排序方式: 共有73条查询结果,搜索用时 0 毫秒
1.
Beatriz Pereira Moreno Gislaine Cristiane Mantovanelli Letycia Lopes Ricardo Adriano Antnio Silva Rubem Silvrio De Oliveira Emy Luiza Ishii‐Iwamoto Maria Helena Sarragiotto Debora Cristina Baldoqui 《化学与生物多样性》2020,17(3)
Studies of the phytotoxic effects between plants can be a crucial tool in the discovery of innovative compounds with herbicide potential. In this sense, we can highlight ruzigrass (Urochloa ruziziensis), which is traditionally used in the crop rotation system in order to reduce weed emergence. The aim of this work was to characterize the secondary metabolites of ruzigrass and to evaluate its phytotoxic effects. In total, eight compounds were isolated: friedelin, oleanolic acid, α‐amyrin, 1‐dehydrodiosgenone, sitosterol and stigmasterol glycosides, tricin and p‐coumaric acid. Phytotoxic effects of the crude methanolic extract and fractions of ruzigrass were assessed using germination rate, initial seedling growth, and biomass of Bidens pilosa, Euphorbia heterophylla and Ipomoea grandifolia. Chemometric analysis discriminated the weed species into three groups, and B. pilosa was the most affected by fractions of ruzigrass. The phytotoxic activities of 1‐dehydrodiosgenone, tricin, and p‐coumaric acid are also reported, and p‐coumaric acid and 1‐dehydrodiosgenone were active against B. pilosa. 相似文献
2.
de Farias Bianca Xavier Costa Ana Beatriz Engel Nicole Alessandra de Souza Goldim Mariana Pereira da Rosa Turatti Cristini Cargnin-Cavalho Anderson Fortunato Jucélia Jeremias Petronilho Fabricia Jeremias Isabela Casagrande Rezin Gislaine Tezza 《Neurochemical research》2020,45(10):2487-2498
Neurochemical Research - Obesity is characterized by chronic inflammation of low grade. The cholinergic anti-inflammatory pathway favors the reduction of the inflammatory response. In this work the... 相似文献
3.
The illegal wildlife trade is one of the major threats to Brazil’s biodiversity. Approximately 80 % of illegally captured animals are birds, and 4 % of those are parrots. Although many seized birds do not survive, those that are recovered may be returned to the wild. The release of seized individuals into the wild should be conducted with caution, as local populations may suffer adverse effects if genetically different individuals are introduced. In this study, we evaluated the genetic relationships between 13 illegally captured blue-and-yellow macaws selected for release in northeastern Goiás, Brazil, and previously studied Brazilian macaw populations. We identified the seized macaws that were genetically similar to those from northwestern Goiás and that were therefore most suitable for release in that area. The genetic relationship was evaluated by sequence analysis of 403 bp of mitochondrial DNA control region. Relationships between mitochondrial haplotypes were computed via a median-joining network. Only six of the seized macaws were closely related to the macaws of northeastern Goiás, indicating that those macaws were potential candidates for release in that area. However, the release of these birds should follow all technical recommendations required by the Brazilian environmental authorities. 相似文献
4.
Ana O. Fagundes Maira R. Aguiar Claudia S. Aguiar Giselli Scaini Monique U. Sachet Nayara M. Bernhardt Gislaine T. Rezin Samira S. Valvassori João Quevedo Emilio L. Streck 《Neurochemical research》2010,35(11):1675-1680
Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works
regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of
chronic administration of methylphenidate on the activities of mitochondrial respiratory chain complexes I and III in the
brain of young rats. The effect of acute administration of methylphenidate on mitochondrial respiratory chain complexes I,
II, III and IV in the brain of young rats was also investigated. For acute administration, a single injection of methylphenidate
was given to rats on postnatal day 25. For chronic administration, methylphenidate injections were given starting at postnatal
day 25 once daily for 28 days. Our results showed that complexes I and III were not affected by chronic administration of
methylphenidate. Moreover, the acute administration of methylphenidate decreased complex I activity in cerebellum and prefrontal
cortex, whereas complexes II, III and IV were not altered. 相似文献
5.
Mitochondrial Dysfunction and Psychiatric Disorders 总被引:1,自引:0,他引:1
Mitochondrial oxidative phosphorylation is the major ATP-producing pathway, which supplies more than 95% of the total energy
requirement in the cells. Damage to the mitochondrial electron transport chain has been suggested to be an important factor
in the pathogenesis of a range of psychiatric disorders. Tissues with high energy demands, such as the brain, contain a large
number of mitochondria, being therefore more susceptible to reduction of the aerobic metabolism. Mitochondrial dysfunction
results from alterations in biochemical cascade and the damage to the mitochondrial electron transport chain has been suggested
to be an important factor in the pathogenesis of a range of neuropsychiatric disorders, such as bipolar disorder, depression
and schizophrenia. Bipolar disorder is a prevalent psychiatric disorder characterized by alternating episodes of mania and
depression. Recent studies have demonstrated that important enzymes involved in brain energy are altered in bipolar disorder
patients and after amphetamine administration, an animal model of mania. Depressive disorders, including major depression,
are serious and disabling. However, the exact pathophysiology of depression is not clearly understood. Several works have
demonstrated that metabolism is impaired in some animal models of depression, induced by chronic stress, especially the activities
of the complexes of mitochondrial respiratory chain. Schizophrenia is a devastating mental disorder characterized by disturbed
thoughts and perception, alongside cognitive and emotional decline associated with a severe reduction in occupational and
social functioning, and in coping abilities. Alterations of mitochondrial oxidative phosphorylation in schizophrenia have
been reported in several brain regions and also in platelets. Abnormal mitochondrial morphology, size and density have all
been reported in the brains of schizophrenic individuals. Considering that several studies link energy impairment to neuronal
death, neurodegeneration and disease, this review article discusses energy impairment as a mechanism underlying the pathophysiology
of some psychiatric disorders, like bipolar disorder, depression and schizophrenia. 相似文献
6.
Simone Molz Gislaine Olescowicz Jessica Rossana Kraus Fabiana Kalyne Ludka Carla I. Tasca 《Purinergic signalling》2015,11(1):117-126
Docosahexaenoic acid (DHA) is important for central nervous system function during pathological states such as ischemia. DHA reduces neuronal injury in experimental brain ischemia; however, the underlying mechanisms are not well understood. In the present study, we investigated the effects of DHA on acute hippocampal slices subjected to experimental ischemia by transient oxygen and glucose deprivation (OGD) and re-oxygenation and the possible involvement of purinergic receptors as the mechanism underlying DHA-mediated neuroprotection. We observed that cellular viability reduction induced by experimental ischemia as well as cell damage and thiobarbituric acid reactive substances (TBARS) production induced by glutamate (10 mM) were prevented by hippocampal slices pretreated with DHA (5 μM). However, glutamate uptake reduction induced by OGD and re-oxygenation was not prevented by DHA. The beneficial effect of DHA against cellular viability reduction induced by OGD and re-oxygenation was blocked with PPADS (3 μM), a nonselective P2X1–5 receptor antagonist as well as with a combination of TNP-APT (100 nM) plus brilliant blue (100 nM), which blocked P2X1, P2X3, P2X2/3, and P2X7 receptors, respectively. Moreover, adenosine receptors blockade with A1 receptor antagonist DPCPX (100 nM) or with A2B receptor antagonist alloxazine (100 nM) inhibited DHA-mediated neuroprotection. The addition of an A2A receptor antagonist ZM241385 (50 nM), or A3 receptor antagonist VUF5574 (1 μM) was ineffective. Taken together, our results indicated that neuroprotective actions of DHA may depend on P2X, A1, and A2B purinergic receptors activation. Our results reinforce the notion that dietary DHA may act as a local purinergic modulator in order to prevent neurodegenerative diseases. 相似文献
7.
A single dose of S‐ketamine induces long‐term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation 下载免费PDF全文
Gislaine Z. Réus Anelise S. Carlessi Stephanie E. Titus Helena M. Abelaira Zuleide M. Ignácio Jaine R. da Luz Beatriz I. Matias Livia Bruchchen Drielly Florentino Andriele Vieira Fabricia Petronilho João Quevedo 《Developmental neurobiology》2015,75(11):1268-1281
Ketamine, an antagonist of N‐methyl‐d ‐aspartate receptors, has produced rapid antidepressant effects in patients with depression, as well as in animal models. However, the extent and duration of the antidepressant effect over longer periods of time has not been considered. This study evaluated the effects of single dose of ketamine on behavior and oxidative stress, which is related to depression, in the brains of adult rats subjected to maternal deprivation. Deprived and nondeprived Wistar rats were divided into four groups nondeprived + saline; nondeprived + S‐ketamine (15 mg/kg); deprived + saline; deprived + S‐ketamine (15 mg/kg). A single dose of ketamine or saline was administrated during the adult phase, and 14 days later depressive‐like behavior was assessed. In addition, lipid damage, protein damage, and antioxidant enzyme activities were evaluated in the rat brain. Maternal deprivation induces a depressive‐like behavior, as verified by an increase in immobility and anhedonic behavior. However, a single dose of ketamine was able to reverse these alterations, showing long‐term antidepressant effects. The brains of maternally deprived rats had an increase in protein oxidative damage and lipid peroxidation, but administration of a single dose of ketamine reversed this damage. The activities of antioxidant enzymes superoxide dismutase and catalase were reduced in the deprived rat brains. However, ketamine was also able to reverse these changes. In conclusion, these findings indicate that a single dose of ketamine is able to induce long‐term antidepressant effects and protect against neural damage caused by oxidative stress in adulthood rats following maternal deprivation. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1268–1281, 2015 相似文献
8.
Helena M. Abelaira Gislaine Z. Réus Fabricia Petronilho Tatiana Barichello João Quevedo 《Neurochemical research》2014,39(9):1634-1639
Depression is a debilitating mental disease that affects a large number of people globally; however the pathophysiological mechanisms of this disease remain incompletely understood. Some studies have shown that depression is associated with inflammatory activity, and the mode of action of several antidepressants appears to involve immunomodulation. In this case, the induction of a pro-inflammatory state in healthy or depressive subjects induces a ‘sickness behaviour’ resembling depressive symptomatology. Potential mechanisms of pro-inflammatory cytokines are effects on monoamine levels, disruption of the hypothalamic–pituitary–adrenal axis, activation of the pathological microglial cells, such as the macrophages and alterations in neuroplasticity and brain functions. Thus, this review will highlight the role of inflammation in depression, the possible mechanisms involved, and also explore effective treatments that act on the immune system. 相似文献
9.
Custodio G Taques GR Figueiredo BC Gugelmin ES Oliveira Figueiredo MM Watanabe F Pontarolo R Lalli E Torres LF 《PloS one》2011,6(3):e18015
Background
Choroid plexus carcinomas (CPC) are rare tumors predominantly found in children. Given the high frequency of the germline R337H mutation in the TP53 gene in southern Brazil, we have evaluated the frequency of the R337H mutation in families with CPC in children.Methodology/Principal Findings
The present series included 29 patients that were admitted to the same institution from 1992 to 2010, including 22 children with CPC (0.08–13.6 years of age at diagnosis) and 7 children with papilloma of the choroid plexus (Pp; 0.5–9.8 years of age). Surgical resection was possible in 28 children. Blood and/or tumor DNA was extracted and analyzed using PCR-RFLP and results were confirmed by sequencing 240 bp of the TP53 exon 10. The patients, all parents, and some relatives submitted samples for blood DNA analysis. In addition, we have also examined the presence of the mutation in DNA from paraffin-embedded tumor samples to evaluate loss of heterozygosity. We found 63.3% (14/22) of the CPC patients positive for the germline R337H mutation; CPC samples were either heterozygous (n = 7), lost only the wild-type (n = 4), or only the R337H copy (n = 2). One CPC sample was not available. All Pp cases (7/7, 100%) were negative for R337H. Cure (>5 years survival free of disease) was observed in 18.1% of the CPC cases with the R337H mutation (2/11), 71.4% of the Pp (5/7), and 25% of CPC cases negative for the R337H mutation (2/8). Family history of cancer (with 2 or more cancer cases) was exclusively identified on the parental side segregating the R337H mutation, and 50% (7/14) of them were compatible with Li-Fraumeni-like syndrome.Significance
Our results show for the first time that the R337H TP53 mutation is responsible for 63% of the CPC cases in children, suggesting a higher incidence of CPC in southern Brazil. 相似文献10.
Piccinini Alexandre Oliveira Mariana Pacheco Silva Mariella Reinol Bett Gabriela Souza Becker Isabel Borges Mendes Talita Farias Salla Daniéle Hendler Silva Larissa Espindola Vilela Thais Ceresér Moraes Fernanda Mendes Moterle Diego Damiani Adriani Paganini Dagostin Lígia Salvan Tietbohl Lariani Tamires Bittencourt João Vitor Silvano Biehl Erica Denicol Tais Luise Bonfante Sandra Regina Andrade Vanessa Moraes Silveira Paulo Cesar Lock Prophiro Josiane Somariva Ferreira Gabriela Kozuchovski Petronilho Fabricia Kanis Luiz Alberto Rezin Gislaine Tezza 《Neurochemical research》2022,47(7):1888-1903
Neurochemical Research - This study aimed to evaluate the effect of Cynara cardunculus leaf ethanol extract on inflammatory and oxidative stress parameters in the hypothalamus, prefrontal cortex,... 相似文献