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Mobarra Naser Gholamalizadeh Hanieh Abdulhussein Kaed A. Raji Sara Taheri Asl Fatemeh Mirvahabi Mobina Sadat Rafiee Mahdi Pakzad Reza 《Molecular biology reports》2022,49(5):3657-3663
Molecular Biology Reports - This study explored the applicability of serum level and tissue expression of Ribonucleotide-diphosphate Reductase subunit M2 B (RRM2B) as reliable biomarkers for... 相似文献
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Saeid Doaei Sepideh Abdollahi Golsa Khalatbari Mohseni Maryam Gholamalizadeh Mohammad Esmail Akbari Seyed Mohammad Poorhosseini Seyedeh Elaheh Bagheri Soudeh GhafouriFard Ghasem Azizi Tabesh Alireza Moslem Naeemeh Hasanpour Ardekanizadeh Saeed Omidi Azita Hekmatdoost Mahdi Alam Rajabi Seyed Alireza Mosavi Jarrahi Mark O. Goodarzi 《Journal of cellular and molecular medicine》2022,26(23):5794
Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components. 相似文献
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Saeid Doaei Fatemeh Bourbour Samira Rastgoo Mohammad Esmail Akbari Maryam Gholamalizadeh Azadeh Hajipour Alireza Moslem Fereshteh Ghorat Mostafa Badeli Seyedeh Elaheh Bagheri Atieh Alizadeh Zohreh Mokhtari Samaneh Pishdad Sepehr JavadiKooshesh Ghasem Azizi Tabesh Fateme Montazeri Parvin Joola Shahla Rezaei Masoomeh Dorosti Seyed Alireza Mosavi Jarrahi 《Journal of cellular and molecular medicine》2021,25(7):3252-3257
Contradictory results were reported on the effect of fat mass- and obesity-associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case-control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms. 相似文献
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Maryam Gholamalizadeh Zohreh Mokhtari Saeid Doaei Vahideh Jalili Sayed Hossein Davoodi Mona Jonoush Mohammad Esmail Akbari Azadeh Hajipour Bojlul Bahar Ghasem Azizi Tabesh Saeed Omidi Seyed Alireza Mosavi Jarrahi 《Journal of cellular and molecular medicine》2021,25(20):9627-9633
The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross-sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra-primer amplification refractory mutation system (Tetra-ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme-linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer. 相似文献
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