全文获取类型
收费全文 | 3148176篇 |
免费 | 257994篇 |
国内免费 | 78274篇 |
出版年
2022年 | 27167篇 |
2021年 | 46003篇 |
2020年 | 33324篇 |
2019年 | 41155篇 |
2018年 | 48312篇 |
2017年 | 43072篇 |
2016年 | 60573篇 |
2015年 | 82454篇 |
2014年 | 100375篇 |
2013年 | 136307篇 |
2012年 | 151418篇 |
2011年 | 151629篇 |
2010年 | 104275篇 |
2009年 | 97723篇 |
2008年 | 130015篇 |
2007年 | 130555篇 |
2006年 | 122128篇 |
2005年 | 114374篇 |
2004年 | 108195篇 |
2003年 | 101810篇 |
2002年 | 96782篇 |
2001年 | 93977篇 |
2000年 | 94423篇 |
1999年 | 78474篇 |
1998年 | 39213篇 |
1997年 | 36160篇 |
1996年 | 34361篇 |
1995年 | 31900篇 |
1994年 | 30805篇 |
1993年 | 29430篇 |
1992年 | 62326篇 |
1991年 | 59959篇 |
1990年 | 58097篇 |
1989年 | 56663篇 |
1988年 | 53094篇 |
1987年 | 50333篇 |
1986年 | 47349篇 |
1985年 | 48668篇 |
1984年 | 42019篇 |
1983年 | 36553篇 |
1982年 | 30207篇 |
1981年 | 27502篇 |
1979年 | 38903篇 |
1978年 | 31308篇 |
1977年 | 28724篇 |
1976年 | 26843篇 |
1975年 | 29161篇 |
1974年 | 31528篇 |
1973年 | 30773篇 |
1972年 | 26735篇 |
排序方式: 共有10000条查询结果,搜索用时 468 毫秒
1.
2.
M Shadidy X Caubit R Olsen O M Seternes U Moens S Krauss 《Biochimica et biophysica acta》1999,1446(3):295-307
We have identified mouse and human FKBP60, a new member of the FKBP gene family. FKBP60 shares strongest homology with FKBP65 and SMAP. FKBP60 contains a hydrophobic signal peptide at the N-terminus, 4 peptidyl-prolyl cis/trans isomerase (PPIase) domains and an endoplasmic reticulum retention motif (HDEL) at the C-terminus. Immunodetection of HA-tagged FKBP60 in NIH-3T3 cells suggests that FKBP60 is segregated to the endoplasmic reticulum. Northern blot analysis shows that FKBP60 is predominantly expressed in heart, skeletal muscle, lung, liver and kidney. With N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as a substrate, recombinant GST-FKBP60 is shown to accelerate effectively the isomerization of the peptidyl-prolyl bond. This isomerization activity is inhibited by FK506. mFKBP60 binds Ca2+ in vitro, presumably by its C-terminal EF-hand Ca2+ binding motif, and is phosphorylated in vivo. hFKBP60 has been mapped to 7p12 and/or 7p14 by fluorescence in situ hybridization (FISH). 相似文献
3.
4.
5.
Squilla mantis hemocyanin is composed of two hexameric subunits but has electron microscopic profiles different from other bis-hexameric hemocyanins, e.g. Astacus and Homarus. We distinguished three different electron microscopic profiles of S. mantis hemocyanin: two sideviews and a topview. These profiles were studied using computer image alignment and correspondence analysis [Van Heel, M. and Frank, J. (1981) Ultramicroscopy 6, 187 - 194]. With the results of this analysis we were able to build a three-dimensional model for the quaternary structure of this hemocyanin. In this model the two hexamers are stacked in such a way that their hexagonal surfaces overlap to about 60% of their width. In the overlap area four subunits are arranged in two different interhexameric pairs, each forming a bridging area between the two hexamers. 相似文献
6.
7.
A patient with chronic anemia is presented who radiologically showed prominent rugae of the stomach. Angiography demonstrated an arteriovenous malformation with a large feeding artery and prominent draining veins. 相似文献
8.
9.
10.
Plant Molecular Biology - 相似文献