Architectonic and Diagnostic Significance of Hair Cuticle

Guard hair and spine architectonic were studied in 345 mammalian species using scanning electron microscopy. Comparative morphological analysis of the author's and published data was performed to systematize the available information. Original terminology and classification of the main hair and spine cuticle patterns have been proposed. The hair and spine cuticle structure patterns, their adaptability, and value for taxon identification are discussed.     

PET-CT在非完全实性肺结节中的应用价值

肺癌在中国恶性肿瘤的发病率位居第一,随着低剂量薄层CT在肺癌筛查中的广泛应用,临床发现更多表现为非完全实性结节的肺腺癌,目前众多研究使CT影像学特征和肺腺癌病理的关系得到更进一步的认知,虽然CT能对部分非完全实性结节做出定性和定位诊断,但仍有部分非完全实性结节诊断困难,PET-CT结合了病灶的代谢信息和精确的定位信息,从而提高对肺部结节诊断的敏感性、特异性、准确性,综合多个文献PET-CT在非完全实性结节中的诊断分期价值较CT无明显提升,却在评估预后和制定合适手术方案上可以起到一定的作用,本文就PET-CT在SSN中的应用价值进行阐述。     

Determining neuronal response of the rabbit thermoregulatory center to thermal stimulation

A classification was made of neuronal spike activity in the dorso- and ventromedial hypothalamic nuclei. Thermosensitive neurons in which response was accompanied by change in activity pattern could be identified with 0.95 probability by means of an algorithm based on this classification.I. V. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 20, No. 3, pp. 291–301, May–June, 1988.     

Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs

By multistep selection a set of clones and sublines possessing different levels of resistance to colchicine or adriablastin was obtained from the SV40-transformed Djungarian hamster cell lines, DM-15 and DM^cap. Resistance to both colchicine and adriablastin is associated with an alteration of plasma membrane permeability leading to a decreased uptake of various drugs (³H-colchicine, ³H-cytochalasin B, ³H-actinomycin D, ³H-puromycin, ³H-vinblastine, ¹⁴C-chloramphenicol). The DNA of cells highly resistant to cholchicine can transmit resistance only to low dosages of the drug. Comparison of DNAs from wild-type and resistant cells digested by restriction endonucleases revealed new classes of repeated DNA sequences in resistant cell lines. The degree of DNA repetition was correlated with the level of drug resistance. The repeated DNA sequences evidently represent parts of the genome that are amplified in resistant cells. The size of the amplified sequences is 200–250 kilobase pairs (kb). Cell lines highly resistant to colchicine contain amplified DNA, which like mitochondrial DNA replicate asynchronously with the main portion of the cellular DNA and related but not identical DNA sequences are amplified in independent cell lines selected for resistance to colchicine, adriablastin, and actinomycin D. These cell lines display similar patterns of alterations of plasma membrane permeability. The amplified DNA sequences may contain a gene or genes the overexpression of which leads to change in plasma membrane permeability and a development of resistance to various drugs.     

Effect of tetracycline group antibiotics on the barrier properties of the small intestine epithelium]

The effect of 5 tetracyclines on the barrier and transport properties of the small intestine epithelium was studied. The barrier properties were estimated by a change in the ionic selectivity and conductivity of the epithelium, as well as by enterocyte linkage. The current of the short circuit served the characteristics of the Na transport system state. Dimethylchlortetracycline, methacycline and oxytetracycline in concentrations of 10(-7) g/ml decreased the epithelium conductivity and increased the cell linkage. Tetracycline and methacycline in concentrations of 10(-9) g/ml had an analogous effect. The effect was observed 10--20 minutes after the start of incubation with the substance. No effect on the current of the short circuit was observed within the concentrations of 10(-4) to 10(-9) g/ml. It is suggested that the decreased conductivity and increased linkage are due to adsorption of the tetracycline molecules in the region of close cell contacts.     

Infectious morbidity in the USSR: its structure, levels, dynamics and economic significance

Taking well-grounded strategic decisions on the control of infectious diseases requires the knowledge of modern epidemiological situation with respect to the total infectious pathology. The structure, levels and dynamics of morbidity in infectious diseases, registered according to Form No. 85 (Infection), on the territory of the USSR are considered. Besides, the evaluation of the economic damage inflicted to the national economy of the USSR by infectious morbidity is presented.     

A New Species of Snailfishes (Liparidae) of the Genus Careproctus from the Northern Slope of the Aleutin Basin (Bering Sea)

Journal of Ichthyology - A new species of snailfishes Careproctus schmidti sp. nov. from the northwestern part of the Bering Sea is described. The specimen was caught in the mesobenthal of the...     

New Data on the Shortcrevice Eelpout Gymnelopsis brevifenestrata (Zoarcidae) from the Sea of Okhotsk

Journal of Ichthyology - Shortcrevice eelpout Gymnelopsis brevifenestrata (Zoarcidae, Gymnelinae) is an endemic species of the Sea of Okhotsk; until recently, it was known by 12 type specimens from...