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排序方式: 共有95条查询结果,搜索用时 500 毫秒
1.
M Dhananjaya Naidu K Ravindran K S Swami 《Archives internationales de physiologie et de biochimie》1988,96(2):75-79
Male albino rats were treated with insulin for one week (acute) and four weeks (chronic). The lactate dehydrogenase (LDH) activity, lactate and pyruvate levels were estimated in the tissues of experimental and control animals. LDH activity decreased in all the tissues of acute- and chronic treated animals whereas the lactate content is elevated. Pyruvate content also showed increment except in heart and pancreas with reference to acute treatment where it is decreased. The hyperinsulinaemia effect in relation to lacticacidaemia and its influence on energy demand and ammonia secretion is discussed. 相似文献
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Singh Dhananjaya P. Tyagi M.B. Kumar Arvind Thakur J.K. Kumar Ashok 《World journal of microbiology & biotechnology》2001,17(1):15-22
Antimicrobial activity of toxin produced by a freshwater bloom-forming cyanobacterium Microcystis aeruginosa has been studied. When tested against certain green algae, cyanobacteria, heterotrophic bacteria and fungi, the toxin inhibited growth of only green algae and cyanobacteria. The toxin has been partially purified employing Thin layer chromatography (TLC) and High-performance liquid chromatography (HPLC) techniques and appears to be microcystin-LR (leucine–arginine). Both crude and purified toxins showed toxicity to mice, the clinical symptoms in test mice being similar to those produced by hepatotoxin. Purified toxin at a concentration of 50 g ml–1 caused complete inhibition of growth followed by cell lysis in Nostoc muscorum and Anabaena BT1 after 6 days of toxin addition. Addition of toxin (25 g ml–1) to the culture suspensions of the Nostoc and Anabaena strains caused instant and drastic loss of O2 evolution. Furthermore a marked reduction (about 87%) in the 14CO2 uptake was also observed at a concentration of 50 g ml–1. Besides its inhibitory effects on photosynthetic processes, M. aeruginosa toxin (50 g ml–1) also caused 90% loss of nitrogenase activity after 8 h of its addition. Experiments performed with 14C-labelled toxin indicate that the toxin uptake by cyanobacterial cells occurs both in light and dark. These results demonstrate that the toxin is strongly algicidal and point to the possibility that it may have an important role in establishment and maintenance of toxic blooms of M. aeruginosa in freshwater ecosystems. The relative significance of the hepatotoxic effect and the algicidal effect of the toxin is discussed with reference both to survival and dominance of M. aeruginosa in nature. 相似文献
4.
Kim DW Chung HK Park KC Hwang JH Jo YS Chung J Kalvakolanu DV Resta N Shong M 《Molecular endocrinology (Baltimore, Md.)》2007,21(12):3039-3049
5.
Meng Q Raha A Roy S Hu J Kalvakolanu DV 《Journal of immunology (Baltimore, Md. : 1950)》2005,174(10):6203-6211
6.
Gowda CD Nataraju A Rajesh R Dhananjaya BL Sharath BK Vishwanath BS 《Comparative biochemistry and physiology. Toxicology & pharmacology : CBP》2006,143(3):295-302
The action of venom proteases and their role in hemostasis has been compared in the venoms of Trimeresurus malabaricus, Daboia russellii and Naja naja from the Southern region of Western Ghats, India. These venoms exhibit varying amounts of proteolytic activity and also influence hemostasis differently. Casein hydrolyzing activity of T. malabaricus venoms was 16 and 24 fold higher than those of N. naja and D. russellii venoms, respectively. With the synthetic substrate TAME, the highest activity was observed in T. malabaricus venom. N. naja venom did not hydrolyze TAME even at higher concentrations. These variations in proteolytic activity also influenced the coagulation process. T. malabaricus and D. russellii venoms are strongly procoagulant and reduce the re-calcification time from 148 to 14 and 12 s, respectively. Similarly, both T. malabaricus and D. russellii venoms reduce the prothrombin time from 12.5 to 6.0 s. On the other hand, N. naja venom is anticoagulant and prolongs re-calcification time to 600 s and prothrombin time to 42 s. In spite of varied effects on hemostasis, all the venoms hydrolyze fibrinogen. T. malabaricus venom hydrolyses both Aalpha and Bbeta subunits. While D. russellii and N. naja venoms hydrolyse only Aalpha. None of these venoms hydrolyze the gamma subunit of fibrinogen. Inhibition studies with specific protease inhibitors revealed that both N. naja and T. malabaricus venoms contain only metalloproteases. D. russellii venom contained both serine and metalloproteases. Only, T. malabaricus venom exhibited thrombin-like activity and induces fibrin clot formation with purified fibrinogen within 58 s. Even though D. russellii venom exhibits procoagulant activity, it did not show thrombin-like activity and may act on other coagulation factors. 相似文献
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Chemical investigation of Mycale mytilorum and a study on toxicity and antidiabetic activity of 5-octadecylpyrrole-2-carboxaldehyde 总被引:1,自引:0,他引:1
Chemical investigation of Mycale mytilorum afforded four new and two known compounds, of which 5-octadecylpyrrole-2-carboxaldehyde (1) and (6'Z)-5-(6'-heneicosenyl) pyrrole-2-carboxaldehyde (2, congeners of alkylpyrrole carboxadehyde), (2S,3R,4E)-1,3-dihydroxy-2-[(heneicosanoyl) amino]-4-heneicosene (5, sphingolipid) and 2-methyl-3-(4,5,7-trihydroxy-8-hydroxy-methyltetrahydro-6H-4-py ranyl)-2-propenoic acid (6, tetrahydropyran derivative) are new, and batylalcohol (3) and p-hydroxyphenylacetic acid (4) are known. The toxicity and antidiabetic activity of 5-octadecylpyrrole-2-carboxaldehyde were evaluated for the first time. Also, compounds 1, 2, 5 and 6 were studied for the antibacterial, antifungal and antiviral activity. 相似文献
9.
A Khamsiriwatchara P Sudathip S Sawang S Vijakadge T Potithavoranan A Sangvichean W Satimai C Delacollette P Singhasivanon S Lawpoolsri J Kaewkungwal 《Malaria journal》2012,11(1):247
ABSTRACT: BACKGROUND: The Bureau of Vector-borne Diseases, Ministry of Public Health, Thailand, has implemented an electronic Malaria Information System (eMIS) as part of a strategy to contain artemisinin resistance. The attempt corresponds to the WHO initiative, funded by the Bill & Melinda Gates Foundation, to contain anti-malarial drug resistance in Southeast Asia. The main objective of this study was to demonstrate the eMIS' functionality and outputs after implementation for use in the Thailand artemisinin-resistance containment project. METHODS: The eMIS had been functioning since 2009 in seven Thai-Cambodian border provinces. The eMIS has covered 61 malaria posts/clinics, 27 Vector-borne Disease Units covering 12,508 hamlets at risk of malaria infections. The eMIS was designed as an evidence-based and near real-time system to capture data for early case detection, intensive case investigation, monitoring drug compliance and on/off-site tracking of malarial patients, as well as collecting data indicating potential drug resistance among patients. Data captured by the eMIS in 2008-2011 were extracted and presented. RESULTS: The core functionalities of the eMIS have been utilized by malaria staff at all levels, from local operational units to ministerial management. The eMIS case detection module suggested decreasing trends during 2009-2011; the number of malaria cases detected in the project areas over the years studied were 3818, 2695, and 2566, with sero-positive rates of 1.24, 0.98, and 1.16%, respectively. The eMIS case investigation module revealed different trends in weekly Plasmodium falciparum case numbers, when classified by responsible operational unit, local and migrant status, and case-detection type. It was shown that most Thai patients were infected within their own residential district, while migrants were infected either at their working village or from across the border. The data mapped in the system suggested that P. falciparum-infected cases and potential drug-resistant cases were scattered mostly along the border villages. The mobile technology application has detected different follow-up rates, with particularly low rates among seasonal and cross-border migrants. CONCLUSION: The eMIS demonstrated that it could capture essential data from individual malaria cases at local operational units, while effectively being used for situation and trend analysis at upper-management levels. The system provides evidence-based information that could contribute to the control and containment of resistant parasites. Currently, the eMIS is expanding beyond the Thai-Cambodian project areas to the provinces that lie along the Thai-Myanmar border. 相似文献
10.
Watcharapong Piyaphanee Chatporn Kittitrakul Saranath Lawpoolsri Philippe Gautret Wataru Kashino Waraluk Tangkanakul Prangthip Charoenpong Thitiya Ponam Suda Sibunruang Weerapong Phumratanaprapin Terapong Tantawichien 《PLoS neglected tropical diseases》2012,6(9)