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1.
T. Finkenstädt N. T. Adler T. O. Allen S. O. E. Ebbesson J. -P. Ewert 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1985,156(4):433-445
Summary The (14C)2DG autoradiographic technique has been employed to quantitatively map glucose utilization in the mesencephalon, the diencephalon and the cerebellum, of toads in response to configurational moving visual stimuli: (i) a 0.4 cm × 2.8 cm worm-like stripe (W) which elicited prey catching responses, (ii) a 8.4 cm × 8.4 cm square (S) that released predator avoidance responses, and (iii) a 2.8 cm × 0.4 cm antiworm-like stripe (A) which elicited no motor activity.For various brain nuclei different relationships were obtained: The optic tectum showed statistical significant higher 2DG uptake during worm-stimulation (¯X
W) than during antiworm stimulation (¯X
A), i.e.¯X
W>¯X
A. The latter visual pattern led to a 2DG utilization that was statistically significant stronger than during stimulation with a square (¯X
S), i.e.¯X
A>¯X
S. Thus, in comparison between right and left hemisphere as well as between brains the following ratios were obtained:Optic tectum:¯X
W>¯X
A>¯X
S; nucleus isthmi:¯X
W>¯X
A-¯X
s; posterodorsal lateral thalamic nucleus:¯X
S>¯X
A>¯X
W; posteroventral lateral thalamic nucleus:¯X
S>¯X
A¯X
W; posterior thalamic nucleus:¯X
W>¯X
A¯X
S; anteripr division of the lateral thalamic nucleus:¯X
W>¯X
A¯X
S; anterior thalamic nucleus:¯X
A>¯X
S>¯X
W; nucleus of Bellonci and dorsal division of the ventrolateral thalamic nucleus:¯X
W¯X
A¯X
S; cerebellum:¯X
S¯X
W>¯X
A.Abbreviations
A
anterior thalamic nucleus
-
Cb
cerebellum
-
Hyp
hypothalamus
-
Ist
nucleus isthmi
-
cl. Ist
contralateral Ist
-
La
lateral thalamic nucleus, anterior division
-
Lpd
lateral thalamic nucleus, posterodorsal division
-
Lpv
lateral thalamic nucleus, posteroventral division
-
MP
medial pallium
-
NB/VLd
nucleus of Bellonci and ventrolateral thalamic nucleus, dorsal division
-
P
posterior thalamic nucleus
-
PO
preoptic area
-
Sna
snapping evoking area=ventrolateral tectum
-
Str
striatum
-
Tec
tectum opticum 相似文献
2.
3.
J. -P. Ewert H. -A. Häeter 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1969,64(2):135-153
Zusammenfassung Durch simultane visuelle Bewegungsreize, die von mehreren Beutetieren (z.B. Mehlkäferlarven) ausgehen, wird der Beutefang der Erdkröte (Bufo bufo L.) gehemmt. An diese Verhaltensheobaehtung anknüpfend, wurde die Abhängigkeit dieses inhibitorischen Umfeldeffektes von verschiedenen visuellen Reizparametern im Attrappen versuch quantitativ gemessen: Im frontalen Gesichtsfeld der Kröte rotierte vor dunklem Hintergrund eine weiße, rechteckige, 2,5 × 20° große Beuteattrappe (Zentralattrappe, z) mit dem Rechteckzentrum im Drehpunkt. Zusätzlich konnten mehrere Kreisscheiben von 5 bzw. 10° (Peripherattrappen, p) um die Zentralattrappe bewegt werden.Die Beutefangaktivität R
z [Beutefangreaktionen x min–1] auf die allein gebotene Zentralattrappe war bei einer Sehwinkelgeschwindigkeit v
s der distalen Attrappenkanten 10v
s30 [grad x see–1] maximal und sank für kleinere oder größere Winkelgeschwindigkeiten wieder ab.
Eine mit v
s=25 [grad x sec–1] allein bewegte Peripherattrappe löste maximale Beutefangaktivität R
p aus. Mit zunehmender Anzahl n
p simultan bewegter Peripherattrappen sank die Beutefangaktivität ab.Mehrere, um den gleichen Drehpunkt bewegte Peripherattrappen, deren Abstand untereinander
=10° betrug, blieben von der Kröte unbeantwortet. Sie bildeten ein inhibitorisches Umfeld und hemmten dadurch die Reaktion auf die gleichzeitig bewegte Zentralattrappe z. — Die im Simultanreizungsversuch gemessene Beutefangaktivität R
zp war abhängig vom Abstand
[grad] zwischen Zentralattrappe und Peripherattrappen (
: Kürzester Abstand zwischen z und p): Für
=10° war R
zp0 und stieg für
>10° an. — Kontrollversuche, die jeweils auf die Simultanreizung mit z allein folgten (R
z), ließen eine
-abhängige Nachhemmung erkennen. — Die hemmende Wirkung auf die Beantwortung von z war auch von der Sehwinkelgeschwindigkeit v
s der Peripherattrappen abhängig; sie war bei derjenigen Sehwinkelgeschwindigkeit (v
s=25 [grad × sec–1]) maximal, mit der die Zentralattrappe, allein geboten, maximale Beutefangaktivität auslöste; für v
sg25 [grad × sec–1] nahm die Hemmung wieder ab.Die Versuchsergebnisse lassen auf inhibitorische Verknüpfungen innerhalb des zentralen visuellen Systems schließen. Es wird vermutet, daß die Reiz-Verhaltens-reaktionsbeziehungen in den visuellen Simultanreizungsversuchen durch eine Art zentrale laterale Inhibition bestimmt werden.
Mit Unterstützung der Deutschen Forschungsgemeinschaft (Ew 7/4+5). 相似文献
Inhibitory effect of simultaneously moved prey dummies on the prey catching behaviour of the common toad (Bufo bufo L.)
Summary The prey catching behaviour of the toad (Bufo bufo L.) is generally inhibited by simultaneously visual moving stimuli caused by a group of prey animals (mealworms). According to this behavioural observation the dependence of this inhibitory effect on several visual parameters were quantitatively measured in dummy experiments: in the frontal visual field of the toad a white rectangular prey dummy of 2,5×20° (central dummy, z) was rotating in a centre against dark background. In addition several disks of 5 or 10° diameter (peripheral dummies, p) could simultaneously rotate around the central dummy (Figs. 1 and 7).The prey catching activity R z [catching reactions x min–1] released by rotation of only the central dummy z increased with increasing angular velocity v s of the stimulus distal edges, reaching a maximum for 10vs30 [degrees x sec–1] and decreasing for v s>30 [degrees x sec–1] (Fig. 5).A single peripheral dummy p, moved at v s=25 [degrees x sec–1], released maximal catching activity R p. The activity R p decreased with the increasing number n p of simultaneously offered dummies (Fig. 6).The prey catching behaviour of the toad was inhibited, when several peripheral dummies p were moved around the centre with a distance =10° from each other. They caused an inhibitory field and they also inhibited the response to a simultaneously moved central dummy z. The prey catching activity, measured in experiments in which z and p rotated simultaneously, depends on the distance [degrees] between z and p ( being the shortest distance between z and p). For =10°, R zp was zero; R zp increased for >10° (Figs. 9 and 10). — Control experiments carried out with z allone — after having applied the simultaneous stimulation — showed a - dependent after-inhibition (Fig. 9). — The inhibitory effect on the response to z also depended on the angular velocity v s of p; the inhibition was at a maximum for v s25 [degrees x sec–1], and it decreased for v s25 [degrees x sec–1] (Fig. 11).The experimental results suggest inhibitory interactions within the central visual system. It is supposed that the relation between stimulus and behavioural reaction in simultaneous stimulating experiments results from some kind of central nervous lateral inhibition.
Mit Unterstützung der Deutschen Forschungsgemeinschaft (Ew 7/4+5). 相似文献
4.
Jörg-Peter Ewert 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1967,57(3):263-298
Zusammenfassung In der vorliegenden Arbeit wurden die neurophysiologischen Grundlagen der taxisspezifischen Ermüdung beim Beutefang der Erdkröte (Bufo bufo L.) mit Hilfe von Hirnausschaltungen näher untersucht. Die Befunde wurden mathematisch-statistisch ausgewertet.Nach wiederholter Auslösung der Richtbewegung durch Reizung eines konstanten Retinabereiches mit einer bewegten Beuteattrappe sinkt die Reaktionsbereitschaft ab. Das Maß für die Bereitschaft ist die Anzahl vergeblicher Richtbewegungen dieser Reizserie. Innerhalb einer Reizserienfolge (mehrere Reizserien, getrennt durch Erholungspausen konstanter Dauer) zeigt die Abnahme der Reaktionsanzahlen je Reizserie einen exponentiellen, periodisch gedämpften Verlauf. Dem periodischen Ausschwingen der Reaktionsbereitschaft innerhalb einer Reizserienfolge kann die Verknüpfung von zwei Vorgängen zugrunde liegen: einem stetig abklingenden, exponentiellen, und einem periodischen Vorgang (Oszillation).Der exponentielle Verlauf läßt sich durch Variation der Erholungspausen ändern. Bei kurzen Erholungspausen sinken die Reaktionsanzahlen in aufeinanderfolgenden Reizserien schneller ab als bei langen Pausen.Durch triebbestimmende Faktoren, wie Jahreszeit, Tageszeit und Sättigungsgrad, läßt sich die allgemeine Reaktionshöhe verändern. Einflüsse auf den exponentiellen Verlauf konnten meistens nicht nachgewiesen werden.Nach partiellen Vorderhirnexstirpationen sinken die Reaktionsanzahlen im Verlauf der Reizserienfolge schneller als vor der Operation. Die Amplitude der Oszillation hat sich gegenüber den Normaltieren erhöht. Vorderhirnlose Kröten versagen beim Beutefang; das Fluchtverhalten bleibt jedoch erhalten.Nach Defekten im dorsalen Bereich des Zwischen- und des Mittelhirns (tammhirndefekte) vermindern sich die Reaktionsanzahlen innerhalb einer Reizserienfolge oft sehr viel langsamer als bei intakten Tieren. Amplitude, Frequenz und Dämpfung der Oszillation haben sich häufig verringert. Stammhirndefekte Kröten zeigen gesteigerte (enthemmte) Beutefangreaktionen. Sie schnappen nach beliebig großen, bewegten Gegenständen. Das Fluchtverhalten fällt aus. Je nach der Größe und der Lage des Defektes kann das Beuteverhalten selektiv für ein Auge, für beide Augen oder auch für getrennte Retinabereiche enthemmt werden. In gleicher Weise reagieren auch stammhirndefekte vorderhirnlose Kröten.Die taxisspezifische Ermüdung der Erdkröte (Bufo bufo L.) läßt sich als Folge einer reizspezifischen Nachwirkung deuten, die während einer Reizserie laufend zunimmt und die Ausführung der zugeordneten Reaktion hemmt. Das zentrale Wirkungsgefüge wird erörtert.
Zum Teil mit Unterstützung durch die Deutsche Forschungsgemeinschaft (Ew 7/1 a u. b und Ew 7/2). 相似文献
Investigations on central nervous actions to the taxis-specific fatigue in the prey-catching behaviour of the common toad (Bufo bufo L.)
Summary In the experiments described in the present paper, the author tried, by means of brain lesions to become nearer acquainted with the neurophysiological fundamentals of the taxis-specific fatigue in the prey-catching behaviour of the Common Toad (Bufo bufo L.). In statistical analyses, the results could be treated.When the release of the turning movements, by stimulating a constant part of the retina with a moving prey-dummy, is repeated, the responsiveness decreases (Fig. 4). Index of this responsiveness is the number of futile turning movements in a certain stimulus series. Within a sequence of series (several stimulus series separated by recovery intervals of constant duration), the decrease of response numbers in each series takes an exponential (Figs. 6 and 18 b normal), periodically (Figs. 6 and 18c normal) quenched course. This leads to the conclusion that an exponential process interferes with an oscillation.The exponential course can be altered by varying the recovery intervals. When the intervals are short, the response numbers decrease, in successive stimulus series, faster than when the pauses are long (Fig. 6).The general level of reaction can be changed by factors which determine the motivation, e.g. by season, temperature, and degree of satiation. Influences upon the exponential course could, mostly, not be ascertained.After the telencephalon has been partially extirpated, the response numbers diminish faster than before the operation (Figs. 10 and 11). The amplitude of the oscillation is higher than it is with normal individuals (Fig. 18a–c VH/E2 and VH/E3). Toads having no telencephalon fail to catch prey; the escape behaviour, however, is maintained.As a result of lesions in the dorsal regions of the diencephalon and mesencephalon (STH-lesions, Fig. 3), the response numbers often diminish, within a sequence of stimulus series, much slower than they do with intact animals (Fig. 12 STH/D1). Amplitude, frequency and quenching of the oscillation often have decreased (Fig. 19a–c Sth/D 1+VH). Toads operated in this way show excessive prey catching reactions. They snap at moving objects of whatever size (Fig. 15). The escape behaviour fails. According to the size and localization of the defect, the prey-catching behaviour can be intensified selectively for one eye, for both of them, or for separated parts of the retina. Toads defective in the dorsal regions of their diencephalon and mesencephalon (STH-lesion) and deprived of their telencephalon, react in the same manner (Figs. 13 and 20 STH/D1, 2-VH).The taxis-specific fatigue of Bufo bufo L. can be interpreted as a consequence of a stimulus-specific after-effect (Fig. 17), which increases continuously during a series of stimuli and inhibits the realization of the coordinated reaction. Finally, the author discusses the central meachnism (Fig. 16).
Zum Teil mit Unterstützung durch die Deutsche Forschungsgemeinschaft (Ew 7/1 a u. b und Ew 7/2). 相似文献
5.
Subunit selectivity and epitope characterization of mAbs directed against the GABAA/benzodiazepine receptor 下载免费PDF全文
M Ewert B D Shivers H Lüddens H M?hler P H Seeburg 《The Journal of cell biology》1990,110(6):2043-2048
mAbs bd 17, bd 24, and bd 28 raised against bovine cerebral gamma-aminobutyric acid (GABAA)/benzodiazepine receptors were analyzed for their ability to detect each of 12 GABAA receptor subunits expressed in cultured mammalian cells. Results showed that mAb bd 17 recognizes epitopes on both beta 2 and beta 3 subunits while mAb bd 24 is selective for the alpha 1 subunit of human and bovine, but not of rat origin. The latter antibody reacts with the rat alpha 1 subunit carrying an engineered Leu at position four, documenting the first epitope mapping of a GABAA receptor subunit-specific mAb. In contrast to mAbs bd 17 and bd 24, mAb bd 28 reacts with all GABAA receptor subunits tested but not with a glycine receptor subunit, suggesting the presence of shared epitopes on subunits of GABA-gated chloride channels. 相似文献
6.
Peter Richard Laming Jörg -Peter Ewert 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1984,154(1):89-101
Summary Visual unit activity, EEG changes and sustained potential shifts (SPS) were recorded from the toad tectum whilst the animal was presented with a visual stimulus. Telencephalic EEGs were also recorded.On the surface of the tectum, retinal unit activity preceded a sustained negative shift in potential and an increase in the amplitude and dominant frequency of the EEG. In deeper layers of the tectum, T5 units with configurational selectivity for wormlike stimuli were found. The activity of these units followed a pronounced SPS and EEG change.Visual unit activity was most pronounced during the negative-going phase of the synchronised EEG, when there was also a small decrease in amplitude of neuronal spikes. Similarities between the latencies and durations of EEGs and SPSs, and their response decrements, on repeated stimulus presentation, implies a close relationship between them not shared by the visual units studied. The specific activity of tectal units is discussed in relation to the correlated EEG and SPS changes, which may form part of an adaptive sensitizing mechanism.Abbreviations
EEG
electroencephalogram
-
ERF
excitatory receptive field
-
SPS
sustained potential shift
-
T4, T5
tectal neurons 相似文献
7.
Donald L. Ewert Douglas G. Gilmour W. Elwood Briles Max D. Cooper 《Immunogenetics》1980,10(1-4):169-174
Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens (Ia) and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the la antigens are determined by a single codominant locus and that theEa-B and Ia loci are on the same chromosome. Failure to detect a single recombinant between theEa-B and Ia loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The Ia genes are thus included in theB major histocompatibility complex of the chicken. 相似文献
8.
Genetics of Ia-like alloantigens in chickens and linkage with B major histocompatibility complex 总被引:2,自引:0,他引:2
Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens ("Ia") and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the "Ia" antigens are determined by a single codominant locus and that the Ea-B and "Ia" loci are on the same chromosome. Failure to detect a single recombinant between the Ea-B and "Ia" loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The "Ia" genes are thus included in the B major histocompatibility complex of the chicken. 相似文献
9.
Technique for determining total bacterial virus counts in complex aqueous systems. 总被引:4,自引:4,他引:0 下载免费PDF全文
A direct method is described for measuring bacteriophage concentrations in complex aqueous systems. Conditions for sample clarification, phage recognition, and recovery were optimized. In contrast to the plaque assay, this procedure permits quantitation of total numbers of phages independent of bacterial host. Also, the modifications increase the sensitivity of the sedimentation assay, permitting detection of particles at a minimum concentration of 10(4) per ml. Maximal total phage concentrations in the aqueous phase of sewage and activated sludge mixed liquor were 1.3 x 10(6) and 4.3 x 10(7) per ml, respectively. 相似文献
10.
Alloantisera raised in highly inbred lines of chickens, 7(2) and 15I(5) , by reciprocal immunization with lymphocytes were shown by immunofluorescence to react with B cells, cells of the monocyte-macrophage series, and an unidentified population of mononuclear cells prevalent in the spleen and bone marrow. Variable immunogenicity of the 'Ia'(2) and 'Ia'(15) alloantigens was observed. The alloantigens detected by these sara could be redistributed on the B-cell surface independently of immunoglobulin determinants or previously recognized antigens encoded by the major histocompatibility complex (B locus), and were more resistant to proteolysis than slgM. Analysis of several inbred lines of chickens revealed an association between expression of these antigens and the B haplotype. Strains of the B(2) haplotype expressed the antigen detected by anti-7 2 and vice versa. These data suggest that the B-cell alloantigens detected are encoded by genes linked to the MHC and may be analogous to la antigens of mice and DR antigens of man. 'Ia' alleles were co dominantly expressed on lymphocytes of F(1) hybrids. During ontogeny 'a'(+) cells were first detected in the bursa at 10 days of incubation , 3 days before 'Ia'(+). IgM(+) cells could be detected. Both 'Ia'(+).IgM(+) and 'Ia'(+).IgM(-) populations of bursal cells increased in parallel until day 18, when plateau levels were reached. Development of 'Ia'(+).IgM(-) cells throughout the body was unaffected by bursectomy at hatching. Cell surface expression of 'Ia' antigens was apparently increased with B-Iymphocyte maturation and was detectable on most, but not all, mature plasma cells. 相似文献