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Peter B. Sampson Christine Picard Sean Handerson Teresa E. McGrath Megan Domagala Andrew Leeson Vladimir Romanov Donald E. Awrey Dhushy Thambipillai Elias Bardouniotis Nachum Kaplan Judd M. Berman Henry W. Pauls 《Bioorganic & medicinal chemistry letters》2009,19(18):5355-5358
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet described. The structural model of 14a bound to E. coli FabI is shown. 相似文献
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