排序方式: 共有98条查询结果,搜索用时 15 毫秒
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Samuel Gmez-Arcas Francisco Jos Muoz Adriana Ricarte-Bermejo ngela María Snchez-Lpez Marouane Baslam Edurne Baroja-Fernndez Abdellatif Bahaji Goizeder Almagro Nuria De Diego Karel Doleal Ondej Novk Jesús Leal-Lpez Rafael Jorge Len Morcillo Araceli G Castillo Javier Pozueta-Romero 《Plant physiology》2022,190(4):2137
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Pablo García-Gómez Abdellatif Bahaji Samuel Gámez-Arcas Francisco José Muñoz Ángela María Sánchez-López Goizeder Almagro Edurne Baroja-Fernández Kinia Ameztoy Nuria De Diego Lydia Ugena Lukáš Spíchal Karel Doležal Mohammad-Reza Hajirezaei Luis C. Romero Irene García Javier Pozueta-Romero 《Plant, cell & environment》2020,43(10):2551-2570
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Edurne Blanco Patricia Reglero Aurelio Ortega Arild Folkvord Fernando de la Gándara Alma Hernández de Rojas Marta Moyano 《Journal of fish biology》2020,97(5):1296-1305
Atlantic bluefin tuna is an iconic scombrid species with a high commercial and ecological value. Despite their importance, many physiological aspects, especially during the larval stages, are still unknown. Metabolic rates are one of the understudied aspects in scombrid larvae, likely due to challenges associated to larval handling before and during respirometry trials. Gaining reliable estimates of metabolic rates is essential to understand how larvae balance their high growth needs and activity and other physiological functions, which can be very useful for fisheries ecology and aquaculture. This is the first study to (a) estimate the relationship between routine metabolic rate (RMR) and larval dry weight (DW) (mass scaling exponent) at a constant temperature of 26°C, (b) measure the RMR under light and darkness and (c) test whether the interindividual differences in the RMR are related to larval nutritional status (RNA/DNA and DNA/DW). The RMR scaled nearly isometrically with body size (b = 0.99, 0.60–31.56 mg DW) in contrast to the allometric relationship observed in most fish larvae (average b = 0.87). The results show no significant differences in larval RMR under light and darkness, suggesting similar larval activity levels in both conditions. The size explained most of the variability in RMR (97%), and nutritional condition was unrelated to the interindividual differences in routine metabolism. This is the first study to report the metabolic rates of Atlantic bluefin tuna larvae and discuss the challenges of performing bioenergetic studies with early life stages of scombrids. 相似文献
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ángela María Sánchez-López Abdellatif Bahaji Nuria De Diego Marouane Baslam Jun Li Francisco José Mu?oz Goizeder Almagro Pablo García-Gómez Kinia Ameztoy Adriana Ricarte-Bermejo Ond?ej Novák Jan F. Humplík Luká? Spíchal Karel Dole?al Sergio Ciordia María Carmen Mena Rosana Navajas Edurne Baroja-Fernández Javier Pozueta-Romero 《Plant physiology》2016,172(3):1989-2001
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Rodríguez-Castillo Tamara Estévez Edurne González-Ferreras Alexia María Barquín José 《Ecosystems》2019,22(4):892-911
Ecosystems - River ecosystem metabolism (REM) is a promising cost-effective measure of ecosystem functioning, as it integrates many different ecosystem processes and is affected by both rapid... 相似文献
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Eydallin G Morán-Zorzano MT Muñoz FJ Baroja-Fernández E Montero M Alonso-Casajús N Viale AM Pozueta-Romero J 《FEBS letters》2007,581(23):4417-4422
AC70R1-504 Escherichia coli mutants possess a glgC* gene with a nucleotide change resulting in a premature stop codon that renders a truncated, inactive form of GlgC. Cells over-expressing the wild type glgC, but not those over-expressing the AC70R1-504 glgC*, accumulated high ADPglucose and glycogen levels. AC70R1-504 mutants accumulated glycogen, whereas DeltaglgCAP deletion mutants lacking the whole glycogen biosynthetic machinery displayed a glycogen-less phenotype. AC70R1-504 cells with enhanced glycogen synthase activity accumulated high glycogen levels. By contrast, AC70R1-504 cells with high ADPG hydrolase activity accumulated low glycogen. These data further confirm that enterobacteria possess various sources of ADPglucose linked to glycogen biosynthesis. 相似文献
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Morán-Zorzano MT Viale AM Muñoz FJ Alonso-Casajús N Eydallín GG Zugasti B Baroja-Fernández E Pozueta-Romero J 《FEBS letters》2007,581(5):1035-1040
Escherichia coli ADP-sugar pyrophosphatase (AspP) is a "Nudix" hydrolase that catalyzes the hydrolytic breakdown of ADP-glucose linked to glycogen biosynthesis. Moderate increases of AspP activity in the cell are accompanied by significant reductions of the glycogen content. In vitro analyses showed that AspP activity is strongly enhanced by macromolecular crowding and by both glucose-1,6-bisphosphate and nucleotide-sugars, providing a first set of indicative evidences that AspP is a highly regulated enzyme. To our knowledge, AspP is the sole bacterial enzyme described to date which is activated by both G1,6P(2) and nucleotide-sugars. 相似文献
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Iigo Apaolaza Edurne San Jos-Enriz Luis V. Valcarcel Xabier Agirre Felipe Prosper Francisco J. Planes 《PLoS computational biology》2022,18(3)
Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has limited effect in cell viability but inactivation of both genes simultaneously leads to cell death. Given the profound genomic aberrations acquired by tumor cells, which can be systematically identified with -omics data, SL is a promising concept in cancer research. In particular, SL has received much attention in the area of cancer metabolism, due to the fact that relevant functional alterations concentrate on key metabolic pathways that promote cellular proliferation. With the extensive prior knowledge about human metabolic networks, a number of computational methods have been developed to predict SL in cancer metabolism, including the genetic Minimal Cut Sets (gMCSs) approach. A major challenge in the application of SL approaches to cancer metabolism is to systematically integrate tumor microenvironment, given that genetic interactions and nutritional availability are interconnected to support proliferation. Here, we propose a more general definition of SL for cancer metabolism that combines genetic and environmental interactions, namely loss of gene functions and absence of nutrients in the environment. We extend our gMCSs approach to determine this new family of metabolic synthetic lethal interactions. A computational and experimental proof-of-concept is presented for predicting the lethality of dihydrofolate reductase (DHFR) inhibition in different environments. Finally, our approach is applied to identify extracellular nutrient dependences of tumor cells, elucidating cholesterol and myo-inositol depletion as potential vulnerabilities in different malignancies. 相似文献