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Krystalia Lytra Ekaterina-Michaela Tomou Antonios Chrysargyris Maria-Dolores Christofi Panagiota Miltiadous Nikolaos Tzortzakis Helen Skaltsa 《化学与生物多样性》2021,18(3):e2000966
Sideritis cypria Post is an endemic and endangered species of Northern Cyprus. The overall aim of the present study was to evaluate the total phenolic content, the antioxidant, the cytotoxic and the antimicrobial activity of the methanol extract obtained from the aerial parts of cultivated S. cypria. A bio-guided approach led to the isolation of 27 chemical compounds by using various analytical techniques. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy. The crude extract exerted strong antioxidant activity (DPPH and FRAP assays) which was attributed to its high total phenolic content. Furthermore, groups rich in phenolic content showed highest antioxidant property, whereas groups with phytosterols, diterpenoids and apigenin derivatives exerted cytotoxic effects in MDA-MB231 cancer cell line by the MTT method. Moreover, the cytotoxic activity of four isolated apigenin derivatives was evaluated in the same cancer cells. The antimicrobial activity of the extract and groups were measured, demonstrating lack of activity. To the best of our knowledge, this survey is the first report on the biological activities of the methanol extract of S. cypria. 相似文献
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Tomou Ekaterina-Michaela Lytra Krystalia Rallis Stylianos Tzakos Andreas G. Skaltsa Helen 《Phytochemistry Reviews》2022,21(6):2049-2087
Phytochemistry Reviews - Genus Cistus L. (Cistaceae) occurs mainly in the Mediterranean region. Many plants of this genus have been used in different folk medicines since ancient times, mainly... 相似文献
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