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Gold salts and phenylbutazone selectively inhibit the synthesis of PGF2α and PGE2 respectively. Lowered production of one prostaglandin species is accompanied by an increased production of the other. Selective inhibition by these drugs was observed in the presence of adrenaline, reduced glutathione and copper sulphate under conditions when most anti-inflammatory compounds inhibited PGE2 and PGF2α syntheses equally. It is postulated that selective inhibitors may have a different mode of action
and beneficial effects may be related to the endogenous ratio of PGE to PGF required for normal function. 相似文献
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Chen Wu Cecilia Deng Elena Hilario Nick W. Albert Declan Lafferty Ella R. P. Grierson Blue J. Plunkett Caitlin Elborough Ali Saei Catrin S. Günther Hilary Ireland Alan Yocca Patrick P. Edger Laura Jaakola Katja Karppinen Adrian Grande Ritva Kylli Veli-Pekka Lehtola Andrew C. Allan Richard V. Espley David Chagn 《Molecular ecology resources》2022,22(1):345-360
Bilberry (Vaccinium myrtillus L.) belongs to the Vaccinium genus, which includes blueberries (Vaccinium spp.) and cranberry (V. macrocarpon). Unlike its cultivated relatives, bilberry remains largely undomesticated, with berry harvesting almost entirely from the wild. As such, it represents an ideal target for genomic analysis, providing comparisons with the domesticated Vaccinium species. Bilberry is prized for its taste and health properties and has provided essential nutrition for Northern European indigenous populations. It contains high concentrations of phytonutrients, with perhaps the most important being the purple colored anthocyanins, found in both skin and flesh. Here, we present the first bilberry genome assembly, comprising 12 pseudochromosomes assembled using Oxford Nanopore (ONT) and Hi-C Technologies. The pseudochromosomes represent 96.6% complete BUSCO genes with an assessed LAI score of 16.3, showing a high conservation of synteny against the blueberry genome. Kmer analysis showed an unusual third peak, indicating the sequenced samples may have been from two individuals. The alternate alleles were purged so that the final assembly represents only one haplotype. A total of 36,404 genes were annotated after nearly 48% of the assembly was masked to remove repeats. To illustrate the genome quality, we describe the complex MYBA locus, and identify the key regulating MYB genes that determine anthocyanin production. The new bilberry genome builds on the genomic resources and knowledge of Vaccinium species, to help understand the genetics underpinning some of the quality attributes that breeding programs aspire to improve. The high conservation of synteny between bilberry and blueberry genomes means that comparative genome mapping can be applied to transfer knowledge about marker-trait association between these two species, as the loci involved in key characters are orthologous. 相似文献
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Maria E Manetti Magdalena Rossi Ana PP Costa Andrea M Clausen Marie-Anne Van Sluys 《BMC evolutionary biology》2007,7(1):34
Background
Tnt1 was the first active plant retrotransposon identified in tobacco after nitrate reductase gene disruption. The Tnt1 superfamily comprises elements from Nicotiana (Tnt1 and Tto1) and Lycopersicon (Retrolyc1 and Tlc1) species. The study presented here was conducted to characterise Tnt1-related sequences in 20 wild species of Solanum and five cultivars of Solanum tuberosum. 相似文献5.
Temporal and spatial transcriptomic and microRNA dynamics of CAM photosynthesis in pineapple
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CH4 emission from a hollow-ridge complex in a raised bog: The role of CH4 production and oxidation 总被引:5,自引:0,他引:5
The aim of this study was to correlate magnitude andcontrols of CH4 fluxes with the microtopographyand the vegetation in a hollow-ridge complex of araised bog. High CH4 emission rates were measuredfrom hollows and mud-bottom hollows, while hummocksconsumed atmospheric CH4 at a low rate. Thehighest emissions were measured from plots with Eriophorum vaginatum and Scheuchzeriapalustris. CH4 emission ceased after Scheuchzeria had been clipped below the water table,indicating the importance of this aerenchymatic plantas a conduit for CH4.Peat in the upper catotelm of hollows was younger andless decomposed than in hummocks. Potential CH4production in vitro was higher and themethanogenic association was better adapted to highertemperatures in hollow than in hummock peat. Highertemperatures in hollows resulted in a strongerCH4 source in hollows than in hummocks. Negativefluxes from hummocks indicated that even in wetlandsmethanotrophic bacteria exist that are able to oxidizeCH4 at atmospheric mixing ratios, and thatoxidation controls CH4 emission completely. TheCH4 mixing ratio was low in the acrotelm, but itincreased within the catotelm. Comparing fluxesmeasured in static chambers with fluxes calculatedfrom the porewater CH4 profiles it was deducedthat the zone of methane oxidation was located closeto the water table.In hollows, CH4 production at in situtemperature was far higher than emission into theatmosphere, corresponding to an oxidation rate ofnearly 99%. The CH4 flux between the catotelmand the acrotelm of hollows was also higher than theemission, indicating the importance of CH4oxidation in the aerobic acrotelm, too. CH4microprofiles showed that CH4 oxidation inmud-bottom hollows was confined to the topmost 2 mm,and that in Sphagnum-covered hollows CH4oxidation occurred at the lower edge of green Sphagnum-parts. 相似文献
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Won Cheol Yim Mia L Swain Dongna Ma Hong An Kevin A Bird David D Curdie Samuel Wang Hyun Don Ham Agusto Luzuriaga-Neira Jay S Kirkwood Manhoi Hur Juan K Q Solomon Jeffrey F Harper Dylan K Kosma David Alvarez-Ponce John C Cushman Patrick P Edger Annaliese S Mason J Chris Pires Haibao Tang Xingtan Zhang 《The Plant cell》2022,34(11):4143
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Makenzie E. Mabry Julia M. Brose Paul D. Blischak Brittany Sutherland Wade T. Dismukes Christopher A. Bottoms Patrick P. Edger Jacob D. Washburn Hong An Jocelyn C. Hall Michael R. McKain Ihsan Al-Shehbaz Michael S. Barker M. Eric Schranz Gavin C. Conant J. Chris Pires 《American journal of botany》2020,107(8):1148-1164
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