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Coskun-Cevher S. Altundas A. Balabanli B. Kaltalioglu K. Logoglu E. Tastan H. 《Biology Bulletin》2022,49(5):538-547
Biology Bulletin - This work presents the positive effects of synthesized novel 3-cyano-N-pyridinyl acetamide derivatives on the wound healing process. This work also analyzes their putative action... 相似文献
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Huseyin Sahin Kaan Kaltalioglu Zuleyha Erisgin Sule Coskun-Cevher Sevgi Kolayli 《化学与生物多样性》2023,20(5):e202300305
This study focused on the protective effects of different types of propolis extracts on gastric mucosa in indomethacin-induced rats. The animals were divided into nine groups: control, negative control (ulcer), positive control (omeprazole), and experimental groups, which were summarized by 200, 400, and 600 mg/kg, bw for aqueous-based and ethanol, respectively. According to the histopathological evaluation, more than others, the doses of 200 and 400 mg/kg of aqueous-based propolis extracts had different degrees of positive effects on the gastric mucosa. Generally, the biochemical analyses of the gastric tissue showed a correlation with microscopic evaluations. According to the phenolic profile analysis, while pinocembrin (684.34±1.70 μg/ml) and chrysin (540.54±9.06 μg/ml) were the most abundant phenolics in the ethanolic extract, ferulic acid (53.77±0.07 μg/ml) and p-coumaric acid (52.61±0.42 μg/ml) dominated the aqueous-based extract. Also, the total phenolic content (TPC), total flavonoid content (TFC), and DPPH radical scavenging activity of the ethanolic extract showed almost nine-fold superiority compared to the aqueous-based extracts. Based on data from preclinical data, it was decided that the best doses for the main goal of the study were 200 mg and 400 mg/kg, bw for aqueous-based propolis extract. 相似文献
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