the systems reach matured level during first 2 postnatal weeks. In comparison with quinuclidinylbenzilate binding failure of dopamine binding in aged rats is to be more pronounced.     

Molecular Mechanisms of Interactions between Mitochondria and the Endoplasmic Reticulum: A New Look at How Important Cell Functions are Supported

Molecular Biology - Interactions between the endoplasmic reticulum (ER) and mitochondria have received insufficient attention until recently. However, distorted contacts between the ER and...     

Morphofunctional Assessment of Tissue Hypoxia Parameters in Lacunar Stroke in Humans

Human Physiology - Tissue hypoxia, developing as a consequence of vascular pathology, is a typical pathological process that underlies numerous disorders, including cerebrovascular disease. Hypoxic...