Deviation of eyes and head in acute cerebral stroke

Background  

It is a well-known phenomenon that some patients with acute left or right hemisphere stroke show a deviation of the eyes (Prévost's sign) and head to one side. Here we investigated whether both right- and left-sided brain lesions may cause this deviation. Moreover, we studied the relationship between this phenomenon and spatial neglect. In contrast to previous studies, we determined not only the discrete presence or absence of eye deviation with the naked eye through clinical inspection, but actually measured the extent of horizontal eye-in-head and head-on-trunk deviation. In further contrast, measurements were performed early after stroke onset (1.5 days on average).     

Microbiological exploitation of cardiac glycosides and alkaloids from Garcinia kola, Borreria ocymoides, Kola nitida and Citrus aurantifolia.

The four medicinal plants, Garcinia kola (roots), Borreria ocymoides (leaves), Kola nitida (bark) and Citrus aurantifolia (roots) were screened for phytochemical components. They were found to contain tannins, phlobatannins, polyphenols, hydroxymethyl anthraquinones, glucides, saponins, alkaloids, cardiac glycosides, flavanoids and reducing compounds. The aqueous and alcoholic extracts as well as alkaloids and cardiac glycosides of the medicinal plants were tested on various pathogenic bacteria. They were found to inhibit such organisms as Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, beta-haemolytic streptococci, Escherichia coli and Neisseria gonorrhoeae. The usefulness of the phytochemical bases of these plants as potential sources of pharmaceutical drug preparation is discussed.     

Impact of cocoa farming on vegetation in an agricultural landscape in Ghana

Cocoa production occurs almost wholly within areas identified as biodiversity hotspots in West Africa and it has been noted as a major contributor to deforestation at the forest‐agriculture interface. This study investigated the impact of cocoa farming on vegetation in relation to three land‐use types of increasing cocoa production intensity from remnant native forest through shaded to unshaded cocoa farmlands in Ghana. The study used transects and forty‐two 25 m × 25 m vegetation plots. The overall noncocoa plant species richness decreased significantly (95% CI) from the remnant native forest through shaded to the unshaded cocoa farmlands. Significant differences (P ≤ 0.05) were also found in the mean density and basal area of noncocoa plants per hectare with the remnant native forest recording the highest values and the unshaded cocoa farmlands the lowest. The relative density of about 44.7% out of the 41 most abundant plant species declined in cocoa farmlands. The results of this study showed that cocoa farming could result in a drastic forest plant species loss with subsequent recruitment of nonforest species, forest plant species population decline as well as changes in the structural characteristics of the vegetation. This impact increases with increasing cocoa production intensity.     

Correction: deviation of eyes and head in acute cerebral stroke

This is a correction article     

Patient characteristics that may predict the likelihood of the presence of mental health problems in patients attending the general outpatient clinic of a tertiary hospital in South-South Nigeria

Background A considerable number of patients seen in general outpatient clinics (GOPC) are known to suffer from psychiatric rather than physical disorders. Studies have shown that doctors working in these clinics have difficulty in making accurate ratings of mental health problems in their patients and have poor knowledge of psychiatric diagnosis. Accurate recognition of psychiatric symptoms in a patient is essential for specific diagnosis and successful management. There is a need for the use of an easy tool such as the12-item General Health Questionnaire (GHQ-12) for screening and identification of psychopathologies especially in a busy clinic setting like the GOPC. Aside from psychometric screening tools, patients' sociodemographic characteristics such as gender, age, marital status, occupation, education etc. have been found to be of value in predicting those at risk.Objectives This study seeks to correlate GHQ 'caseness' with sociodemographic factors and to compare physician diagnosis with GHQ diagnosis.Subjects and method Three-hundred and twenty-two respondents were recruited for the study by a systematic random sampling method. Using a cut off score of three on both the English and Efik translation versions of the GHQ-12, 'cases' and 'non-cases' generated were compared with the same classification as identified by the GOPC doctors. Identification rates for both groups were calculated and the coefficients determined using a two-by-two contingency table. Sociodemographic correlates were determined by statistical comparison of the classifications in both groups.Results Statistically significant differences in sociodemographic characteristics of respondents were found for age (χ(2)=48.97; P <0.05) and education (χ(2)=45.64; P=0.05) using their GHQ-12 scores, and for occupation (χ(2)=37.90; P <0.05) among those seen by the GOPC doctors. A further comparison of identified 'cases' and 'non-cases' by doctors again revealed significant difference for age (χ(2)=7.151; P <0.05). Sex as a sociodemographic characteristic showed no statistically significant difference though a greater percentage of females (57.3%) were observed as 'high scorers' as compared to their male counterparts (42.7%). The GHQ-12 identified 46.6% 'cases' while the GOPC doctors identified 6.8% among the attendees with a diagnostic sensitivity of 8% and a specificity of 94%, respectively.Conclusion Belonging to the 18-39 years age group, being employed and having less than 12 years of education were the patients' characteristics that suggested the likelihood of the presence of mental health problems.This study also revealed that despite the high proportion of psychiatric morbidity (46.6%) in the GOPC of the University of Calabar Teaching Hospital (UCTH) rate of detection by the clinic doctors was low (6.8%).It is recommended that primary care doctors should be alerted to the possibility that clinically significant psychiatric morbidity may be present in GOPC attendees. The correlation between patients' sociodemographic parameters and presence of mental health problems could be informative and should be given adequate attention during consultation.     

Semen quality and sperm output of Yankasa rams at different ages

Three groups of three Yankasa rams aged 1.4, 2.4, and 3.4 yr, weighing 32.8 +/- 0.8, 47.9 +/- 1.4, and 48.8 +/- 1.3 kg, and with scrotal circumferences measuring 26.8 +/- 0.9, 28.9 +/- 0.3, and 30.3 +/- 1.3 cm (mean +/- SEM), respectively, were used for this study. The rams were ejaculated once per day for 14 d using an artificial vagina and their semen quality and sperm output determined. For the three groups, ejaculate volume, sperm concentration, sperm motility, percentage of morphologically normal sperm, and total sperm output per ejaculate averaged 0.72 +/- 0.03, 0.90 +/- 0.04, and 0.88 +/- 0.03 ml; 3.421 +/- 0.133, 4.025 +/- 0.179, and 4.673 +/- 0.184 x 10(9)/ml; 83.2 +/- 2.3, 84.6 +/- 1.5, and 74.0 +/- 2.4%; 96.2 +/- 0.3, 96.0 +/- 0.4, and 95.4 +/- 0.4%; and 2.469 +/- 0.141, 3.663 +/- 0.237, and 4.163 +/- 0.247 x 10(9) sperm, respectively. Differences between groups were significant for all semen traits except for percentage of morphologically normal sperm. Total sperm output per ejaculate (Y; x 10(9)) was significantly correlated with scrotal circumference (X; cm) by the geometric regression equation Y = 0.000128 X(3.03) (r = 0.71; P < 0.05). Ejaculate characteristics were not influenced by day of collection except for percentage of morphologically normal sperm, which was significantly (P < 0.01) lower on the first day of collection.     

Microbiological exploitation of cardiac glycosides and alkaloids from Garcinia kola, Borreria ocymoides, Kola nitida and Citrus aurantifolia

R.U.B. EBANA, B.E. MADUNAGU, E.D. EKPE AND I.N. OTUNG. 1991. The four medicinal plants, Garcinia kola (roots), Borreria ocymoides (leaves), Kola nitida (bark) and Citrus aurantifolia (roots) were screened for phytochemical components. They were found to contain tannins, phlobatannins, polyphenols, pydroxymethyl anthraquinones, glucides, saponins, alkaloids, cardiac glycosides, flavanoids and reducing compounds. The aqueous and alcoholic extracts as well as alkaloids and cardiac glycosides of the medicinal plants were tested on various pathogenic bacteria. They were found to inhibit such organisms as Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa , β-haemolytic streptococci, Escherichia coli and Neisseria gonorrhoeae. The usefulness of the phytochemical bases of these plants as potential sources of pharmaceutical drug preparation is discussed.     

Itaconic acid derivatives and diketopiperazine from the marine-derived fungus Aspergillus aculeatus CRI322-03

Three metabolites, pre-aurantiamine (1), (−)-9-hydroxyhexylitaconic acid (4) and (−)-9-hydroxyhexylitaconic acid-4-methyl ester (5), together with two known compounds, paraherquamide E (6) and secalonic acid D (7), were isolated from the marine-derived fungus, Aspergillus aculeatus.