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Nagy K Marschalkó M Kemény B Horváth A 《Acta microbiologica et immunologica Hungarica》2005,52(3-4):385-396
The mechanisms leading to the development of eosinophilia were investigated in 65 patients with immunodermatological disorders, including the role of eosinophilotactic cytokines and the possible involvement of human T-cell leukemia virus, HTLV. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. Increased level of GM-CSF was detected in 33% of disorders studied. Elevated level of IL-5 and eotaxin was detected in 27% and 30%, respectively, of patients with bullous diseases. Elevated level of GM-CSF and eotaxin was found in 33% and 46%, respectively, of patients with inflammatory diseases. Neither of the four cytokines, however proved to be responsible alone or together for the induction of eosinophilia. The possible indirect role of human retroviruses through induction of eosinophilic chemotactic cytokines is hypothesized. 相似文献
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Ana Carolina Vieira Cidnei Marschalk Débora Carina Biavatti Carla Andréia Lorscheider Rosane Marina Peralta Flavio Augusto Vicente Seixas 《Bioinformation》2015,11(5):224-228
The herbicide diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is used in many agricultural crops and non-crop areas worldwide,
leading to the pollution of the aquatic environment by soil leaching. White rot fungi and its lignin modifying enzymes, peroxidases
and laccases, are responsible for its degradation. Therefore, it is of interest to explore the potential use of Ceriporiopsis subvermispora
laccase (CersuLac1) in the biotransformation of this herbicide by using its enzyme laccase. However, the structure of laccase from
Ceriporiopsis subvermispora is still unknown. Hence, a model of laccase was constructed using homology modeling. The model was
further used to dock p-methylbenzoate in the presence of four copper ions to analyze molecular basis of its binding and interaction.
The ligand-protein interaction is stereo-chemically favorable in nature. The presence of the single protonated Lys457 was necessary
for catalysis, being coordinated by a cupper ion. The best pose of diuron on CersuLac1 has a theoretical Ki of 2.91 mM. This is
comparable to the KM values for laccases from other organisms with similar compounds. Thus, we document the insights for the
potential use of laccase from Ceriporiopsis subvermispora in the biotransfrormation of diuron. 相似文献
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I Horváth K Király M Marschalkó 《Acta microbiologica Academiae Scientiarum Hungaricae》1979,26(4):273-275
Virulent Treponema pallidum has been shown to survive in KCN-containing artificial medium. Oxygen uptake being sensitive to cyanide, the observation indicates that treponemes do not have a cytochrome oxidase system. KCN had a killing effect only at a 15--30 mM final concentration. The data show that the Budapest strain of T. pallidum is an anaerobic organism. 相似文献
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