排序方式: 共有13条查询结果,搜索用时 15 毫秒
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Mohanan Manoj Vadakkenchery Pushpanathan Anunanthini Padmanabhan Sarath Sasikumar Thelakat Jayanarayanan Ashwin Narayan Selvarajan Dharshini Ramalingam Sathishkumar Ram Bakshi Chinnaswamy Appunu 《Journal of plant research》2021,134(5):1083-1094
Journal of Plant Research - The glyoxalase pathway is a check point to monitor the elevation of methylglyoxal (MG) level in plants and is mediated by glyoxalase I (Gly I) and glyoxalase II (Gly II)... 相似文献
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Ishvaria S. Dharshini Rajathirajan Siva Manickam Ranjani Pooja K. R. Ramya Mohandass 《Antonie van Leeuwenhoek》2021,114(12):1977-1989
Antonie van Leeuwenhoek - Biofilm forming bacterium Bacillus novalis PD1 was isolated from the rhizospheric soil of a paddy field. B. novalis PD1 is a Gram-positive, facultatively anaerobic,... 相似文献
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Su X Lawrence H Ganeshapillai D Cruttenden A Purohit A Reed MJ Vicker N Potter BV 《Bioorganic & medicinal chemistry》2004,12(16):4439-4457
Extensive structural modifications to the 18beta-glycyrrhetinic acid template are described and their effects on the SAR of the 11beta-hydroxysteroid dehydrogenase isozymes type 1 and 2 from the rat are investigated. Isoform selective inhibitors have been discovered and compound 7 N-(2-hydroxyethyl)-3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic acid amide is highlighted as a very potent selective inhibitor of 11beta-hydroxysteroid dehydrogenase 2 with an IC(50) = 4pM. 相似文献
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Dharshini Rajathirajan Siva Manickam Ranjani Curtis Wayne R. Rathinasabapathi Pasupathi Ramya Mohandass 《Antonie van Leeuwenhoek》2021,114(12):2205-2217
Antonie van Leeuwenhoek - Pseudomonas aeruginosa strain SW1 is an aerobic, motile, Gram-negative, and rod-shaped bacterium isolated from degraded seaweeds. Based on the 16S rRNA gene sequence and... 相似文献
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Dharshini Gopal Aditi G Muddebihalkar Akshay Uttarkar C Prinith Kaveramma Ulluvangada Praveen 《Journal of biomolecular structure & dynamics》2020,38(15):4584-4599
AbstractCandida albicans, fungal yeast causes several lethal infections in immune-suppressed patients and recently emerged as drug-resistant pathogens worldwide. The present study aimed to screen putative drug targets of Candia albicans and to study the binding potential of novel natural lead compounds towards these targets by computational virtual screening and molecular dynamic (MD) simulation. Through extensive analysis of mitogen-activated protein kinase (MAPK) signalling pathways, mitogen-activated protein kinase-1 (HOG1) and cell division control protein-42 (CDC42) genes were prioritized as putative targets based on their virulent functions. The three-dimensional structures of these genes, not available in their native forms, were computationally modeled and validated. 76 lead molecules from various natural sources were screened and their drug likeliness and pharmacokinetic features were predicted. Among these ligands, two lead molecules that demonstrated ideal drug-likeliness and pharmacokinetic features were docked against HOG1 and CDC42 and their binding potential was compared with the binding of conventional drug Fluconazole with their usual target. The prediction was computationally validated by MD simulation. The current study revealed that Cudraxanthone-S present in Cudrania cochinchinensis and Scutifoliamide-B present in Piper scutifolium exhibited ideal drug likeliness, pharmacokinetics and binding potential to the prioritized targets in comparison with the binding of Fluconazole and their usual target. MD simulation showed that CDC42-Cudraxanthone-S and HOG1-Scutifoliamide-B complexes were exhibited stability throughout MD simulation. Thus, the study provides significant insight into employing HOG1 and CDC42 of MAPK as putative drug targets of C. albicans and Cudraxanthone-S and Scutifoliamide-B as potential inhibitors for drug discovery.Communicated by Ramaswamy H. Sarma 相似文献
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Ramasamy R Surendran SN Jude PJ Dharshini S Vinobaba M 《PLoS neglected tropical diseases》2011,5(11):e1369
Aedes aegypti (Linnaeus) and Aedes albopictus Skuse mosquitoes transmit serious human arboviral diseases including yellow fever, dengue and chikungunya in many tropical and sub-tropical countries. Females of the two species have adapted to undergo preimaginal development in natural or artificial collections of freshwater near human habitations and feed on human blood. While there is an effective vaccine against yellow fever, the control of dengue and chikungunya is mainly dependent on reducing freshwater preimaginal development habitats of the two vectors. We show here that Ae. aegypti and Ae. albopictus lay eggs and their larvae survive to emerge as adults in brackish water (water with <0.5 ppt or parts per thousand, 0.5-30 ppt and >30 ppt salt are termed fresh, brackish and saline respectively). Brackish water with salinity of 2 to 15 ppt in discarded plastic and glass containers, abandoned fishing boats and unused wells in coastal peri-urban environment were found to contain Ae. aegypti and Ae. albopictus larvae. Relatively high incidence of dengue in Jaffna city, Sri Lanka was observed in the vicinity of brackish water habitats containing Ae. aegypti larvae. These observations raise the possibility that brackish water-adapted Ae. aegypti and Ae. albopictus may play a hitherto unrecognized role in transmitting dengue, chikungunya and yellow fever in coastal urban areas. National and international health authorities therefore need to take the findings into consideration and extend their vector control efforts, which are presently focused on urban freshwater habitats, to include brackish water larval development habitats. 相似文献
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Douglas SA Sreenivasan D Carman FH Bunn SJ 《Cellular and molecular neurobiology》2010,30(8):1467-1475
It is generally accepted that a bi-directional or reciprocal interaction occurs between the immune and neuroendocrine systems,
and that this relationship is important for the appropriate physiological functioning of both systems. Similarly, an imbalance
in this relationship may contribute to a number of pathologies, most notably those relating to stress. The aim of this article
is to consider the interaction of cytokines with the adrenal medulla, a potentially important player in this relationship.
The chromaffin cells of the adrenal medulla release catecholamines and a range of biologically active peptides in response
to a wide variety of stress-related signals. A growing body of evidence indicates that this stress response is influenced
by, and in turn has influence upon, immune signalling. This brief review will focus primarily on the best-described adrenal
medullary active cytokines, namely interferon-α, interleukin-6, interleukin-1α/β and tumour necrosis factor-α. In each case,
three key issues will be addressed: the physiologically relevant source of the cytokine; the intracellular signalling events
arising from activation of its receptor and finally the cellular consequences of such activation in terms of modulation of
gene expression and the secretory output of the chromaffin cells. 相似文献
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Jeevarajah D Patterson JH Taig E Sargeant T McConville MJ Billman-Jacobe H 《Journal of bacteriology》2004,186(20):6792-6799
Several species of mycobacteria express abundant glycopeptidolipids (GPLs) on the surfaces of their cells. The GPLs are glycolipids that contain modified sugars including acetylated 6-deoxy-talose and methylated rhamnose. Four methyltransferases have been implicated in the synthesis of the GPLs of Mycobacterium smegmatis and Mycobacterium avium. A rhamnosyl 3-O-methytransferase and a fatty acid methyltransferase of M. smegmatis have been previously characterized. In this paper, we characterize the methyltransferases that are responsible for modifying the hydroxyl groups at positions 2 and 4 of rhamnose and propose the biosynthetic sequence of GPL trimethylrhamnose formation. The analysis of M. avium genes through the creation of specific mutants is technically difficult; therefore, an alternative approach to determine the function of putative methyltransferases of M. avium was undertaken. Complementation of M. smegmatis methyltransferase mutants with M. avium genes revealed that MtfC and MtfB of the latter species have 4-O-methyltransferase activity and that MtfD is a 3-O-methyltransferase which can modify rhamnose of GPLs in M. smegmatis. 相似文献