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Dragunova S. G. Reshetov I. V. Kosyreva T. F. Severin A. E. Khamidulin G. V. Shmaevsky P. E. Inozemtsev A. N. Popadyuk V. I. Kastyro I. V. Yudin D. K. Yunusov T. Yu. Kleyman V. K. Bagdasaryan V. V. Alieva S. I. Chudov R. V. Kuznetsov N. D. Pinigina I. V. Skopich A. A. Kostyaeva M. G. 《Doklady. Biochemistry and biophysics》2021,498(1):165-169
Doklady Biochemistry and Biophysics - The effects of septoplasty and sinus lifting simulation in rats on changes in the frequency domain of heart rate variability were compared. In the early... 相似文献
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Kazakova O. B. Smirnova I. E. Medvedeva N. I. Lopatina T. V. Chudov I. V. Sharipov A. R. Ziganshin A. S. Thao Tran Thi Phuong 《Russian Journal of Bioorganic Chemistry》2019,45(6):558-565
Russian Journal of Bioorganic Chemistry - The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was... 相似文献
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Kazakova OB Tret'iakova EV Kukovinets OS Tolstikov GA Nazyrov TI Chudov IV Ismagilova AF 《Bioorganicheskaia khimiia》2010,36(6):832-840
The synthesis of a new group of maleopimaric acid amides containing fragments of the methyl esters of amino acids, aliphatic amines, imidazole and N-methylpiperazine was carried out. Ozonolysis of methyl maleopimarate flows through the cleavage of double bond C18(19) and the disclosure of anhydrous cycle with formation of secotriacid. As a result of screening of anti-inflammatory and antiulcer activity of maleopimaric acid derivatives new effective compounds such as methyl esters of maleopimaric acid and product of ozonolysis - diterpenic secotriacid, maleopimaric acid amide with L-leucine were revealed. An important advantage of the compounds studied is the low toxicity and the presence of bidirectional activity in the absence of adverse effects on the animal. 相似文献
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O. B. Kazakova E. V. Tret’yakova O. S. Kukovinets G. A. Tolstikov T. I. Nazyrov I. V. Chudov A. F. Ismagilova 《Russian Journal of Bioorganic Chemistry》2010,36(6):762-770
The synthesis of a new group of maleopimaric acid amides containing fragments of methyl ethers of amino acids, aliphatic amines,
imidazole, and N-methylpiperazine was carried out. The ozonolysis of methylmaleopimarate occurs via the cleavage of the double bond C18(19)
and the opening of an anhydrous ring with the formation of secotriacid. As a result of the screening of the anti-inflammatory
and antiulcer activity of maleopimaric acid derivatives, new effective compounds such as maleopimaric acid and its methyl
ether, a product of ozonolysis—diterpenic secotriacid—and maleopimaric acid amide with L-leucine were found. An important advantage of the studied compounds is the low toxicity and the presence of bidirectional
activity in the absence of adverse effects on the animal. 相似文献
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O. B. Kazakova I. E. Smirnova H. Do Tkhi Tkhu Tkhankh Tra Nguen G. N. Apryshko O. S. Zhukova N. I. Medvedeva T. I. Nazyrov E. V. Tret’yakova I. V. Chudov A. F. Ismagilova K. Yu. Suponitsky D. V. Kazakov F. E. Safarov G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2013,39(2):202-210
The synthesis of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid was carried out and its structure was established by X-ray diffraction. The antineoplastic activity and the ability to induce apoptosis that were predicted by a PASS computer system, correlate well with the experimentally found cytotoxic activity towards the MeWo malignant cell line. The results of tests on animals showed that abietic acid and its (7R,8S)-epoxy-(13R,17R)-trioxolane derivative have anti-inflammatory and antiulcer activities in the absence of side effects. 相似文献
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O. B. Kazakova E. V. Tret’yakova I. E. Smirnova L. V. Spirikhin G. A. Tolstikov I. V. Chudov G. V. Bazekin A. F. Ismagilova 《Russian Journal of Bioorganic Chemistry》2010,36(2):257-262
Under the action of PCl5, the Beckman rearrangement of a 3: 1 mixture of Z- and E-isomeres of 18β-hydro-xydihydroquinopimaric acid resulted in 5′-caprolactam and isomeric caprolactams containing fragments
of cyclic ether. Z- and E-ketoximes were separated as acetates. Using a carrageenan inflammation model, we demonstrated that the anti-inflammatory
activity of quinopimaric acid derivatives was comparable with that of diclofenac. 相似文献
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