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Natália F. Haddad Anderson J. Teodoro Felipe Leite de Oliveira Nathália Soares R?mulo Medina de Mattos Fábio Hecht R?mulo Sperduto Dezonne Leandro Vairo Regina Coeli dos Santos Goldenberg Flávia Carvalho Alcantara Gomes Denise Pires de Carvalho M?nica R. Gadelha Luiz Eurico Nasciutti Leandro Miranda-Alves 《PloS one》2016,11(2)
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Carballo Gabriela Basile Ribeiro Jessica Honorato Lopes Giselle Pinto de Faria Ferrer Valéria Pereira Dezonne Romulo Sperduto Pereira Cláudia Maria Spohr Tania Cristina Leite de Sampaio e 《Cellular and molecular neurobiology》2021,41(6):1227-1244
Cellular and Molecular Neurobiology - Glioblastoma (GBM) is the most common adult primary tumor of the CNS characterized by rapid growth and diffuse invasiveness into the brain parenchyma. The GBM... 相似文献
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Lysophosphatidic acid (LPA) plays important roles in many biological processes, such as brain development, oncogenesis and immune functions, via its specific receptors. We previously demonstrated that LPA-primed astrocytes induce neuronal commitment of cerebral cortical progenitors (Spohr et al. 2008). In the present study, we analyzed neurite outgrowth induced by LPA-treated astrocytes and the molecular mechanism underlying this event. LPA-primed astrocytes increase neuronal differentiation, arborization and neurite outgrowth of developing cortical neurons. Treatment of astrocytes with epidermal growth factor (EGF) ligands yielded similar results, suggesting that members of the EGF family might mediate LPA-induced neuritogenesis. Furthermore, treatment of astrocytes with LPA or EGF ligands led to an increase in the levels of the extracellular matrix molecule, laminin (LN), thus enhancing astrocyte permissiveness to neurite outgrowth. This event was reversed by pharmacological inhibitors of the MAPK signaling pathway and of the EGF receptor. Our data reveal an important role of astrocytes and EGF receptor ligands pathway as mediators of bioactive lipids action in brain development, and implicate the LN and MAPK pathway in this process. 相似文献
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