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Carroll EA Gerrelli D Gasca S Berg E Beier DR Copp AJ Klingensmith J 《Developmental biology》2003,262(1):16-31
The axial midline is an important source of patterning and morphogenesis cues in the vertebrate embryo. The midline derives from a small group of cells in the gastrulating embryo, known as "the organizer" in recognition of its ability to organize an entire body plan. The mammalian organizer, the node, gives rise to axial midline structures: the notochord, dorsal foregut, and part of the floor plate of the neural tube. Only some of the genes that direct midline development are known. In this study, we present the complete coding sequence for a novel gene, cordon-bleu (cobl), expressed specifically in the node and its derivatives until organogenesis stages. The deduced sequence does not resemble any gene of known function. However, cobl is widely conserved: apparent orthologs and paralogs are found in many vertebrate species, with several sequence domains of high conservation but unknown function. We find that chicken cordon-bleu is similarly expressed in the node and its derivatives, suggesting functional conservation. We also report the sequence and nonoverlapping expression of a related mouse gene, Coblr1. Finally, we show that cobl interacts with the neurulation gene Vangl2 to facilitate midbrain neural tube closure, demonstrating roles for both cobl and Vangl2 in midbrain neurulation. 相似文献
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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. 总被引:29,自引:0,他引:29
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T M Saxton M Henkemeyer S Gasca R Shen D J Rossi F Shalaby G S Feng T Pawson 《The EMBO journal》1997,16(9):2352-2364
Shp-1, Shp-2 and corkscrew comprise a small family of cytoplasmic tyrosine phosphatases that possess two tandem SH2 domains. To investigate the biological functions of Shp-2, a targeted mutation has been introduced into the murine Shp-2 gene, which results in an internal deletion of residues 46-110 in the N-terminal SH2 domain. Shp-2 is required for embryonic development, as mice homozygous for the mutant allele die in utero at mid-gestation. The Shp-2 mutant embryos fail to gastrulate properly as evidenced by defects in the node, notochord and posterior elongation. Biochemical analysis of mutant cells indicates that Shp-2 can function as either a positive or negative regulator of MAP kinase activation, depending on the specific receptor pathway stimulated. In particular, Shp-2 is required for full and sustained activation of the MAP kinase pathway following stimulation with fibroblast growth factor (FGF), raising the possibility that the phenotype of Shp-2 mutant embryos results from a defect in FGF-receptor signalling. Thus, Shp-2 modulates tyrosine kinase signalling in vivo and is crucial for gastrulation during mammalian development. 相似文献
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From samples of deep-water zooplankton obtained in the Gulfof California, an undescribed species of the genus HyperocheBovallius was collected. The new species is similar to Hyperochemedusarum Kröyer and Hyperoche luetkenides Walker. It differsfrom its congeners mainly by the strong, large chela of pereopod2 and the absence of processes or denticles along the posteriordistal margin of same structure. It was collected at a depthof 1136 m as a symbiont of the bathypelagic hydromedusa Chromatonemaerythrogonon (Bigelow). The amphipod remained grasped to themedusa subumbrellar cavity. Seven other associations are knownbetween hyperiids and jellies in the Gulf of California, mostfrom the epipelagic layer. This is the only deep-living speciesof Hyperoche known. 相似文献
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José Ignacio Ruiz-Omeñaca José Ignacio Canudo Gloria Cuenca-Bescós Penélope Cruzado-Caballero José Manuel Gasca Miguel Moreno-Azanza 《Comptes Rendus Palevol》2012,11(6):435-444
A partially articulated postcranial skeleton of a small ornithischian dinosaur, Gideonmantellia amosanjuanae nov. gen. et sp., from the Early Cretaceous of Galve (Teruel province, Spain) is described. It was recovered in an outcrop of fluvial red clays from the Camarillas Formation, which is Barremian in age. This partial skeleton is recognised as a new ornithopod taxon by the following autapomorphies: (1) postacetabular process of the ilium with a brevis shelf that is noticeably medially expanded in its cranial part but narrow and horizontal in its caudal part; (2) rod-like prepubic process with its anterior end twisted and expanded; and (3) L-shaped first chevron. Our phylogenetic analysis indicates that Gideonmantellia represents a basal ornithopod taxon more derived than Orodromeus, the “Asian clade” (which includes Haya and others) and Hypsilophodon. 相似文献
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The composition, abundance and distribution of euphausiids from the southern part of the Mexican Caribbean Sea (August 1986) were sampled during the ARCOMM I cruise on board the R/V "Justo Sierra" of UNAM. Sampling was done using a Bongo-net (0.5 mm mesh size) performing oblique hauls from 200 m to the surface at 28 stations. Of the total euphausiid numbers, the most abundant species was Stylocheiron carinatum (49%), followed by Euphausia americana (9.8%) and E. tenera with (7.8%). The highest total density and that of the three most abundant species occurred during the night sampling, and probably was related to vertical migration patterns. The Bray-Curtis index revealed three station assemblages, related to the day-night variations of the euphausiid community. Species were distributed mainly in the oceanic area, and were absent in the neritic zones. The local fauna shows a strong affinity for the euphausiid community of the Gulf of Mexico and other areas of the Caribbean Sea. Four species are considered to be new records for the western Caribbean Sea. 相似文献
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First approximation to congenital malformation rates in embryos and hatchlings of sea turtles
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Seventy-one hyperiid species were identified from 97 zooplanktonsamples collected in the southern Gulf of Mexico during July1988. About 91% of the adult individuals belonged to five species:Lestrigonus bengalensis (86.56% of total hyperiid numbers),Anchylomera blossevillei (1.20%), Phronimopsis spinifera (1.05%),Hyperioides longipes (1.00%) and Hyperietta vosseleri (0.99%).Overall, up to 74% of the hyperiids were collected at night,although a reverse migration was observed in the anticyclones.The mean abundance was 5-fold higher at the neritic stationsthan in the oceanic areas. This tendency was even more markedat night. Night samples yielded about the same number of speciesas during the daytime (56 taxa versus 61). Four mesoscale features(two anticyclones, one cyclone and one upwelling) characterizedthe oceanic mesoscale circulation in the surveyed area. Theabundance of the oceanic hyperiid community showed significantdifferences related to some of the mesoscale features activein the area, i.e. the abundance in the Lazy Eddy anticyclonewas lower than that in the cyclone (day and night). Overall,the upwelling areas showed a tendency to have higher abundancesthan the downwelling features (anticyclones). Cluster analysisindicated neriticoceanic differences rather than mesoscalefeature-related differences in the local hyperiid community.The neritic community showed differences that were attributedto the effect of upwelling. The summer and spring hyperiid communitieshad important differences in the same area, thus suggestinga seasonal succession of the gulf hyperiid community. 相似文献