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Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians
Ferjeni Zouidi Mouna Stayoussef Dorra Bouzid Hajer Fourati Olfa Abida M. Ben Ayed Thouraya Kammoun Monjia Hachicha Carlos Penha-Gonçalves Hatem Masmoudi 《Gene》2014
Type 1 diabetes (T1D) is caused by an immune-mediated destruction of the insulin-producing β-cells. Several studies support the involvement of T cell activation molecules. In order to underline the role of the genes involved in this pathway, we investigated, using the Sequenom MassARRAY platform, polymorphisms of sixteen single-nucleotide polymorphisms (SNPs) belonging to PTPN22, CD28, CTLA-4, and ZAP-70 genes in 76 T1D patients and 162 unrelated healthy controls from Southern Tunisia. 相似文献
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Ferjani Zouidi Mouna Stayoussef Dorra Bouzid Hajer Fourati Olfa Abida Costa João Mourad Ben Ayed Raouia Fakhfakh Kammoun Thouraya Hachicha Monjia Penha-Gonçalves Carlos Hatem Masmoudi 《Gene》2014
Type 1 diabetes (T1D) is an autoimmune disease (AID) with both genetic and environmental components. We aimed to investigate the genetic association of polymorphisms in genes previously linked with other AIDs, namely BANK1, IL15 and IL2/IL21 region. 相似文献
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