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Jun Wang Shenhai Gong Fangzhao Wang Mengwei Niu Guoquan Wei Zhanke He Tanwei Gu Yong Jiang Aihua Liu Peng Chen 《Biochemical and biophysical research communications》2019,508(4):1004-1010
Sepsis is a serious condition with a high mortality rate worldwide. Granisetron is an anti-nausea drug for patients undergoing chemotherapy. Here we aimed to identify the novel effect of granisetron on sepsis-induced acute lung injury (ALI). Our results showed that mice treated with granisetron displayed less severe lung damage than controls. Granisetron administration reduced pulmonary neutrophil recruitment after CLP. Moreover, the expressions of Cxcl1 and Cxcl2 were diminished in the presence of granisetron in THP-1 macrophages after lipopolysaccharide exposure. Additionally, granisetron could inhibit the activation of p38 MAPK and NLRP3 inflammasome both in vivo and in vitro. Collectively, granisetron protects against sepsis-induced ALI by suppressing macrophage Cxcl1/Cxcl2 expression and neutrophil recruitment in the lung. 相似文献
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Zhang Wanwan Chen Xiaoqi Yu Fangzhao Li Fengquan Li Wangdong Yi Meisheng Jia Kuntong 《中国病毒学》2021,36(6):1520-1531
Virologica Sinica - Viral hemorrhagic septicemia virus (VHSV), belonging to the genus Novirhabdovirus, Rhabdoviridae family, is a causative agent of high mortality in fish and has caused... 相似文献
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