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Houpt ER Glembocki DJ Obrig TG Moskaluk CA Lockhart LA Wright RL Seaner RM Keepers TR Wilkins TD Petri WA 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(8):4496-4503
Amebic colitis is an important worldwide parasitic disease for which there is not a well-established animal model. In this work we show that intracecal inoculation of Entamoeba histolytica trophozoites led to established infection in 60% of C3H mice, while C57BL/6 or BALB/c mice were resistant, including mice genetically deficient for IL-12, IFN-gamma, or inducible NO synthase. Infection was a chronic and nonhealing cecitis that pathologically mirrored human disease. Characterization of the inflammation by gene chip analysis revealed abundant mast cell activity. Parasite-specific Ab and cellular proliferative responses were robust and marked by IL-4 and IL-13 production. Depletion of CD4(+) cells significantly diminished both parasite burden and inflammation and correlated with decreased IL-4 and IL-13 production and loss of mast cell infiltration. This model reveals important immune factors that influence susceptibility to infection and demonstrates for the first time the pathologic contribution of the host immune response in amebiasis. 相似文献
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Bezares Francisco J. Caldwell Joshua D. Glembocki Orest Rendell Ronald W. Feygelson Mariya Ukaegbu Maraizu Kasica Richard Shirey Loretta Bassim Nabil D. Hosten Charles 《Plasmonics (Norwell, Mass.)》2012,7(1):143-150
Periodic arrays of plasmonic nanopillars have been shown to provide large, uniform surface-enhanced Raman scattering (SERS)
enhancements. We show that these enhancements are the result of the combined impact of localized and propagating surface plasmon
modes within the plasmonic architecture. Here, arrays of periodically arranged silicon nanopillars of varying sizes and interpillar
gaps were fabricated to enable the exploration of the SERS response from two different structures; one featuring only localized
surface plasmon (LSP) modes and the other featuring LSP and propagating (PSP) modes. It is shown that the LSP modes determine
the optimal architecture, and thereby determine the optimum diameter for the structures at a given incident. However, the
increase in the SERS enhancement factor for a system in which LSP and PSP cooperatively interact was measured to be over an
order of magnitude higher and the peak in the diameter dependence was significantly broadened, thus, such structures not only
provide larger enhancement factors but are also more forgiving of lithographic variations. 相似文献
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