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Y. Duangjitcharoen D. Kantachote M. Ongsakul N. Poosaran C. Chaiyasut 《World journal of microbiology & biotechnology》2009,25(2):315-321
A strain of Lactobacillus plantarum SS2 isolated from a fermented star fruit (Averrhoa carambola) beverage product in Thailand has been reported to have some probiotic properties, in vitro. In the present study, its in
vivo safety and gastrointestinal survival following oral administration to mice was investigated. The acute toxicity test
on ICR mice by force-feeding of a single dose of 109 and 1012 cells per mouse over 14 days after ingestion showed no adverse effects related to the normal behavior of the laboratory mouse.
Although the weight gains of the dosed mice were lower than the control they were still within normal values. There were no
significant differences in liver weight ratio or spleen weight index among tested mice and control mice and no evidence of
bacteremia. Live SS2 cells labeled with a fluorescent dye (cFDA-SE) and administered orally at 109 cells per mouse were shown to persist in the gastrointestinal tract for 7 days. Colonies similar to the SS2 were detected
in fecal samples from the test mice even though the fecal lactic acid bacterial count showed no significant difference in
any mice. The strain SS2 is therefore considered to be a possible alternative choice for an inoculum to produce fermented
plant beverages. 相似文献
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