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1.
Purification and characterization of human placental ferredoxin 总被引:1,自引:0,他引:1
A ferredoxin-type iron-sulfur protein was isolated from human placenta mitochondria. The properties of the purified protein were very similar to those of adrenal ferredoxin (adrenodoxin), and immunological cross-reactivity with polyclonal antibodies to bovine adrenodoxin was observed. The N-terminal amino acid sequence and the visible absorption spectrum were identical to bovine adrenodoxin. The molecular mass as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Mr approximately 13,500), however, is slightly smaller than that of adrenodoxin, and the C-terminal sequence is different. Human placental ferredoxin can substitute for bovine adrenodoxin in reactions reconstituted with bovine adrenal enzymes which catalyze the side chain cleavage of cholesterol to pregnenolone and the 11 beta-hydroxylation of deoxycorticosterone to corticosterone. 相似文献
2.
P Soding J P Coghlan D A Denton W F Graham T J Humphery B A Scoggins 《Journal of steroid biochemistry》1983,18(2):173-177
The blood clearance rate (BCR) of aldosterone, cortisol, 17 alpha-hydroxyprogesterone (17 alpha OHP) and 17 alpha, 20 alpha-dihydroxy-4-pregnen-3-one (17 alpha 20 alpha OHP) has been measured in conscious sheep prior to and after 5 or 6 days ACTH treatment. ACTH increased the BCR of cortisol but did not change the BCR of the other three steroids. 17 alpha OHP had a BCR greater than liver blood flow suggesting extra-hepatic metabolism. In vivo conversion of 17 alpha OHP to 17 alpha 20 alpha OHP by ovine red cells has been shown to be a significant site of this metabolism. It is suggested that this conversion of 17 alpha OHP to 17 alpha 20 alpha OHP may be important in the expression of the "hypertensionogenic" effect of 17 alpha OHP. 相似文献
3.
Hill Prudence A. Coghlan John P. Butkus Aldona Ryan Graeme B. 《Cell and tissue research》1983,229(3):515-531
Cell and Tissue Research - The effects of alterations in sodium status upon the morphology of the adrenal zona glomerulosa in sheep have been examined qualitatively and quantitatively, using... 相似文献
4.
5.
The molecular evolution of mammalian Y-linked DNA sequences is of special
interest because of their unique mode of inheritance: most Y- linked
sequences are clonally inherited from father to son. Here we investigate
the use of Y-linked sequences for phylogenetic inference. We describe a
comparative analysis of a 515-bp region from the male sex- determining
locus, Sry, in 22 murine rodents (subfamily Murinae, family Muridae),
including representatives from nine species of Mus, and from two additional
murine genera--Mastomys and Hylomyscus. Percent sequence divergence was
< 0.01% for comparisons between populations within a species and was
0.19%-8.16% for comparisons between species. Our phylogenetic analysis of
12 murine taxa resulted in a single most- parsimonius tree that is highly
concordant with phylogenies based on mitochondrial DNA and allozymes. A
total evidence tree based on the combined data from Sry, mitochondrial DNA,
and allozymes supports (1) the monophyly of the subgenus Mus, (2) its
division into a Palearctic group (M. musculus, M. domesticus, M.
spicilegus, M. Macedonicus, and M. spretus) and an Oriental group (M.
cookii++, M. cervicolor, and M. caroli), and (3) sister-group relationships
between M. spicilegus and M. macedonicus and between M. cookii and M.
cervicolor. We argue that Y- chromosome DNA sequences represent a valuable
new source of characters for phylogenetic inference.
相似文献
6.
J. D. Penschow Michelle E. Giles John P. Coghlan R. T. Fernley 《Histochemistry and cell biology》1997,107(5):417-422
Carbonic anhydrase VI (CA VI) is a secreted enzyme produced predominantly by serous acinar cells of submandibular and parotid
glands. We have investigated the developmental pattern of CA VI production by these glands in the sheep, from fetal life to
adulthood, using immunohistochemistry. Also, a specific radioimmunoassay for CA VI was used to measure changes in enzyme expression
in the parotid gland postnatally. CA VI is detectable by immunohistochemistry in parotid excretory ducts from 106 days gestation
(term is 145 days), in striated ducts from 138 days and in acinar cells from 1 day postnatal. The duct cell content of CA
VI declined as the acinar cell population increased, a feature also of CA VI immunoreactivity in the submandibular gland.
Production of CA VI by submandibular duct cells was detectable initially at 125 days gestation, and acinar production was
not seen before 29 days post-natal. Apart from the differing ontogeny of CA VI production in ducts and acini of parotid and
submandibular glands, there was a parallel pattern of CA VI expression during the development of these major salivary glands.With
the development of the acinar tissues in the postnatal lamb, there was a dramatic increase (about 600-fold) in the level of
expression of CA VI in the parotid gland between days 7 and 59 as measured by radioimmunoassay.
Accepted: 19 December 1996 相似文献
7.
R T Mason J P Coghlan D A Denton D W Fei B A Scoggins J A Whitworth 《Prostaglandins》1984,27(4):527-534
The haemodynamic and renin responses to prostacyclin (PGI2) infusion were examined in sheep during sodium depletion and dietary sodium restriction. The haemodynamic effects of PGI2 infusion in sodium depleted and sodium restricted sheep were similar to those obtained in the sodium replete animal. The renin proportionate response to PGI2 was not altered by sodium restriction but blunted by sodium depletion, compatible with the hypothesis that endogenous PGI2 is high in Na depletion. 相似文献
8.
The acrosomic status of spermatozoa prepared for IVF has been evaluated by means of immunofluorescence test from Fenichel and Hsi using calcium A 23187 ionophore as inductor of acrosome reaction (AR). The spontaneous AR remains slight, even after 6 hour-incubation in Menezo B2 (6,8+2,7%). The response to ionophore, moderate before (11,2+9%), frankly increases after a 6h-capacitation (28,9+8,3%) in a group of 25 IVF couples (tubal indication, normal semen, positive fertilization). Nevertheless, it remains slight or null in 4 cases of unexplained repeated failure of fertilization. The response to ionophore A 23187 allows to explore the kinetics of capacitation of spermatozoa and their ability to perform AR. Its significance in terms of fecondance remains to be precised. 相似文献
9.
S F Abraham J P Coghlan D A Denton J G McDougall D R Mouw B A Scoggins 《Quarterly journal of experimental physiology and cognate medical sciences》1976,61(3):185-192
Forty-eight hours of sodium depletion by acute cannulation of a parotid duct, via the buccal papilla, in the sheep, resulted in a progressive decrease in salivary secretion rate, salivary, urinary and plasma [Na] and no change in plasma [K]. In the first 24 h of Na depletion water intake was significantly increased. As normal sheep parotid saliva [Na] is higher than plasma [Na] and salivary loss over the first 24 h represented Na loss in excess of water relative to extracellular proportions, increased water intake was not osmotically induced. However, the animals did not replace their water deficit on either of the 2 days of Na depletion. This would appear to be valuable experimental model of increased water intake probably induced by hypovaolaemia, but uncomplicated concurrent osmotic stimuli, or any other factors which might result with the other commonly used experimental stimuli of thirst such as haemorrhage. 相似文献
10.
Naiti Morales Amy Rose Coghlan Gonzalo Hayden Paula Guajardo 《Journal of fish biology》2019,95(2):642-646
On 20 December 2017, a mature Triaenodon obesus was observed at Hanga Roa Bay, Rapa Nui (Easter Island) at c.18 m depth. This observation increases both the range of T. obesus in the Pacific Ocean and the number of elasmobranch species at Rapa Nui. In combination with other recent sightings further extending the southern range of this species during the Austral summer, sea surface temperature is suggested as key to southern dispersal. 相似文献