全文获取类型
收费全文 | 109篇 |
免费 | 13篇 |
出版年
2022年 | 1篇 |
2020年 | 1篇 |
2018年 | 1篇 |
2016年 | 7篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 5篇 |
2011年 | 9篇 |
2009年 | 3篇 |
2008年 | 4篇 |
2007年 | 3篇 |
2006年 | 3篇 |
2005年 | 9篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 7篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1980年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1970年 | 3篇 |
1966年 | 2篇 |
1962年 | 1篇 |
1914年 | 3篇 |
1913年 | 1篇 |
1912年 | 1篇 |
1911年 | 1篇 |
1909年 | 1篇 |
排序方式: 共有122条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms 总被引:15,自引:0,他引:15
Dong Z Venkatachalam MA Wang J Patel Y Saikumar P Semenza GL Force T Nishiyama J 《The Journal of biological chemistry》2001,276(22):18702-18709
6.
7.
Lee HY Srinivas H Xia D Lu Y Superty R LaPushin R Gomez-Manzano C Gal AM Walsh GL Force T Ueki K Mills GB Kurie JM 《The Journal of biological chemistry》2003,278(26):23630-23638
Cancer cells in which the PTEN lipid phosphatase gene is deleted have constitutively activated phosphatidylinositol 3-kinase (PI3K)-dependent signaling and require activation of this pathway for survival. In non-small cell lung cancer (NSCLC) cells, PI3K-dependent signaling is typically activated through mechanisms other than PTEN gene loss. The role of PI3K in the survival of cancer cells that express wild-type PTEN has not been defined. Here we provide evidence that H1299 NSCLC cells, which express wild-type PTEN, underwent proliferative arrest following treatment with an inhibitor of all isoforms of class I PI3K catalytic activity (LY294002) or overexpression of the PTEN lipid phosphatase. In contrast, overexpression of a dominant-negative mutant of the p85alpha regulatory subunit of PI3K (Deltap85) induced apoptosis. Whereas PTEN and Delta85 both inhibited activation of AKT/protein kinase B, only Deltap85 inhibited c-Jun NH2-terminal kinase (JNK) activity. Cotransfection of the constitutively active mutant Rac-1 (Val12), an upstream activator of JNK, abrogated Deltap85-induced lung cancer cell death, whereas constitutively active mutant mitogen-activated protein kinase kinase (MKK)-1 (R4F) did not. Furthermore, LY294002 induced apoptosis of MKK4-null but not wild-type mouse embryo fibroblasts. Therefore, we propose that, in the setting of wild-type PTEN, PI3K- and MKK4/JNK-dependent pathways cooperate to maintain cell survival. 相似文献
8.
9.
10.
Chlorophyll fluorescence measurements have a wide range of applications from basic understanding of photosynthesis functioning
to plant environmental stress responses and direct assessments of plant health. The measured signal is the fluorescence intensity
(expressed in relative units) and the most meaningful data are derived from the time dependent increase in fluorescence intensity
achieved upon application of continuous bright light to a previously dark adapted sample. The fluorescence response changes
over time and is termed the Kautsky curve or chlorophyll fluorescence transient. Recently, Strasser and Strasser (1995) formulated
a group of fluorescence parameters, called the JIP-test, that quantify the stepwise flow of energy through Photosystem II,
using input data from the fluorescence transient. The purpose of this study was to establish relationships between the biochemical
reactions occurring in PS II and specific JIP-test parameters. This was approached using isolated systems that facilitated
the addition of modifying agents, a PS II electron transport inhibitor, an electron acceptor and an uncoupler, whose effects
on PS II activity are well documented in the literature. The alteration to PS II activity caused by each of these compounds
could then be monitored through the JIP-test parameters and compared and contrasted with the literature. The known alteration
in PS II activity of Chenopodium album atrazine resistant and sensitive biotypes was also used to gauge the effectiveness and sensitivity of the JIP-test. The information
gained from the in vitro study was successfully applied to an in situ study. This is the first in a series of four papers. It shows that the trapping parameters of the JIP-test were most affected
by illumination and that the reduction in trapping had a run-on effect to inhibit electron transport. When irradiance exposure
proceeded to photoinhibition, the electron transport probability parameter was greatly reduced and dissipation significantly
increased. These results illustrate the advantage of monitoring a number of fluorescence parameters over the use of just one,
which is often the case when the FV/FM ratio is used.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献