排序方式: 共有7条查询结果,搜索用时 156 毫秒
1
1.
Soheila Moein Mostafa Vaghari-Tabari Durdi Qujeq Maryam Majidinia Seyed Mohammad Nabavi Bahman Yousefi 《Journal of cellular physiology》2019,234(4):3277-3293
Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is caused by a dysregulated and aberrant immune response to exposed environmental factors in genetically susceptible individuals. Despite huge efforts in determining the molecular pathogenesis of IBD, an increasing worldwide incidence of IBD has been reported. MicroRNAs (miRNAs) are a set of noncoding RNA molecules that are about 22 nucleotides long, and these molecules are involved in the regulation of the gene expression. By clarifying the important role of miRNAs in a number of diseases, their role was also considered in IBD; numerous studies have been performed on this topic. In this review, we attempt to summarize a number of studies and discuss some of the recent developments in the roles of miRNAs in the pathophysiology, diagnosis, and treatment of IBD. 相似文献
2.
M. Izadinia M. Nobakht F. Khajali M. Faraji F. Zamani D. Qujeq I. Karimi 《Animal Feed Science and Technology》2010,155(2-4):194-200
As canola meal protein (CMP) has a lower arginine (Arg) content than soybean meal protein (SBMP), the main objective of this study was to investigate if replacing SBMP by CMP affected the incidence of pulmonary hypertension and ascites. Two hundred and seventy broiler chicks (Ross 308) were used to evaluate the effect of replacing CMP at proportionally 0, 0.5, and 1 for SBMP in a complete randomized block design, as mentioned in the Statistical analysis section (dietary treatments designated as CMP0, CMP0.5, and CMP1, respectively). The experiment was carried out on litter flooring from 6 to 42 days of age. The results indicate that broiler performance (body weight gain, feed intake, and feed conversion ratio) was significantly (P<0.05) impaired in the CMP1 group at 6–21 days but not at 21–42 days. Inclusion of canola meal (CM) in the diet significantly increased ascites and total mortality (P<0.05) and caused a decrease in the serum nitric oxide (NO) concentration with a concomitant increase (P<0.05) in the right ventricular weight ratio (RV/TV). Haematocrit, circulatory triiodothyronine and thyroxine thyroid hormone concentrations and serum alkaline phosphatase activity were unaffected by dietary treatments. In conclusion, the results of this study indicate that substitution of CMP for SBMP was associated with pulmonary hypertension (i.e., higher RV/TV) and ascites mortality in broiler chickens. 相似文献
3.
Maryam Abolghasemi Tooba Yousefi Mahmood Maniati Durdi Qujeq 《Journal of cellular biochemistry》2019,120(9):14306-14317
Klotho (KL) gene has been accepted as an "aging suppressor" gene that encodes a single transmembrane protein in human known as Klotho which is commonly expressed in renal tubes. The interruption in the secretion of Klotho protein expedites aging whereas its high expression extends lifespan. The family of Klotho proteins has been reported to act as distinct receptors for endocrine fibroblast growth factors (FGFs), which manage multifarious metabolic processes. Further, the secreted Klotho is a hormonal factor that takes part in the ion channel organization. Numerous studies determined that this protein affects the function of a number of important signaling pathways, which may present an impact in tumorigenesis via the coordination of receptors located on them. This review article focuses on the effects of microRNAs on the performance of Klotho and how the interplay between Klotho and certain pathways like insulin-like growth factor, FGF, Wnt, and transforming growth factor β contribute to the biogenesis of cancer. The present study is also pointed at defining the molecular mechanisms of these interactions. 相似文献
4.
Qujeq D 《Steroids》2002,67(13-14):1071-1077
We investigated the first step of the sex steroid hormone biosynthesis pathway by assaying the activities of 3 beta-hydroxy-delta 5-steroid dehydrogenase, the rate-limiting enzyme in this pathway. We have developed a simple and rapid colorimetric assay for 3 beta-hydroxy-delta 5-steroid dehydrogenase in rat testis. The supernatant from rat testis tissue homogenates were used for the enzyme assay. The enzyme activity was determined by measuring the absorbance at 570nm which indicates the rate of conversion of pregnenolone into progesterone in the presence of NAD, using phenazine methosulfate and nitro blue tetrazolium as the color reagent. The activity of this enzyme ranged from 4.57+/-1.34 to 10.56+/-2.13 nmol/mg protein/min with a mean activity of 8.96+/-1.27 nmol/mg protein/min. The K(m) of the enzyme at an optimum pH of 7.25 was about 4.7+/-0.12 nM. 相似文献
5.
The crosstalk between trace elements with DNA damage response,repair, and oxidative stress in cancer
Sadra Samavarchi Tehrani Hamideh Mahmoodzadeh Hosseini Tooba Yousefi Maryam Abolghasemi Durdi Qujeq Mahmood Maniati Jafar Amani 《Journal of cellular biochemistry》2019,120(2):1080-1105
DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell-cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer. 相似文献
6.
The effect of the glycolipoprotein extract (G‐90) from earthworm Eisenia foetida on the wound healing process in alloxan‐induced diabetic rats
下载免费PDF全文
![点击此处可从《Cell biochemistry and function》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Golnaz Goodarzi Durdi Qujeq Maryam M. Elmi Farideh Feizi Sadegh Fathai 《Cell biochemistry and function》2016,34(4):242-249
Diabetes is now regarded as a major public health problem. The number of patients is estimated to increase to over 439 million cases by 2030. One of the major health clinical problems in patients with diabetes patients is impaired wound healing. Diabetic foot ulcer is a major complication of diabetes mellitus in 12 to 25% of patients, which increases the risk of damage in the limbs or amputation. The earthworm Eisenia foetida glycolipoprotein (as known G‐90) is a blend of macromolecules with some biological properties including mitogenicity, anticoagulation, fibrinolysis, bacteriostatic and antioxidatiaon. Given the biological properties of G‐90, this study was conducted to investigate the effect of extract obtained from the homogenate of Eisenia foetida (G‐90) on the wound healing process in alloxan‐induced diabetic rats. The results of the present study revealed that treatment by using G‐90 can speed up the wound healing process, which is exactly similar to the effect of D‐panthenol treatment in rats. These findings also demonstrated that G‐90 treatment decreases the risk of infection in the wound site compared with D‐panthenol treatment. In addition, histological analysis indicated that a better extracellular matrix formation with increased fibroblast proliferation, neovascularization, collagen synthesis and early epithelial layer formation was observed in G‐90 treated group. Therefore, the G‐90 could be considered as a new wound healing agent introducing promising therapeutic approaches in both human and veterinary medicine. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
7.
Protection of bone marrow,mononuclear, and CD34+ cells by enclosing within the biochemical compound solution during and after transplantation
下载免费PDF全文
![点击此处可从《Cell biochemistry and function》网站下载免费的PDF全文](/ch/ext_images/free.gif)
We have chosen collagen, chitosan acetate, hyaluronic acid, and propolis as model biochemical compound solution to determine the influence of cell carrier mechanics on cell viability and functionality during and after transplantation. Suspending of bone marrow (BM), mononuclear (MN), and CD34+ cells into a biochemical compounds solution is an attractive tool to achieve to protect and ensure reproducible deliver. Hyperglycemic rats were randomly divided into 2 groups: to receive no cell treatment or approximately 1 × 105 of BM, MN, and CD34+ cells within the PBS or biochemical compound solution. These cells were infused into the hyperglycemic rats on day 10 and again on day 20. At each time point, the animals were anaesthetized with ether, and 200 μL of blood was drawn from the tail vein. Samples were collected to determine whether BM, MN, and CD34+ cell affected glucose content and insulin production. Our results exhibit the use of biochemical compound solution method to overcome the cell transplantation problem during and after injection of these cells into rats. These findings are supported by resulting in significantly greater insulin production and more decreased glucose content than cells injected in PBS only (P < 0.05). These effects displayed the following hierarchy: hyaluronic acid > chitosan acetate > collagen > propolis solution. Our results showed that these compounds demonstrated a capacity to encapsulate the BM, MN, and CD34+ cells. It is proven by decreasing glucose content and increasing insulin secretion by pancreatic cells. The uniqueness of our study is the improvement of current transplantation efficiency. 相似文献
1