排序方式: 共有47条查询结果,搜索用时 15 毫秒
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Begunova A. V. Savinova O. S. Moiseenko K. V. Glazunova O. A. Rozhkova I. V. Fedorova T. V. 《Applied Biochemistry and Microbiology》2021,57(4):458-467
Applied Biochemistry and Microbiology - As a natural, symbiotic consortium of bacteria and yeasts, kefir grains provide a unique source of new probiotic microorganisms. In this work, three new... 相似文献
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S. A. Glazunova V. V. Ptushenko L. E. Gunar V. A. Karavaev M. K. Solntsev A. N. Tikhonov 《Biophysics》2009,54(3):343-344
Treatment of bean seedlings with a water extract of Reynoutria sachalinensis (giant knotweed) increases visible photosynthesis and the dark respiration of plants. The increase in CO2 uptake under intense illumination (10 000 lx) correlates with an increase in the fluorescence parameter (F
M − F
T)/F
T. 相似文献
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Andrey E. Shchekotikhin Valeria A. Glazunova Lyubov G. Dezhenkova Yuri N. Luzikov Yuri B. Sinkevich Leonid V. Kovalenko Vladimir N. Buyanov Jan Balzarini Fong-Chun Huang Jing-Jer Lin Hsu-Shan Huang Alexander A. Shtil Maria N. Preobrazhenskaya 《Bioorganic & medicinal chemistry》2009,17(5):1861-1869
We developed the synthesis of a series of thiophene-fused tetracyclic analogues of the antitumor drug ametantrone. The reactions included nucleophilic substitution of methoxy groups in 4,11-dimethoxyanthra[2,3-b]thiophene-5,10-diones with ethylenediamines, producing the derivatives of 4,11-diaminoanthra[2,3-b]thiophene-5,10-dione in good yields. Several compounds showed marked antiproliferative potency against doxorubicin-selected, P-glycoprotein-expressing tumor cells and p53?/? cells. The cytotoxicity of some novel compounds for P-glycoprotein-positive cells is highly dependent on N-substituent at the terminal amino group of ethylenediamine moiety. The cytotoxic potency of selected compounds correlated with their ability to attenuate the functions of topoisomerase I and telomerase, strongly suggesting that these enzymes are the major targets of antitumor activity of anthra[2,3-b]thiophene-5,10-dione derivatives. 相似文献
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Shchekotikhin AE Glazunova VA Luzikov YN Buyanov VN Susova OY Shtil AA Preobrazhenskaya MN 《Bioorganic & medicinal chemistry》2006,14(15):5241-5251
We describe the synthesis of derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione and their cytotoxicity for human tumor cells that express major determinants of altered anticancer drug response, the efflux pump P-glycoprotein, and non-functional p53. Nucleophilic substitution of methoxy groups in 4,11-dimethoxynaphtho[2,3-f]indole-5,10-dione with various ethylenediamines yielded the derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione, the indole containing analogues of the antitumor agent ametantrone. The cytotoxicity of novel compounds for multidrug resistant, P-glycoprotein-expressing tumor cells is highly dependent on the N-substituent at the terminal amino group of the ethylenediamine moiety. Whereas p53 null colon carcinoma cells were less sensitive to the reference drug doxorubicin than their counterparts with wild type p53, the majority of novel naphthoindole derivatives were equally potent for both cell lines, regardless of the p53 status. 相似文献
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Mallikarjun S Beelagi SR Santosh Kumar Uma Bharathi Indrabalan Sharanagouda S Patil Ashwini Prasad KP Suresh Shiva Prasad Kollur Veeresh Santhebennur Jayappa Siddappa B Kakkalameli Chandrashekar Srinivasa Prabhakarareddy Anapalli Venkataravana Chandan Shivamallu 《Bioinformation》2021,17(4):479
Crimean-Congo hemorrhagic fever (CCHF) virus is one among the major zoonosis viral diseases that use the Hyalomma ticks as their transmission vector to cause viral infection to the human and mammalian community. The fatality of infectious is high across the world especially in Africa, Asia, Middle East, and Europe. This study regarding codon usage bias of S, M, and L segments of the CCHF virus pertaining to the host Homo sapiens, reveals in-depth information about the evolutionary characteristics of CCHFV. Relative Synonymous Codon Usage (RSCU), Effective number of codons (ENC) were calculated, to determine the codon usage pattern in each segment. Correlation analysis between Codon adaptation index (CAI), GRAVY (Hydrophobicity), AROMO (Aromaticity), and nucleotide composition revealed bias in the codon usage pattern. There was no strong codon bias found among any segments of the CCHF virus, indicating both the factors i.e., natural selection and mutational pressure shapes the codon usage bias. 相似文献
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Paulo HG Mansur Lacordaire KP Cury José OB Leite Adriano A Pereira Nilson Penha-Silva Adriano O Andrade 《Biomedical engineering online》2010,9(1):29