全文获取类型
收费全文 | 5155篇 |
免费 | 378篇 |
出版年
2022年 | 31篇 |
2021年 | 93篇 |
2020年 | 41篇 |
2019年 | 56篇 |
2018年 | 78篇 |
2017年 | 63篇 |
2016年 | 135篇 |
2015年 | 250篇 |
2014年 | 262篇 |
2013年 | 323篇 |
2012年 | 375篇 |
2011年 | 342篇 |
2010年 | 234篇 |
2009年 | 195篇 |
2008年 | 280篇 |
2007年 | 278篇 |
2006年 | 259篇 |
2005年 | 269篇 |
2004年 | 268篇 |
2003年 | 223篇 |
2002年 | 205篇 |
2001年 | 52篇 |
2000年 | 46篇 |
1999年 | 53篇 |
1998年 | 68篇 |
1997年 | 56篇 |
1996年 | 49篇 |
1995年 | 59篇 |
1994年 | 53篇 |
1993年 | 48篇 |
1992年 | 35篇 |
1991年 | 43篇 |
1990年 | 34篇 |
1989年 | 37篇 |
1988年 | 39篇 |
1987年 | 36篇 |
1986年 | 31篇 |
1985年 | 31篇 |
1984年 | 35篇 |
1983年 | 23篇 |
1982年 | 19篇 |
1981年 | 24篇 |
1980年 | 21篇 |
1979年 | 27篇 |
1977年 | 31篇 |
1976年 | 23篇 |
1973年 | 15篇 |
1971年 | 15篇 |
1970年 | 15篇 |
1959年 | 14篇 |
排序方式: 共有5533条查询结果,搜索用时 281 毫秒
1.
2.
3.
L Theilmann L Teicher C S Schildkraut R J Stockert 《Biochimica et biophysica acta》1983,762(3):475-477
The expression of the hepatocellular membrane receptor for desialylated galactose-termining glycoproteins was studied during different proliferative stages of a human hepatoma cell line. Rapidly growing cells exhibited a reduced endocytotic rate of desialylated orsomucoid as compared to non-growing cells. This reduction was shown to be the consequence of a lower concentration of active cell-surface associated receptor protein in the dividing cells. 相似文献
4.
Elisabeth Hansson Ingemar Jacobson Richard Venema Åke Sellström 《Journal of neurochemistry》1980,34(3):569-573
Abstract: The lipophilic cation [3 H]triphenylrnethylphosphonium bromide ([3 H]TPMP+ ) was investigated as a measure of the membrane potential of synaptosomes. Conditions under which [3 H]TPMP+ achieved an equilibrium distribution were tested. The toxicity of TPMP has been studied relative to its inhibitory effects on [3 H]y-aminobutyric acid ([3 H]GABA) transport. In some experiments the distribution of 86 RbZ+ and [3 H]TPMP+ was changed upon incubation in the presence of elevated levels of K+ , ouabain, or KCN, or at 0°C in a way that would be expected from the membrane potential. In normal incubation conditions a membrane potential of ∼−60 mv was calculated. 相似文献
5.
Fixation with a saturated aqueous solution of potassium pyroantimonate produces electron-opaque antimonate deposits in the nucleoli of lutheinic and hepatic cells. The comparative analysis between normal and actinomycin D segregated nucleoli fixed either with glutaraldehyde-osmium or potassium pyroantimonate facilitates location of the ring-shaped precipitates in the fibrillar centers and the fine dense ones in the pars fibrosa. 相似文献
6.
Natan Medeiros Maciel Carlos Alberto Schwartz Guarino Rinaldi Colli Mariana Souza Castro Wagner Fontes Elisabeth N. Ferroni Schwartz 《Biochemical Systematics and Ecology》2006
This research tested the utility of two classes of skin secretion compounds to the phylogeny of the Bufo crucifer group. Skin secretions from specimens of nine populations of B. crucifer group were obtained and submitted to qualitative analysis. We observed a clear difference in the composition of the skin secretion molecules obtained from the species of Bufo studied. Fifty-nine molecules, 16 indolealkylamines and 43 proteins, were used as characters, and 39 of these were parsimonious informative. The tree topology of the skin secretion combined data showed areas of congruence and conflict when compared to an mtDNA phylogeny of the B. crucifer group. We used the Templeton test to evaluate the heterogeneity between the skin secretion and mtDNA data. Although not recommended, we performed a combined analysis with the two partitions. The skin secretion characters from the species of Bufo studied have phylogenetic signal. These data are indicative, at least as a preliminary study, of the phylogenetic relationships among the B. crucifer group taxa. 相似文献
7.
8.
R J Stockert A G Morell I H Scheinberg 《Biochemical and biophysical research communications》1976,68(3):988-993
Oligosaccharide chains of agalactoorosomucoid, α1-acid glycoprotein from which sialic acid and galactose have been sequentially removed, terminate in N-acetylglucosaminyl residues. This protein is rapidly transferred from the circulation into the liver by a route distinct from that previously demonstrated for a number of galactosyl terminating glycoproteins. 相似文献
9.
Yanyan Han Elfriede Eppinger Ingrid G. Schuster Luise U. Weigand Xiaoling Liang Elisabeth Kremmer Christian Peschel Angela M. Krackhardt 《The Journal of biological chemistry》2009,284(48):33409-33417
The formin protein formin-like 1 (FMNL1) is highly restrictedly expressed in hematopoietic lineage-derived cells and has been previously identified as a tumor-associated antigen. However, function and regulation of FMNL1 are not well defined. We have identified a novel splice variant (FMNL1γ) containing an intron retention at the C terminus affecting the diaphanous autoinhibitory domain (DAD). FMNL1γ is specifically located at the cell membrane and cortex in diverse cell lines. Similar localization of FMNL1 was observed for a mutant lacking the DAD domain (FMNL1ΔDAD), indicating that deregulation of autoinhibition is effective in FMNL1γ. Expression of both FMNL1γ and FMNL1ΔDAD induces polarized nonapoptotic blebbing that is dependent on N-terminal myristoylation of FMNL1 but independent of Src and ROCK activity. Thus, our results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells. 相似文献
10.
Elisabeth Vogl 《Plant Systematics and Evolution》1947,94(1-2):2-29
Ohne Zusammenfassung 相似文献