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Liu Lin Yang Dongfeng Xing Bingcong Zhang Chenlu Liang Zongsuo 《Plant Cell, Tissue and Organ Culture》2020,140(2):459-467
Plant Cell, Tissue and Organ Culture (PCTOC) - Tanshinones are major secondary metabolites in Salvia miltiorrhiza Bunge, the traditional Chinese medicinal plant Danshen. Increasing the production... 相似文献
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− 866G/A polymorphism in the promoter of UCP2 gene has been reported to be associated with obesity, but the results remain inconclusive. To assess the relation of UCP2 − 866G/A polymorphism and obesity susceptibility, a meta-analysis was performed. PubMed, ISI, Wanfang database, VIP and CBM were searched to identify relevant studies up to July 31, 2012. Odds ratios (OR) and 95% confidence interval (95% CI) were pooled using fixed or random effect models. Subgroup analysis was performed by ethnicity (categorized as Asian and European). Heterogeneity and publication bias evaluation were performed to validate the credibility. Meta-regression and the ‘leave one out’ sensitive analysis were used to explore the potential sources of between-study heterogeneity. 14 studies were included in this meta-analysis. After exclusion of articles that deviated from the HWE in controls, and were the key contributors to between-study heterogeneity, the meta-analysis showed a significant association of the A allele with reduced risk of obesity in overall analysis and in European in the dominant, codominant and additional models. In Asian, no significant association was found between the − 866G/A in UCP2 gene and obesity susceptibility. The meta-analysis suggested that UCP2 − 866G/A polymorphism was associated with obesity. The A allele may be an important protective factor for obesity in European, but not in Asian. Further studies are needed to elucidate the relationship. 相似文献
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Hongmei Duan Zengchang Pang Dongfeng Zhang Haiping Duan Jacob v.B. Hjelmborg Qihua Tan Torben A. Kruse Kirsten O. Kyvik 《Obesity (Silver Spring, Md.)》2013,21(9):1908-1914
Objectives : A twin‐based comparative study on the genetic influences in metabolic endophenotypes in two populations of substantial ethnic, environmental, and cultural differences was performed. Design and Methods : Data on 11 metabolic phenotypes including anthropometric measures, blood glucose, and lipids levels as well as blood pressure were available from 756 pairs of Danish twins (309 monozygotic and 447 dizygotic twin pairs) with a mean age of 38 years (range: 18‐67) and from 325 pairs of Chinese twins (183 monozygotic and 142 dizygotic twin pairs) with a mean age of 40.5 years (range: 18‐69). Twin modeling was performed on full and nested models with the best fitting models selected. Results : Heritability estimates were compared between Danish and Chinese samples to identify differential genetic influences on each of the phenotypes. Except for hip circumference, all other body measures exhibited similar heritability patterns in the two samples with body weight showing only a slight difference. Higher genetic influences were estimated for fasting blood glucose level in Chinese twins, whereas the Danish twins showed more genetic regulation over most lipids phenotypes. Systolic blood pressure was more genetically controlled in Danish than in Chinese twins. Conclusions : Metabolic endophenotypes show disparity in their genetic determinants in populations under distinct environmental conditions. 相似文献
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Wang Jun Liu Fangchao Li Jianxin Huang Keyong Yang Xueli Chen Jichun Liu Xiaoqing Cao Jie Chen Shufeng Shen Chong Yu Ling Lu Fanghong Wu Xianping Zhao Liancheng Li Ying Hu Dongsheng Huang Jianfeng Gu Dongfeng Lu Xiangfeng 《中国科学:生命科学英文版》2022,65(1):119-128
Science China Life Sciences - Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease (CVD) and all-cause mortality was inconsistent. These... 相似文献
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Background
Malignant granular cell tumor (MGCT) is a rare disease entity. Forty-one well-documented MGCTs have been reported in the world literature. 相似文献10.
鸟类呼吸与发声的神经调控 总被引:4,自引:2,他引:2
鸟类的发声产生于呼吸过程的呼气相;呼吸与发声中枢控制通路间具有复杂的纤维联系,构成“发声通讯复合体”;前脑的RA是鸣禽协调呼吸与发声的高位中枢;脑干部的DM、nRAm、PBvl、IOS、RVL及Ⅻts等核团参与呼吸肌及鸣肌活动的调节,使呼吸与发声的配合准确、协调。 相似文献