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1.
COONEY AUSTIN J.; KATZ DEBORAH; HUMMELKE GEOFFREY C.; JACKSON KATHY J. 《Integrative and comparative biology》1999,39(4):796-806
Germ Cell Nuclear Factor (GCNF) is an orphan member of the nuclearreceptor gene superfamily. Much has been understood about thefunctioning of GCNF which represents a candidate receptor fora novel hormonal signalling pathway. GCNF is not closely relatedto other members of the nuclear receptor superfamily and formsits own branch within the superfamily tree. It has a uniqueexpression pattern that spans both embryonic and adult stagesof development. In the adult, it is expressed in the germ cells:oocytes and spermatogenic cells as well as specific neuronalcells within the brain. In the embryo, GCNF expression is turnedon after gastrulation in all germ layers the ectoderm, mesodermand endoderm. An antero-posterior gradient of GCNF is establishedin the neuroectoderm of the embryo, suggesting a role in regulationof neuronal and germ cell development. Regulation of physiologicalprocesses by a nuclear receptor is achieved through regulationof gene expression. GCNF is the only nuclear receptor to specifcallybind to DR0 hormone response elements to regulate gene expression.In the absense of a ligand, GCNF represses gene expression.GCNF is capable of regulating the expression of the protaminegenes in a response element-dependent manner. At present theligand for GCNF is unknown, but it is hypothesized that GCNFis a receptor for a novel hormonal signalling pathway that effectsits biological response by regulating the expression of a subsetof genes containing DR0 response elements. 相似文献
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BLAUSTEIN JEFFREY D.; OLSTER DEBORAH H.; TETEL MARC J. 《Integrative and comparative biology》1993,33(2):219-228
SYNOPSIS. The ovarian steroid hormones, estradiol and progesterone,act in the guinea pig brain to regulate the expression of sexualbehavior. In studies of the cellular mechanisms of steroid hormoneaction, we have used an immunocytochemical technique to studythe regulation of these receptors in different neuroanatomicalregions. We have observed that progestin receptor-immunoreactivityin cells in certain neuroanatomical regions are more responsiveto particular steroid hormone treatments than are cells in otherregions. Similarly, we have observed selective regulation ofprogestin receptor-immunoreactivity in neurons identified onthe basis of their neuropeptide content. Finally, in the rostralpart of the ventrolateral hypothalamus, a site involved in hormonalregulation of female sexual behavior, estrogen receptor-immunoreactiveneurons that have dopamine-ß-hydroxylase varicositiesclosely-associated have higher levels of immunostaining forestrogen receptors than neurons without this relationship. Takentogether, these studies demonstrate the possibility of studyingthe microregulation of steroid hormone receptors in subsetsof neurons defined by neuroanatomical location, neuropeptide/neurotransmittercontent, afferent input and projection sites. The ability tostudy interactions among different systems at the cellular levelmay help us to understand more clearly the cellular processesinvolved in hormonal regulation of fundamental neuroendocrineprocesses, including the neuroendocrine regulation of sexualbehavior 相似文献
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CLEMENS KÜPPER GAVIN J. HORSBURGH DEBORAH A. DAWSON RICHARD FFRENCH‐CONSTANT TAMS SZKELY TERRY BURKE 《Molecular ecology resources》2007,7(1):35-39
We isolated 45 new Kentish plover (Charadrius alexandrinus) microsatellite loci. These were tested for polymorphism in 42 Kentish plovers breeding in the Çukurova Delta, Turkey. Thirty‐six of the 45 loci were polymorphic with observed heterozygosity varying between 0.22 and 0.93. Genotypes of individuals of known sex indicated that two loci were sex‐linked (Calex‐26 is located on the Z chromosome and Calex‐31 on the W chromosome). Additionally, we tested all loci for amplification in four other species of Charadridae (Kittlitz's plover, Madagascar plover, three‐banded plover and white‐fronted plover). On average 34 loci amplified per species (range 29–36). 相似文献
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Epiphytic diatoms in two freshwater maritime Antarctic lakes 总被引:1,自引:0,他引:1
SUMMARY.
- 1 An ecological study of two small maritime Antarctic lakes on Signy Island, South Orkney Islands, was undertaken from January 1986 to March 1987. Analysis of diatom counts from the lakes provided examples of oligotrophic and mesotrophic ecosystems.
- 2 A diverse community of 104 epiphytic taxa was identified. Twenty-eight taxa had a percentage abundance greater than 1% in both lakes. Distinctive dominant taxa were identified from each lake.
- 3 A variety of ordination techniques was performed on the abundance data and a principal components analysis demonstrated differences in the diatom assemblages between the two lakes. Clear separations of sites and species were evident between the lakes, and accounted for the greatest percentage variance.
- 4 Species composition varied with depth within each lake and was also important in influencing changes in assemblage composition between sites.
- 5 A redundancy analysis indicated that species composition was correlated to concentrations of nitrogen and phosphorus but the total variance accounted for by the four physical and chemical factors measured was low (24%).
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Association of Induced Frameshift Mutagenesis and DNA Replication in <Emphasis Type="Italic">Escherichia coli</Emphasis> 总被引:4,自引:0,他引:4
The induction of frameshifts in E. coli seems to be associated with chromosome replication. 相似文献
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CHRISTOPHER GRAHAM LAING TIMOTHY GEORGE SHREEVE DEBORAH MARIE ELIZABETH PEARCE 《Global Change Biology》2008,14(4):916-924
The quantification of greenhouse gas sources and sinks is important to understanding the impact of climate change. Methane (CH4) is a potent greenhouse gas, which, on a global scale, is released largely as a product of anaerobic microbial decomposition and predominantly from wetlands. A zone of intense CH4 production just below the water table is thought to contribute significantly to the overall flux from peat bogs. We describe the use of membrane inlet quadrupole mass spectrometry (QMS) to confirm the existence of bubbles, their gaseous concentrations and their localization at a fine spatial resolution within intact peat cores. We use the distribution of the noble gas argon (Ar) and the distinct QMS responses to dissolved and gaseous (bubble) phases to identify trapped bubbles with a resolution of 0.6 mm. Bubbles with CH4 concentrations of up to 20 kPa were widely distributed in the upper 300 mm of the cores with ~11% of all profiles comprising bubbles. The dissolved concentrations responsible for the bubbles were on average 83±80 μm , indicating lower concentrations relative to other QMS studies. We suggest that if the distinction between dissolved and gaseous phases is not made in studies of CH4 within peat profiles then the prominence of bubbles is likely to result in overestimates of dissolved CH4 concentrations. Fluxes of CH4 from peat as a result of drawdown or other perturbation are likely to be large, rapid and short lived because of bubble burst, and also larger than from peat without bubbles. We suggest that the dynamics of fluxes need to be modelled taking into account both gaseous and dissolved phases. Estimates of potential fluxes that assume CH4 is dissolved are likely to overestimate fluxes if the gaseous phase has not been taken into account. 相似文献
10.
DEBORAH SMITH SANDER VAN RIJN JOH HENSCHEL TRINE BILDE YAEL LUBIN 《Biological journal of the Linnean Society. Linnean Society of London》2009,97(2):235-246
We used DNA fingerprints to determine whether the population structure and colony composition of the cooperative social spider Stegodyphus dumicola are compatible with requirements of interdemic ('group') selection: differential proliferation of demes or groups and limited gene flow among groups. To investigate gene flow among groups, spiders were collected from nests at 21 collection sites in Namibia. Analysis of molecular variance showed a small but highly significant differentiation among geographic regions (ΦPT = 0.23, P = 0.001). Thirty-three nests at four collection sites (6–10 spiders per nest, 292 individual spiders) were investigated in more detail to evaluate variation within and among colonies and among collection sites. In these 33 nests, an average of 15% of loci (fingerprint bands) were polymorphic among nestmates; 16% of observed variance was partitioned among collection sites, 48% among nests within a collection site, and 36% among individuals within nests. Spatial autocorrelation analyses of spiders at three collection sites showed that the maximum extent of detectable spatial autocorrelation among individuals was approximately 30 m, indicating dispersal over greater distances is not typical. These results indicate limited gene flow among nests, as well as spatial structuring at the level of regions, local populations, and nests, compatible with interdemic selection. © 2009 The Linnean Society of London, Biological Journal of the Linnean Society , 2009, 97 , 235–246. 相似文献