排序方式: 共有4条查询结果,搜索用时 78 毫秒
1
1.
2.
Zaalishvili GT Tsetskhladze ZR Margiani DO Gabriadze IIu Zaalishvili TM 《Molekuliarnaia biologiia》2005,39(2):317-320
Using DNA pulse field electrophoresis it has been shown that ADP-ribosylation in the nucleoids of human mononuclear leukocytes and rat brain cortex neurons stimulates cleavage of DNA loops at their attachmant sites to the nuclear matrix. The conclusion has been drawn suggesting possible participation of ADP-ribosylation in DNA-topoisomerase II activity modulation in the nuclear matrix of eukaryotic cells. 相似文献
3.
Zaalishvili TM Gabriadze IY Margiani DO Philauri VR Surguladze NM 《Biochemistry. Biokhimii?a》2000,65(6):659-661
The poly(ADP-ribose)-polymerase activity of brain and liver cell nuclei is changed during X-irradiation of rats. In the nuclear matrix, poly(ADP-ribose)-polymerase activity increases at a low dose of irradiation (1.7 Gy) and decreases at a high dose (6.7 Gy). A significant part of the activity of nuclear NMN-adenylyltransferase, a key enzyme for biosynthesis of NAD (the substrate of poly(ADP-ribose)-polymerase), has been found in the nuclear matrix. An interrelation between ADP-ribosylation taking place on the matrix level and eukaryotic cell DNA repair is suggested. 相似文献
4.
G. T. Zaalishvili Z. R. Tsetskladze D. O. Margiani I. Yu. Gabriadze T. M. Zaalishvili 《Molecular Biology》2005,39(2):281-283
Pulsed-field electrophoresis of DNA was used to demonstrate that ADP-ribosylation stimulates the cleavage of DNA loops at the sites of their anchorage to the nuclear matrix in nucleoids of human mononuclear leukocytes and rat brain neurons. ADP-ribosylation was assumed to play a role in regulating the activity of topoisomerase II in the nuclear matrix of eukaryotic cells.__________Translated from Molekulyarnaya Biologiya, Vol. 39, No. 2, 2005, pp. 317–320.Original Russian Text Copyright © 2005 by G. Zaalishvili, Tsetskladze, Margiani, Gabriadze, T. Zaalishvili. 相似文献
1