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排序方式: 共有307条查询结果,搜索用时 31 毫秒
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Zahid H. Chohan Humayun Pervez A. Rauf Khalid M. Khan Ghulam M. Maharvi 《Journal of enzyme inhibition and medicinal chemistry》2013,28(2):161-168
A new series of antibacterial and antifungal triazine-derived mono- and di-substituted (symmetrical and unsymmetrical) Schiff-bases and their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments and IR and electronic spectral measurements. IR spectra indicated the ligands to act as tridentate towards divalent metal ions via a trazine-N, the azomethine-N and, indole-NH and deprotonated-O of salicylaldehyde. The magnetic moments and electronic spectral data suggest octahedral geometry for the Co(II), Ni(II) and Zn(II)complexes and square-pyramid for Cu(II) complexes. NMR spectral data of the ligands and their diamagnetic zinc(II) complexes well-define their proposed structures/geometries. Elemental analyses data of the ligands and metal complexes agree with their proposed structures/geometries. The synthesized ligands, along with their metal complexes were screened for their antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The results of these studies show the metal complexes to be more antibacterial/antifungal against two or more species as compared to the uncomplexed Schiff-base ligands. 相似文献
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James A. Cahill Richard E. Green Tara L. Fulton Mathias Stiller Flora Jay Nikita Ovsyanikov Rauf Salamzade John St. John Ian Stirling Montgomery Slatkin Beth Shapiro 《PLoS genetics》2013,9(3)
Despite extensive genetic analysis, the evolutionary relationship between polar bears (Ursus maritimus) and brown bears (U. arctos) remains unclear. The two most recent comprehensive reports indicate a recent divergence with little subsequent admixture or a much more ancient divergence followed by extensive admixture. At the center of this controversy are the Alaskan ABC Islands brown bears that show evidence of shared ancestry with polar bears. We present an analysis of genome-wide sequence data for seven polar bears, one ABC Islands brown bear, one mainland Alaskan brown bear, and a black bear (U. americanus), plus recently published datasets from other bears. Surprisingly, we find clear evidence for gene flow from polar bears into ABC Islands brown bears but no evidence of gene flow from brown bears into polar bears. Importantly, while polar bears contributed <1% of the autosomal genome of the ABC Islands brown bear, they contributed 6.5% of the X chromosome. The magnitude of sex-biased polar bear ancestry and the clear direction of gene flow suggest a model wherein the enigmatic ABC Island brown bears are the descendants of a polar bear population that was gradually converted into brown bears via male-dominated brown bear admixture. We present a model that reconciles heretofore conflicting genetic observations. We posit that the enigmatic ABC Islands brown bears derive from a population of polar bears likely stranded by the receding ice at the end of the last glacial period. Since then, male brown bear migration onto the island has gradually converted these bears into an admixed population whose phenotype and genotype are principally brown bear, except at mtDNA and X-linked loci. This process of genome erosion and conversion may be a common outcome when climate change or other forces cause a population to become isolated and then overrun by species with which it can hybridize. 相似文献
4.
S. Bushra M. Aslam M.A. Aziz M. Ahmed 《Archives Of Phytopathology And Plant Protection》2013,46(2):205-214
This study was carried out to see the impact of Angoumois grain moth (AGM) on different cultivars of barley so that we must grow resistant variety of barley or improve those which are susceptible to it. Eggs of Sitotroga cerealella (Oliv.) were collected and reared in incubators available in Stored Product Entomology Laboratory, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, under temperature 27 ± 2°C and 60 ± 2% relative humidity. For the experiment, five different cultivars of barley; Sanober-96, Jau-83, Soorab-96, ICBA and Sterling were selected for AGM feed. After an interval of 30, 60 and 90 days of infestation, percentage damage and weight loss in grains were determined. After carrying out laboratory and field germination tests, viability of different cultivars were checked. Damage was maximum in variety Soorab (99.38%), which becomes susceptible while it was minimum in Sanober-96 (90.62%), which becomes resistant. Weight loss was maximum in variety Soorab (49.71%), which becomes susceptible and was minimum in Sanober-96 (45.32%), which becomes resistant. Damage was positively correlated with weight loss and negatively correlated with seed germination. In germination tests, on filter paper, maximum germination was found in variety Sterling (3%) which becomes resistant and it was minimum in ICBA which becomes susceptible (0%). In sand germination test, maximum seeds germinated in variety Sanober-96 (2%), and minimum seeds germinated in ICBA (0%). By calculating the percentage of losses of different cultivars, it was found that none of cultivars proved itself completely resistant or susceptible. 相似文献
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The economic loss due to pest attack in stored commodities is a serious problem worldwide. About 200 insect species attack stored commodities. These insect pests are responsible for quantitative and qualitative losses in cereal grains. Among the stored grain pests, Angoumois grain moth, Sitotroga cerealella is considered as common, top of the list and most destructive pest of cereal grains. Its infestation starts in the standing crop and continues in storage. Although there are many control strategies, our need is some effective, cheap and readily available strategy for safe storage. This review presents different ways by which S. cerealella can be controlled. In this paper, a list of approaches is given which are used to improve the protection of stored grains against S. cerealella attack. These approaches include use of edible oils, containers, synthetic chemicals, agricultural waste materials, plant derivatives, bacterial protoxins, biopesticides, biocontrol enhancers and semiochemicals. If these tactics are followed as combined strategies in a compatible manner, they can provide us an integrated pest management programme for the efficient control of S. cerealella in cereal grains. 相似文献
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The lonchaeid fly Silba capsicarum is recorded for the first time from the island of Java where it is considered a potential pest of chilli pepper. The taxonomy and ecology of the species is reviewed and comparisons are drawn with Lonchaeidae attacking Capsicum spp. in the Neotropics. Initial results on the level of infestation in Java are provided. 相似文献
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Chohan ZH Pervez H Khan KM Rauf A Supuran CT 《Journal of enzyme inhibition and medicinal chemistry》2004,19(1):51-56
A method is described for the preparation of novel cephalexin-derived furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-containing compounds showing potent antibacterial activity. The binding of these newly synthesized antibacterial agents with metal ions such as cobalt(II), copper(II), nickel(II) and zinc(II) has been studied and their inhibitory properties against various bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae are also reported. These results suggest that metal ions to possess an important role in the designing of metal-based antibacterials and that such complexes are more effective against infectious diseases compared to the uncomplexed drugs. 相似文献
10.
An in vivo study of the effects of pentachlorophenol was carried out with a pre-acclimatized fish species, Heteropneustes fossilis, using four sub-lethal concentrations, 0.1, 0.2, 0.3 and 0.4 ppm, and three sampling times, 48, 72 and 96 h. Cytogenetic preparations were stained by the haematoxylin-eosin technique. The incidence of micronuclei was scored by a manual and an automated method. Small-sized micronuclei appeared in the cytoplasm in addition to the main nucleus. The frequency of micronucleated erythrocytes peaked at 4 days (96 h) exposure. The percentage of single micronuclei increased with longer exposures. The Mann-Whitney U test showed all micronuclei frequencies were significantly different from control (P<0.05). No statistical difference was observed between scores obtained by the manual and automated methods. A linear relationship between the percentage of micronucleated erythrocytes and dose was confirmed at all levels. Computer image analysis of morphological variations of erythrocytes indicated a 1:5 ratio of micronuclei and main nucleus accompanied by a reduction in cell volume by 600 dot units. Pentachlorophenol-mediated genotoxicity was confirmed in this fish for the first time. Possible consequences of genotoxicity and cytotoxicity are discussed. 相似文献