排序方式: 共有15条查询结果,搜索用时 31 毫秒
1.
Severo Juliana Soares Morais Jennifer Beatriz Silva Beserra Jessica Batista dos Santos Loanne Rocha de Sousa Melo Stéfany Rodrigues de Sousa Gustavo Santos de Matos Neto Emídio Marques Henriques Gilberto Simeone do Nascimento Marreiro Dilina 《Biological trace element research》2020,193(1):81-88
Biological Trace Element Research - Excessive adipose tissue promotes the manifestation of endocrine disorders such as reduction of the secretion of zinc-α2-glycoprotein (ZAG), an adipokine... 相似文献
2.
Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents 总被引:4,自引:0,他引:4
A perturbation of zinc metabolism has been noted in subjects with obesity. The present work intends to investigate whether
the zinc nutritional status is associated with hyperinsulinemia in obesity. A study was carried out in a group of obese children
and adolescents (n=23) and compared to a control group (n=21), both between 7 and 14 yr of age. Software analyzed diet information from 3-d food records. Body composition was evaluated
by body mass index (BMI), bioelectrical impedance, and skinfold measurements. Zinc nutritional status was evaluated by Zn
determination in plasma, erythrocyte, and 24-h urine, by atomic absorption spectrophotometry (λ=213.9 nm). Insulin was measured
by radioimmunoassay (Linco Res). Diets consumed by both groups had marginal concentrations of zinc. Zinc concentrations in
plasma and erythrocytes were significantly lower in the obese group. Urinary zinc excretion and serum insulin were significantly
higher in the same group, although the insulinemia and the parameters of zinc nutritional status were not significantly correlated.
As a result, considering that zinc is part of the synthesis and secretion of this hormone, an assessment is necessary of the
possible participation of the oligoelement in the mechanisms of insulin resistance, commonly present in obese patients. 相似文献
3.
Marreiro DN do Perpetuo Socorro C Martins M de Sousa SS Ibiapina V Torres S Pires LV do Nascimento Nogueira N Lima JM do Monte SJ 《Biological trace element research》2007,120(1-3):42-50
The objective of this study was to assess urinary excretion of zinc and evaluation parameters of metabolic control in type
2 diabetic patients. Thirty-one type 2 diabetic patients, of both genders, with 5.8 ± 5.6 years average time of the disease,
age range 20–60 years, were selected. Evaluation of the nutritional status was performed using anthropometric measurements.
To evaluate food consumption, the 3-day alimentary log method was used, and its analysis was performed using a software. Determination
of urinary zinc was by atomic absorption spectrophotometry. From the obtained results, it was concluded that 51.6% of the
patients were overweight. The mean of found waist circumference was 100.4 and 92.2 cm for men and women, respectively. Blood
glucose and glycated hemoglobin values were higher than reference values, and plasma albumin concentration was adequate. The
median of found urinary zinc excretion was 474.9 μg/24 h, within normal standards (300–600 μg/day). Regarding diet composition,
calorie and protein concentration were above recommendation, while mean zinc concentration was adequate. This data allow the
conclusion that the evaluated patients presented adequate urinary zinc excretion in comparison with reference values. 相似文献
4.
Ferro FE de Sousa Lima VB Soares NR de Sousa Almondes KG Pires LV Cozzolino SM do Nascimento Marreiro D 《Biological trace element research》2011,143(2):787-793
Alterations in antioxidant defense in obese people with metabolic syndrome can contribute to oxidative stress. This study
assessed the relationship between the parameters of metabolic syndrome and the zincemia, activity of superoxide dismutase,
and glutathione peroxidase enzymes in obese women. Seventy-three premenopausal women, aged between 20 and 50 years, were divided
into two groups: case group, composed of obese (n = 37), and control group, composed of no obese (n = 36). Analyses of zinc intake, parameters of metabolic syndrome, plasma, and erythrocyte zinc, and activities of superoxide
dismutase and glutathione peroxidase were carried out. The mean values of body mass index of obese women and control group
were 34.5 ± 3.4 and 21.7 ± 1.9 kg/m2, respectively (p < 0.05). In the study, body mass index, waist circumference, and zinc intake were higher in obese women than control group
(p < 0.05). The plasma zinc and activity of superoxide dismutase did not show significant differences between obese and controls
(p > 0.05). The values of erythrocyte zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb and of glutathione peroxidase was 46.4 ± 19.4 U/gHb
and 36.7 ± 13.6 U/gHb in obese women and controls, respectively (p < 0.05). The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations
in erythrocytes. Regression analysis demonstrates that the erythrocyte zinc and activity of superoxide dismutase enzyme is
influenced by components of the metabolic syndrome, and the plasmatic glucose, body mass index, and waist circumference have
a negative correlation with this enzyme. 相似文献
5.
Dilina do Nascimento Marreiro Artemizia Francisca de Sousa Nadir do Nascimento Nogueira Francisco Erasmo Oliveira 《Biological trace element research》2009,129(1-3):20-27
Studies have evidenced that zinc metabolism is altered in the presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the effect of zinc supplementation on thyroid hormone metabolism was evaluated in adolescents with Down syndrome. A prospective study was carried out on 16 adolescents with Down syndrome (age: 10–19 years) who were randomized for treatment with 30 mg zinc daily for 4 weeks. Diet evaluation was accomplished y using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Anthropometric measurements were performed for evaluation of body composition. The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes using the method of atomic absorption spectroscopy, and the thyroid hormone was obtained by radioimmunoassay. The diet of patients with Down syndrome, before and after the intervention presented reduced energy level and adequate zinc concentrations. Mean plasma zinc values were 59.2?±?13.2 and 71.0?±?21.9 μg/dL before and after the intervention, respectively. Erythrocyte concentrations of the mineral before supplementation, instead, were 51.5 μg/dL?±?11.1 μg Zn/gHb, and at the end of the experiment, they were 42.9?±?8/5 μg Zn/gHb, with a significant statistical difference (p?<?0.05). Serum concentrations of T4 hormone before and after zinc supplementation were 1.26?±?0.20 and 1.54?±?0.63 pg/mL, respectively. Mean T3 values before intervention were 2.47?±?037 pg/mL and, after supplementation, 2.25?±?0.67 pg/mL, without significant statistical difference (p?>?0.05). Intervention with zinc showed to be effective in the stabilization of the concentrations of this mineral in plasma and erythrocytes, but had no influence on the metabolism of thyroid hormones. 相似文献
6.
da Costa GA do Nascimento Marreiro D Eulálio JM Neto JM Amorim AC Nogueira AM do Monte SJ Nogueira Ndo N 《Biological trace element research》2008,126(Z1):S15-S20
This study evaluated nutritional status linked to zinc levels in 239 randomly selected children at crèches in Teresina, Brazil, aged 3 to 6. Blood samples were collected after fasting of 10 h. Erythrocytary zinc levels were determined through flame atomic absorption spectrophotometry. Zinc deficiency was determined as below 40 microg Zn/g Hb. Infant linear growth was evaluated measuring weight and height, and nutritional status by height/age, weight/height, and weight/age indices, expressed as Z scores, in line with the National Center for Health Statistics. The mean zinc concentration was 35.50 +/- 10.95 microg Zn/g Hb. Zinc distribution in the 10, 50, 75, and 90 percentiles was 24.73 microg Zn/g Hb, 35.45 microg Zn/g Hb, 40.73 microg Zn/g Hb and 52.77 microg Zn/g Hb, respectively. Based on this distribution, normal values were found only from the 75th percentile and above. Since the cutoff point adopted was 40 microg Zn/g Hb, the prevalence of zinc deficiency was 74.3%. As for growth profile, 8.4% were chronically malnourished, although the statistical association between linear impairment and nutritional status regarding zinc was insignificant. The study revealed that an important segment of the infant population was mineral deficient; however, the degree of deficiency did not influence growth profiles. 相似文献
7.
Marreiro DN Geloneze B Tambascia MA Lerário AC Halpern A Cozzolino SM 《Biological trace element research》2006,112(2):109-118
Leptin is thought to be a lipostatic signal that contributes to body weight regulation. Zinc might play an important role in appetite regulation and its administration stimulates leptin production. However, there are few reports in the literature on its role on leptin levels in the obese population. The present work assesses the effect of zinc supplementation on serum leptin levels in insulin resistance (IR). A prospective double-blind, randomized, clinical, placebo-controlled study was conducted. Fifty-six normal glucose-tolerant obese women (age: 25-45 yr, body mass index [BMI] = 36.2 +/- 2.3 kg/m2) were randomized for treatment with 30 mg zinc daily for 4 wk. Baseline values of both groups were similar for age, BMI, caloric intake, insulin concentration, insulin resistance, and zinc concentration in diet, plasma, urine, and erythrocytes. Insulin and leptin were measured by radioimmunoassay and IR was estimated by the homeostasis model assessment (HOMA). The determinations of zinc in plasma, erythrocytes, and 24- h urine were performed by using atomic absorption spectrophotometry. After 4 wk, BMI, fasting glucose, and zinc concentration in plasma and erythrocyte did not change in either group, although zinc concentration in the urine increased from 385.9 +/- 259.3 to 470.2 +/- 241.2 +/- microg/24 h in the group with zinc supplementation (p < 0.05). Insulin did not change in the placebo group, whereas there was a significant decrease of this hormone in the supplemented group. HOMA also decreased from 5.8 +/- 2.6 to 4.3 +/- 1.7 (p < 0.05) in the zinc-supplemented group but did not change in the placebo group. Leptin did not change in the placebo group. In the zinc group, leptin was 23.6 +/- 12.3 microg/L and did not change. More human data from a unique population of obese individuals with documented insulin resistance would be useful in guiding future studies on zinc supplementation (with higher doses or longer intervals) or different measures. 相似文献
8.
Kyria Jayanne Clímaco Cruz Ana Raquel Soares de Oliveira Denise Pereira Pinto Jennifer Beatriz Silva Morais Fabiana da Silva Lima Célia Colli Francisco Leonardo Torres-Leal Dilina do Nascimento Marreiro 《Biological trace element research》2014,160(3):305-310
The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n?=?59) and case (obese women, n?=?55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. The determinations of serum glucose and serum insulin were performed by enzymatic colorimetric method and chemiluminescence, respectively. The insulin resistance was assessed by homeostasis model assessment insulin resistance (HOMA-IR). The mean values of magnesium intake were lower than those recommended, without difference between groups (p?>?0.05). All the patients who were evaluated showed adequate mean concentrations of magnesium in the plasma and erythrocyte. The urinary excretion of this mineral was lower than the reference values in both groups and did not show significant difference (p?>?0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women compared to the control group. A negative correlation was observed between erythrocyte magnesium and glycemic parameters (p?0.05). Obese patients take in foods with low dietary magnesium content, and they show hypomagnesuria as a compensatory mechanism to keep the plasma concentration of this mineral in adequate levels. The correlation between the erythrocyte magnesium concentration and the parameters of glycemic control suggests the influence of this mineral on the index of insulin resistance in obese women. 相似文献
9.
10.
Marques RC de Sousa AF do Monte SJ Oliveira FE do Nascimento Nogueira N Marreiro DN 《Biological trace element research》2007,120(1-3):11-18
Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship
with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents
with Down syndrome was evaluated by means of biochemical parameters and diet. A case–control study was performed in a group
of adolescents with Down syndrome (n = 30) and a control group (n = 32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis
was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition.
The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and
erythrocytes, and 24-h urinary zinc excretion, by using the method of atomic absorption spectroscopy. The diet of both groups
presented adequate concentrations of lipids, proteins, carbohydrates, and zinc. The mean values found for zinc concentration
in erythrocytes were 49.2 ± 8.5 μg Zn/g Hb for the Down syndrome group and 35.9 ± 6.1 μg Zn/g Hb for the control group (p = 0.001). The average values found for zinc concentration in plasma were 67.6 ± 25.6 μg/dL for the Down syndrome group and
68.9 ± 22.3 μg/dL for the control group. The mean values found for zinc concentration in urine were 244.3 ± 194.9 μg Zn/24 h
for the Down syndrome group and 200.3 ± 236.4 μg Zn/24 h for the control group. Assessment of body composition revealed overweight
(26.7%) and obesity (6.6%) in the Down syndrome group. In this study, patients with Down syndrome presented altered zinc levels
for some cellular compartments, and the average zinc concentrations were low in plasma and urine and elevated in erythrocytes. 相似文献