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排序方式: 共有153条查询结果,搜索用时 31 毫秒
1.
Mandana Nikpour Dafna D Gladman Dominique Ibanez Paula J Harvey Murray B Urowitz 《Arthritis research & therapy》2010,12(3):R125
Introduction
Total cholesterol (TC) and blood pressure (BP) are likely to take a dynamic course over time in patients with systemic lupus erythematosus (SLE). This would have important implications in terms of using single-point-in-time measurements of these variables to assess coronary artery disease (CAD) risk. The objective of this study was to describe and quantify variability over time of TC and BP among patients with SLE and to determine their correlates. 相似文献2.
Nataly Mancette Rijensky Netta R. Blondheim Shraga Eilon Barnea Nir Peled Eli Rosenbaum Aron Popovtzer Solomon M. Stemmer Alejandro Livoff Mark Shlapobersky Neta Moskovits Dafna Perry Eitan Rubin Itzhak Haviv Arie Admon 《Molecular & cellular proteomics : MCP》2020,19(8):1360-1374
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- •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
- •Using patient derived xenograft (PDX) tumors can overcome this limitation.
- •The large PDX HLA peptidomes expand significantly those of the original biopsies.
- •The HLA peptidomes of the PDX tumors included many tumor antigens.
3.
Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion 总被引:5,自引:0,他引:5
Reuben Lotan Paula N. Belloni Robert J. Tressler Dafna Lotan Xiao-Chun Xu Garth L. Nicolson 《Glycoconjugate journal》1994,11(5):462-468
Lactoside-binding lectins (galectins) with molecular weights of about 14.5 kDa (galectin-1) and 29–35 kDa (galectin-3) bind preferentially to polylactosaminoglycan-containing glycoconjugates and have been found on the surface of tumour cells and implicated in cell-cell and cell-extracellular matrix adhesion and metastasis. We have demonstrated by immunoblotting that both galectin-1 and galectin-3 are present in extracts of endothelial cells cultured from bovine aorta, rat lung, mouse lung and mouse brain microvessels, whereas mouse hepatic sinusoidal endothelial cells expressed primarily galectin-1. These galectins were also localized by indirect immunofluorescent labelling on the surface of the different endothelial cells in culture and by immunohistochemical staining in human tissuesin vivo. Anti-galectin-1 antibodies inhibited the adhesion of liver-preferring murine RAW117-H10 large-cell lymphoma cells to hepatic sinusoidal endothelial cells or lung microvessel endothelial cellsin vitro. The data indicate that galectin-1 is expressed on the extracellular surface of endothelial cells and can mediate in part the adhesion of RAW117-H10 cells to liver microvessel endothelial cells. 相似文献
4.
Objective
Although awareness of sleep disorders is increasing, limited information is available on whole night detection of snoring. Our study aimed to develop and validate a robust, high performance, and sensitive whole-night snore detector based on non-contact technology.Design
Sounds during polysomnography (PSG) were recorded using a directional condenser microphone placed 1 m above the bed. An AdaBoost classifier was trained and validated on manually labeled snoring and non-snoring acoustic events.Patients
Sixty-seven subjects (age 52.5±13.5 years, BMI 30.8±4.7 kg/m2, m/f 40/27) referred for PSG for obstructive sleep apnea diagnoses were prospectively and consecutively recruited. Twenty-five subjects were used for the design study; the validation study was blindly performed on the remaining forty-two subjects.Measurements and Results
To train the proposed sound detector, >76,600 acoustic episodes collected in the design study were manually classified by three scorers into snore and non-snore episodes (e.g., bedding noise, coughing, environmental). A feature selection process was applied to select the most discriminative features extracted from time and spectral domains. The average snore/non-snore detection rate (accuracy) for the design group was 98.4% based on a ten-fold cross-validation technique. When tested on the validation group, the average detection rate was 98.2% with sensitivity of 98.0% (snore as a snore) and specificity of 98.3% (noise as noise).Conclusions
Audio-based features extracted from time and spectral domains can accurately discriminate between snore and non-snore acoustic events. This audio analysis approach enables detection and analysis of snoring sounds from a full night in order to produce quantified measures for objective follow-up of patients. 相似文献5.
Dafna Hirsch 《Ethnic and racial studies》2013,36(2):275-292
According to Nira Yuval-Davis some of the most important ways in which women are involved in national projects concern their capacity as biological and cultural reproducers of the nation and guardians of its boundaries. In this article I argue that Jewish women in Mandate Palestine not only guarded and reproduced national boundaries, but also redefined them. Middle-class women's organizations acted as agents of ‘nationalization’ and westernization among Mizrahi (lit. Oriental) Jewish communities, who were largely excluded from the imagined community of the nation by Ashkenazi Zionists. I explain the conjunction of gender and ethnicity in the Zionist nation-building project through the life and letters of journalist and social activist Hannah Helena Thon. Two main factors serve as an explanation: the countries from which the leaders of the organizations emerged and their traditions of social work; and the position of middle-class women in the Jewish social field. 相似文献
6.
7.
Zachary A. Bornholdt Andrew S. Herbert Chad E. Mire Shihua He Robert W. Cross Anna Z. Wec Dafna M. Abelson Joan B. Geisbert Rebekah M. James Md Niaz Rahim Wenjun Zhu Viktoriya Borisevich Logan Banadyga Bronwyn M. Gunn Krystle N. Agans Ariel S. Wirchnianski Eileen Goodwin Kevin Tierney John M. Dye 《Cell host & microbe》2019,25(1):49-58.e5
8.
Polarizing near-field scanning optical microscopy (NSOM) was applied for visualization of lipid coagel structures. The technique
ensures obtaining polarization contrast images at micro- and nanoscale resolution. Comparison to the polarizing light microscopy
images revealed that the same fractal structural organization persists also at submicron scale, at the level of primary ordered
structures creation. Many long birefringent needle-shaped primary crystallites were imaged in the corn oil:monoglyceride samples,
and lower amount of smaller oval-shaped primary crystallites—in the olive oil:monoglyceride samples. Unlike atomic force microscopy,
polarizing NSOM brought direct evidence on the physical state of specific features. Compared to the polarizing light microscopy,
polarizing NSOM provided additional information on the structural organization of oil–monoglyceride coagels at the micro-
and submicron scale. 相似文献
9.
A fault detection service for wide area distributed computations 总被引:6,自引:0,他引:6
Paul Stelling Cheryl DeMatteis Ian Foster Carl Kesselman Craig Lee Gregor von Laszewski 《Cluster computing》1999,2(2):117-128
The potential for faults in distributed computing systems is a significant complicating factor for application developers.
While a variety of techniques exist for detecting and correcting faults, the implementation of these techniques in a particular
context can be difficult. Hence, we propose a fault detection service designed to be incorporated, in a modular fashion, into
distributed computing systems, tools, or applications. This service uses well-known techniques based on unreliable fault detectors
to detect and report component failure, while allowing the user to trade off timeliness of reporting against false positive
rates. We describe the architecture of this service, report on experimental results that quantify its cost and accuracy, and
describe its use in two applications, monitoring the status of system components of the GUSTO computational grid testbed and
as part of the NetSolve network-enabled numerical solver.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
10.
Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles 总被引:21,自引:0,他引:21
Martin MP Nelson G Lee JH Pellett F Gao X Wade J Wilson MJ Trowsdale J Gladman D Carrington M 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(6):2818-2822
NK cell activity is partially controlled through interactions between killer Ig-like receptors (KIR) on NK cells and their respective HLA class I ligands. Independent segregation of HLA and KIR genes, along with KIR specificity for particular HLA allotypes, raises the possibility that any given individual may express KIR molecules for which no ligand is present. Inhibitory receptor genes KIR2DL2/3 and KIR2DL1 were present in nearly all subjects sampled in this study, whereas their respective activating homologs, KIR2DS2 and KIR2DS1, are each present in about half of the subjects. In this work we report that subjects with activating KIR2DS1 and/or KIR2DS2 genes are susceptible to developing psoriatic arthritis, but only when HLA ligands for their homologous inhibitory receptors, KIR2DL1 and KIR2DL2/3, are missing. Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or T) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis. 相似文献