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Severi D. Ettouati L. Paris J. 《International journal of peptide research and therapeutics》2002,9(1):11-14
Summary The synthesis of 2-methyl-5-amino-4-oxo-3-sulfonyl esters, potential precursors of XaaΨ[COCH2]Ala, XaaΨ[E-CH=CH]Ala and XaaΨ[CH2CH2]Ala pseudodipeptides, has been investigated by alkylation of aminoacid-derived β-ketosulfones with ethyl 2-bromo- or 2-triflyloxypropionate
in different basic conditions. Yields in 2-methyl-5-amino-4-oxo-3-sulfonyl esters are low but starting β-ketosulfones are
recovered in good yield. 相似文献
2.
Koubeissi A Raad I Ettouati L Guilet D Dumontet C Paris J 《Bioorganic & medicinal chemistry letters》2006,16(21):5700-5703
Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins. 相似文献
3.
A rapid and versatile synthesis of 2-monosubstituted monosuccinates and their bimolecular anhydrides is described. The reaction of these anhydrides with N-Fmoc-protected dipeptides under the modified Dakin–West reaction affords mainly the corresponding 5-succinyloxyoxazoles. 相似文献
4.
Casimir Joseph Richard Ettouati Laurent Paris Joëlle 《International journal of peptide research and therapeutics》1998,5(1):13-18
Summary A rapid and versatile synthesis of 2-monosubstituted monosuccinates and their bimolecular anhydrides is described. The reaction
of these anhydrides withN-Fmoc-protected dipeptides under the modified Dakin-West reaction affords mainly the corresponding 5-succinyloxyoxazoles. 相似文献
5.
The synthesis of 2-methyl-5-amino-4-oxo-3-sulfonyl esters, potentialprecursors of Xaa[COCH2]Ala, Xaa[E-CH=CH]Ala andXaa[CH2CH2]Ala pseudodipeptides, has been investigated byalkylation of aminoacid-derived -ketosulfones with ethyl 2-bromo- or2-triflyloxypropionate in different basic conditions. Yields in 2-methyl-5-amino-4-oxo-3-sulfonyl esters are low but starting -ketosulfones are recovered in good yield. 相似文献
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