排序方式: 共有84条查询结果,搜索用时 125 毫秒
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Özaslan Ahmet Kayhan Gülsüm İşeri Elvan Ergün Mehmet Ali Güney Esra Perçin Ferda Emriye 《Molecular biology reports》2021,48(11):7371-7378
Molecular Biology Reports - Copy number variants (CNVs) play a key role in the etiology of autism spectrum disorder (ASD). Therefore, recent guidelines recommend chromosomal microarrays (CMAs) as... 相似文献
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Matić Ivana Z. Ergün Sercan Đorđić Crnogorac Marija Misir Sema Aliyazicioğlu Yüksel Damjanović Ana Džudžević-Čančar Hurija Stanojković Tatjana Konanç Kalbiye Petrović Nina 《Cytotechnology》2021,73(3):373-389
Cytotechnology - Six extracts were obtained from plant species Hypericum perforatum L., collected at Samsun in Turkey. The aim of this study was to examine the mechanisms of the anticancer activity... 相似文献
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Soner Kılıcaslan Mustafa Arslan Zeynep Ruya Çigdem Bilen Adem Ergün 《Journal of enzyme inhibition and medicinal chemistry》2016,31(6):1300-1305
Sulfonamide-bearing thiazole compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of the 12 synthesized sulfonamide (5a–l) on the hydratase and esterase activities of these isoenzymes (hCA-I and hCA-II) were studied in vitro. In relation to these activities, the inhibition equilibrium constants (Ki) were determined. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. Among them 5b was found to be the most active (IC50?=?0.35?μM; Ki: 0.33?μM) for hCA I and hCA II. 相似文献
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Banaz-Yaşar F Steffen G Hauschild J Bongartz BM Schumann GG Ergün S 《Histochemistry and cell biology》2010,134(6):581-589
Long interspersed nuclear element-1 (LINE-1, L1) is a retrotransposon which affects the human genome by a variety of mechanisms.
While LINE-1 expression is suppressed in the most somatic human cells, LINE-1 elements are activated in human cancer. Recently,
high accumulation of LINE-1-encoded ORF1p and ORF2p in endothelial cells of mature human blood vessels was described. Here,
we demonstrate that LINE-1 de novo retrotransposition events lead to a reduction of endothelial cell proliferation and migration
in a porcine aortic endothelial (PAE) cell model. Cell cycle studies show a G0/G1 arrest in PAE cells harboring LINE-1 de
novo retrotransposition events. Remarkably, in in situ analysis LINE-1-encoded ORF2p was not detectable in tumor blood vessels
of different human organs while vascular endothelial cells of corresponding normal organs strongly expressed LINE-1 ORF2p.
Quantitative RT-PCR analysis revealed that LINE-1 de novo retrotransposition influences selectively the expression of some
angiogenic factors such as VEGF and Tie-2. Thus, our data suggest that LINE-1 de novo retrotransposition events might suppress
angiogenesis and tumor vascularisation by reducing the angiogenic capacity of vascular endothelial cells. 相似文献
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Vincent D Ergül A Bohlman MC Tattersall EA Tillett RL Wheatley MD Woolsey R Quilici DR Joets J Schlauch K Schooley DA Cushman JC Cramer GR 《Journal of experimental botany》2007,58(7):1873-1892
The impact of water deficit and salt stress on two important wine grape cultivars, Chardonnay and Cabernet Sauvignon, was investigated. Plants were exposed to increasing salinity and water deficit stress over a 16 d time period. Measurements of stem water potentials, and shoot and leaf lengths indicated that Chardonnay was more tolerant to these stresses than Cabernet Sauvignon. Shoot tips were harvested every 8 d for proteomic analysis using a trichloroacetic acid/acetone extraction protocol and two-dimensional gel electrophoresis. Proteins were stained with Coomassie Brilliant Blue, quantified, and then 191 unique proteins were identified using matrix-assisted laser desorption ionization time of flight/time of flight mass spectrometry. Peptide sequences were matched against both the NCBI nr and TIGR Vitis expressed sequence tag (EST) databases that had been implemented with all public Vitis sequences. Approximately 44% of the protein isoforms could be identified. Analysis of variance indicated that varietal difference was the main source of protein expression variation (40%). In stressed plants, reduction of the amount of proteins involved with photosynthesis, protein synthesis, and protein destination was correlated with the inhibition of shoot elongation. Many of the proteins up-regulated in Chardonnay were of unclassified or of unknown function, whereas proteins specifically up-regulated in Cabernet Sauvignon were involved in protein metabolism. 相似文献
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Koç A Karaer K Ergün MA Cinaz P Perçin EF 《Genetic counseling (Geneva, Switzerland)》2007,18(3):325-330
Hairy Elbows Syndrome (Hypertrichosis Cubiti; OMIM# 139600) is a rare syndrome, and characterized by the presence of long vellus hair localized on the extensor surfaces of the distal third of the arms and proximal third of the forearm bilaterally. Occasionally hypertrichosis of other body regions may accompany hairy elbows. About half of the reported patients have short stature. Aside from short stature other relatively rare abnormalities related with this syndrome were also described. Most of the reported cases were sporadic, but autosomal dominant as well as autosomal recessive inheritance patterns have also been postulated. In this report, we present a girl with Hairy Elbows syndrome who has both characteristic and uncommon findings of the syndrome. She has excessive hair on her elbows, along with short stature, microcephaly, joint hyperlaxity, thin-long-webbed neck, dysmorphic facial features and mental retardation. 相似文献
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