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Moreira Camila Francisco Cassini-Vieira Puebla Canesso Maria Cecília Campos Felipetto Mariane Ranfley Hedden Teixeira Mauro Martins Nicoli Jacques Robert Martins Flaviano Santos Barcelos Lucíola Silva 《Probiotics and antimicrobial proteins》2021,13(3):709-719
Probiotics and Antimicrobial Proteins - Skin wounds are an important clinical problem which affects millions of people worldwide. The search for new therapeutic approaches to improve wound healing... 相似文献
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Michael Bös Rolf Canesso Noriko Inoue-Ohga Atsuko Nakano Yuki Takehana Andrew J. Sleight 《Bioorganic & medicinal chemistry》1997,5(12):2165-2171
O-Methylasparvenone (1) and asparvenone (2) were isolated from an Aspergillus parvulus Smith broth in a microbial screening for 5-HT2C ligands and found to be 5-HT2C antagonists. They represent the first nitrogen-free serotonin ligands. The absolute configuration of 1 was determined to be S by X-ray analysis of the corresponding Mosher-ester. A short and efficient synthesis of rac-1 was developed. This protocol was applied to the synthesis of derivatives of 1 and a structure-affinity relationship was established. 相似文献
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