全文获取类型
收费全文 | 407篇 |
免费 | 37篇 |
出版年
2021年 | 3篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 8篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 12篇 |
2014年 | 23篇 |
2013年 | 21篇 |
2012年 | 37篇 |
2011年 | 21篇 |
2010年 | 14篇 |
2009年 | 10篇 |
2008年 | 19篇 |
2007年 | 13篇 |
2006年 | 20篇 |
2005年 | 17篇 |
2004年 | 13篇 |
2003年 | 9篇 |
2002年 | 11篇 |
2001年 | 15篇 |
2000年 | 12篇 |
1999年 | 15篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1993年 | 6篇 |
1992年 | 10篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1969年 | 6篇 |
1967年 | 6篇 |
1966年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有444条查询结果,搜索用时 15 毫秒
1.
2.
C Fabre 《Hormones and behavior》1977,9(2):150-155
The complete behavioral repertoire of male sexual activity can be observed during daily androgen treatment (testosterone propionate, 15 mg/day) of normal ewes ovariectomized as adults. This includes the ejaculatory pattern (deep thrust accompanied by a rapid backwards movement of the head) which is followed by a dramatic decrease in the frequency of sexual interactions, similar to the male's postejaculatory reduction of activity. However, the sexual performances of the genetic females remain lower than those of normal males in ejaculation latency, postejaculation latency, and mount/ejaculation ratio. 相似文献
3.
Francis Fabre Nieve Magana-Schwencke Roland Chanet 《Molecular & general genetics : MGG》1989,215(3):425-430
Summary The RAD18 gene of Saccharomyces cerevisiae is involved in mutagenic DNA repair. We describe its isolation from a yeast library introduced into the centromeric YCp50 vector, a low copy number plasmid. The insert was sublconed into YCp50 and into the multicopy YRp7 plasmid. RAD18 is not toxic when present in multiple copies but the UV survival response indicates an heterogeneity in the cell population, a fraction of it being more sensitive. A DNA segment, close to RAD18, is toxic on the multicopy plasmid and may correspond to the tRAN sup61 known to be tightly linked to RAD18. Chromosomal deletions of RAD18 were constructed. The gene is not essential and the deleted strains have the properties of single site mutants. Thus, RAD18 appears to be essentially involved in DNA repair metabolism. 相似文献
4.
Sylviane Olschwang Richard Fabre Pierre Laurent-Puig Anne Vassal Bernard Hamelin Yusuke Nakamura Gilles Thomas 《Human genetics》1992,88(6):658-660
Summary The EF5.44 locus is in close proximity to the chromosome 5 region to which the genetic defect responsible for familial adenomatous polyposis has been mapped. We have devised two oligonucleotides that promote the specific polymerase chain reaction (PCR) amplificiation of a 365-bp sequence in this region. Analysis by denaturing gradient gel electrophoresis of the resulting fragment has unravelled individual differences that could be identified as a single base pair change in aMnlI restriction site. This PCR assayable polymorphism increases the informativeness at this locus, and should be useful in the presymptomatic diagnosis of familial adenomatous polyposis. 相似文献
5.
6.
7.
Résumé Le parasitePauesia cedrobii Stary et Leclant, spécifique du puceron du CèdreCedrobium laportei Remaudière, a été récolté dans le Moyen-Atlas, (Maroc) puis introduit dans un peuplement de cèdre (Cedrus atlantica Manetti) du sud-est de la France au printemps 1981. La méthode utilisée a consisté en une introduction directe des parasites,
préalablement isolés sur le lieu de récolte (momies) puis mis à éclore en chambre climatisée de fa?on à éliminer les hyperparasites.
Après accouplement, 225 adultes ont été introduits dans des manchons installés sur des rameaux abritant des colonies deC. laportei. L'évolution des populations de l'h?te et du parasite a été suivie au niveau des points de lacher d'une part, et dans la
parcelle d'autre part. L'installation définitive du parasite dans la parcelle s'est produite, 1 an après le lacher, grace
à un automne et à un hiver particulièrement doux, qui ont favorisé la multiplication de l'h?te. Le parasite est définitivement
implanté: il est encore présent 4 années après le lacher. Entre temps, il a été étendu à d'autres forêts de cèdre du sud-est
de la France. Huit espèces d'hyperparasites autochtones se sont portés surP. cedrobii, mais ceci ne remet pas en cause la réussite de l'introduction de l'aphidiide.
Avec la collaboration technique deE. Robert, A. Chalon, J. Chizky. 相似文献
8.
F. Fabre 《Molecular & general genetics : MGG》1971,110(2):134-143
Summary A high UV-sensitive mutant was obtained from a UV-sensitive strain of the yeast Schizosaccharomyces pombe after a mutagenic treatment. By genetic analysis, it was possible to distinguish two independent loci. The double mutant is supersensitive, that is more UV-sensitive than either of the two single mutants. This suggests that the mutations involved interfere with two repair pathways that are, at least partially, independent of each other.Some properties of the two single mutants were studied. These mutants differ notably in their response to caffeine, to liquid-holding, to exposure to visible light after UV irradiation, and in their UV-sensitive during the logarithmic growth phase.Comparison of the properties of the wild-type strain and of the different UV sensitive mutants leads to the conclusion that one repair pathway is used preferentially in the wild-type strain.Abbreviations DRF
dose reduction factor
- LH
liquid holding 相似文献
9.
a/α-Control of DNA Repair in the Yeast Saccharomyces Cerevisiae: Genetic and Physiological Aspects 总被引:1,自引:1,他引:0 下载免费PDF全文
It has long been known that diploid strains of yeast are more resistant to γ-rays than haploid cells, and that this is in part due to heterozygosity at the mating type (MAT) locus. It is shown here that the genetic control exerted by the MAT genes on DNA repair involves the a1 and α2 genes, in a RME1-independent way. In rad18 diploids, affected in the error-prone repair, the a/α effects are of a very large amplitude, after both UV and γ-rays, and also depends on a1 and α2. The coexpression of a and α in rad18 haploids suppresses the sensitivity of a subpopulation corresponding to the G(2) phase cells. Related to this, the coexpression of a and α in RAD(+) haploids depresses UV-induced mutagenesis in G(2) cells. For srs2 null diploids, also affected in the error-prone repair pathway, we show that their G(1) UV sensitivity, likely due to lethal recombination events, is partly suppressed by MAT homozygosity. Taken together, these results led to the proposal that a1-α2 promotes a channeling of some DNA structures from the mutagenic into the recombinational repair process. 相似文献
10.
Xrs2, a DNA Repair Gene of Saccharomyces Cerevisiae, Is Needed for Meiotic Recombination 总被引:7,自引:0,他引:7 下载免费PDF全文
The XRS2 gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that XRS2 also encodes an essential meiotic function. Spore inviability of xrs2 strains is rescued by a spo13 mutation, but meiotic recombination (both gene conversion and crossing over) is highly depressed in spo13 xrs2 diploids. The xrs2 mutation suppresses spore inviability of a spo13 rad52 strain suggesting that XRS2 acts prior to RAD52 in the meiotic recombination pathway. In agreement with the genetic data, meiosis-specific double-strand breaks at the ARG4 meiotic recombination hotspot are not detected in xrs2 strains. Despite its effects on meiotic recombination, the xrs2 mutation does not prevent mitotic recombination events, including homologous integration of linear DNA, mating-type switching and radiation-induced gene conversion. Moreover, xrs2 strains display a mitotic hyper-rec phenotype. Haploid xrs2 cells fail to carry out G2-repair of gamma-induced lesions, whereas xrs2 diploids are able to perform some diploid-specific repair of these lesions. Meiotic and mitotic phenotypes of xrs2 cells are very similar to those of rad50 cells suggesting that XRS2 is involved in homologous recombination in a way analogous to that of RAD50. 相似文献