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Al Dera Hussain Alassiri Mohammed Eleawa Samy M. AlKhateeb Mahmoud A. Hussein Abdelaziz M. Dallak Mohammad Sakr Hussein F. Alqahtani Sultan Khalil Mohammad A. 《Neurochemical research》2019,44(8):1851-1868
Neurochemical Research - This study investigated the expression pattern, regulation of expression, and the role of hippocampal small-conductance Ca2+-activated K+ (SK) channels in memory deficits... 相似文献
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Fahaid H. Al-Hashem Mohammad A. Dallak Luke O. Nwoye Ismaeel M. Bin-Jaliah Hasan S. Al-Amri Mahmoud H. Rezk Hussein F. Sakr Abdullah S. Shatoor Mahmoud Al-Khateeb 《Saudi Journal of Biological Sciences》2012,19(1):93-101
Khat chewing is a recreational habit known to pose major socio-economic and medical problems in countries of Southern Arabia and the Horn of Africa. Among other adverse health effects, khat chewing has been associated with an increased risk of myocardial infarction (MI) in heavy consumers. This study was carried out to examine the direct effects of Catha edulis extract on contractility of spontaneously contracting, isolated rabbit heart and to investigate its mechanism of action. Isolated six rabbit’s hearts attached to a Langendorff apparatus were perfused with extract at a constant flow rate and continuously bubbled with a 95% O2/5% CO2 gas mixture. Each heart served as its own control, as responses were recorded before and after administration of C. edulis extract. Varying concentrations of extract (50, 100 and 250 mg/ml) were loaded in the perfusate, their effects recorded and effluent fluid collected for assay of cardiac enzymes. Histological examination of the cardiac tissue was performed at the end of perfusion with 250 mg/ml extract. This study revealed that acute exposure to C. edulis extract exerted negative inotropic and chronotropic effects on isolated hearts. The extract also had a vasoconstrictor effect on coronary vessels, independent of α1 adrenergic receptor stimulation. Histological examination of hearts perfused with 250 mg/ml C. edulis extract revealed the presence of histological changes unique to myocardial infarction, a finding consistent with observed increased levels of cardiac enzymes in perfusates. Thus, we have demonstrated experimentally a direct cardiac depressant- and MI inducing effects of C. edulis extract. These results are consistent with the earlier reported deleterious effects of khat on cardiovascular function among khat chewers. 相似文献
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