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1.
Mathieu Arminjon Amer Chamseddine Vladimir Kopta Aleksandar Paunovi? Christine Mohr 《PloS one》2015,10(9)
We quickly form first impressions about newly encountered people guiding our subsequent behaviour (approach, avoidance). Such instant judgments might be innate and automatic, being performed unconsciously and independently to other cognitive processes. Lying detection might be subject to such a modular process. Unfortunately, numerous studies highlighted problems with lying detection paradigms such as high error rates and learning effects. Additionally, humans should be motivated doing both detecting others’ lies and disguising own lies. Disguising own lies might even be more challenging than detecting other people’s lies. Thus, when trying to disguise cheating behaviour, liars might display a mixture of disguising (fake) trust cues and uncontrolled lying cues making the interpretation of the expression difficult (perceivers are guessing). In two consecutive online studies, we tested whether seeing an increasing amount (range 0–4) of lying cues (LC) and non-lying cues (NLC) on a standard face results in enhanced guessing behaviour (studies 1 and 2) and that enhanced guessing is accompanied by slower responding (study 2). Results showed that pronounced guessing and slowest responding occurred for faces with an intermediate number and not with the highest number of LC and NLC. In particular, LC were more important than NLC to uncertain lying decisions. Thus, only a few LC may interfere with automatic processing of lying detection (irrespective of NLC), probably because too little lying cue information is yet available. 相似文献
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Chamseddine Derabli Imen Boualia Ahmed B. Abdelwahab Raouf Boulcina Chawki Bensouici Gilbert Kirsch Abdelmadjid Debache 《Bioorganic & medicinal chemistry letters》2018,28(14):2481-2484
In this work, we describe the preparation of some new Tacrine analogues modified with a pyranopyrazole moiety. A one-pot multicomponent reaction of 3-methyl-1H-pyrazol-5(4H)-one, aryl(or hetero)aldehydes, malononitrile and cyclohexanone involving a Friedländer condensation led to the title compounds. The synthesized heterocyclic analogues of this molecule were evaluated in vitro for their AChE and BChE inhibitory activities in search for potent cholinesterase enzyme inhibitors. Most of the synthesized compounds displayed remarkable AChE inhibitory activities with IC50 values ranging from 0.044 to 5.80?µM, wherein compounds 5e and 5j were found to be most active inhibitors against AChE with IC50 values of 0.058 and 0.044?µM respectively. Molecular modeling simulation on AChE and BChE receptors, showed good correlation between IC50 values and binding interaction template of the most active inhibitors docked into the active site of their relevant enzymes. 相似文献
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Ben Kridis-Rejeb Wala Ben Ayed-Guerfali Dorra Ammous-Boukhris Nihel Ayadi Wajdi Kifagi Chamseddine Charfi Slim Saguem Ines Sellami-Boudawara Tahia Daoud Jamel Khanfir Afef Mokdad-Gargouri Raja 《Molecular biology reports》2020,47(9):6507-6516
Molecular Biology Reports - Male Breast Cancer (MBC) is a rare and aggressive disease that is associated with genetic factors. Mutations in BRCA1 and BRCA2 account for... 相似文献
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Nabil A. Yassin Samar A. Muwakkit Ahmad O. Ibrahim Imad M. Kayim Mohammad-Zohair M. Habbal Nabil M. Chamseddine Khaled M. Musallam Ali I. Shamseddine 《Journal of applied genetics》2008,49(4):421-424
Gaucher disease (GD) is an autosomal recessive inborn error of metabolism, resulting from a deficiency of the enzyme glucocerebrosidase,
causing an accumulation of the glycolipid glucocerebroside within lysosomes of macrophages in the reticuloendothelial system.
Three major clinical forms have been assigned and more than 200 gene mutations have been identified. We herein report a Lebanese
boy born with a novel combined mutation L371V/Rec-NciI, who presented with moderate-severe type 1 GD. An overview of the clinical
and biomarker improvement following enzyme replacement therapy with imiglucerase is described in a follow-up of 30 months.
Imiglucerase seems to be efficacious in decreasing the severity of the disease associated with this mutation. However, a high
dose may be required to achieve optimal growth, platelet count, and hemoglobin level. 相似文献
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Imen Chamkha Emna Mkaouar-Rebai Hajer Aloulou Imen Chabchoub Chamseddine Kifagi Nourhene Fendri-Kriaa Thouraya Kammoun Mongia Hachicha Faiza Fakhfakh 《Biochemical and biophysical research communications》2011,(1):504
Mitochondria are essential for early cardiac development and impaired regulation of mitochondrial function was implicated in congenital heart diseases. We described a newborn girl with hypertrophic cardiomyopathy and profound hearing loss. The mtDNA mutational analysis revealed the presence of known polymorphisms associated to cardiomyopathy and/or hearing loss, and 2 novel heteroplasmic mutations: m.3395A > G (Y30C) occurring in a highly conserved aminoacid of the ND1 gene and the m.4316A > G located in the residue A54 of the tRNAIle gene. These 2 novel variations were absent in 150 controls. All these variants may act synergistically and exert a cumulative negative effect on heart function to generate the cardiomyopathy. 相似文献
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Chamkha I Mkaouar-Rebai E Aloulou H Chabchoub I Kifagi C Fendri-Kriaa N Kammoun T Hachicha M Fakhfakh F 《Biochemical and biophysical research communications》2011,404(1):504-510
Mitochondria are essential for early cardiac development and impaired regulation of mitochondrial function was implicated in congenital heart diseases. We described a newborn girl with hypertrophic cardiomyopathy and profound hearing loss. The mtDNA mutational analysis revealed the presence of known polymorphisms associated to cardiomyopathy and/or hearing loss, and 2 novel heteroplasmic mutations: m.3395A>G (Y30C) occurring in a highly conserved aminoacid of the ND1 gene and the m.4316A>G located in the residue A54 of the tRNA(Ile) gene. These 2 novel variations were absent in 150 controls. All these variants may act synergistically and exert a cumulative negative effect on heart function to generate the cardiomyopathy. 相似文献
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Chamseddine AH Miller FJ 《American journal of physiology. Heart and circulatory physiology》2003,285(6):H2284-H2289
Reactive oxygen species (ROS) derived from vascular NADPH oxidase are important in normal and pathological regulation of vessel growth and function. Cell-specific differences in expression and function of the catalytic subunit of NADPH oxidase may contribute to differences in vascular cell response to NADPH oxidase activation. We examined the functional expression of gp91phox on NADPH oxidase activity in vascular smooth muscle cells (SMC) and fibroblasts (FB). As measured by dihydroethidium fluorescence in situ, superoxide (O2-*) levels were greater in adventitial cells compared with medial SMC in wild-type aorta. In contrast, there was no difference in O2-* levels between adventitial cells and medial SMC in aorta from gp91phox-deficient (gp91phox KO) mice. Adventitial-derived FB and medial SMC were isolated from the aorta of wild-type and gp91phox KO mice and grown in culture. Consistent with the observations in situ, basal and stimulated ROS levels were reduced in FB isolated from aorta of gp91phox KO compared with FB from wild-type aorta, whereas ROS levels were similar in SMC derived from gp91phox KO and wild-type aorta. There were no differences in expression of superoxide dismutase between gp91phox KO and wild-type FB to account for these observations. Because gp91phox is associated with membranes, we examined NADPH-stimulated O2-. production in membrane-enriched fractions of cell lysate. As measured by chemiluminescence, NADPH oxidase activity was markedly greater in wild-type FB compared with gp91phox KO FB but did not differ among the SMCs. Confirming functional expression of gp91phox in FB, antisense to gp91phox decreased ROS levels in wild-type FB. Finally, deficiency of gp91phox did not alter expression of the gp91phox homolog NOX4 in isolated FB. We conclude that the neutrophil subunit gp91phox contributes to NADPH oxidase function in vascular FB, but not SMC. 相似文献
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de la Grange Pierre Jolly Ariane Courageux Charlotte Ben Brahim Chamseddine Leroy Pascale 《Molecular biology reports》2021,48(10):6729-6738
Molecular Biology Reports - Basal stem/progenitor cells of airway epithelium from chronic obstructive pulmonary disease (COPD) patients have a decrease in differentiation and self-renewal... 相似文献