全文获取类型
收费全文 | 10025篇 |
免费 | 1376篇 |
国内免费 | 3743篇 |
出版年
2024年 | 96篇 |
2023年 | 263篇 |
2022年 | 410篇 |
2021年 | 481篇 |
2020年 | 451篇 |
2019年 | 503篇 |
2018年 | 346篇 |
2017年 | 333篇 |
2016年 | 381篇 |
2015年 | 576篇 |
2014年 | 791篇 |
2013年 | 708篇 |
2012年 | 997篇 |
2011年 | 910篇 |
2010年 | 721篇 |
2009年 | 710篇 |
2008年 | 836篇 |
2007年 | 836篇 |
2006年 | 721篇 |
2005年 | 674篇 |
2004年 | 545篇 |
2003年 | 445篇 |
2002年 | 383篇 |
2001年 | 273篇 |
2000年 | 250篇 |
1999年 | 193篇 |
1998年 | 133篇 |
1997年 | 89篇 |
1996年 | 56篇 |
1995年 | 57篇 |
1994年 | 41篇 |
1993年 | 36篇 |
1992年 | 48篇 |
1991年 | 44篇 |
1990年 | 55篇 |
1989年 | 61篇 |
1988年 | 40篇 |
1987年 | 42篇 |
1986年 | 39篇 |
1985年 | 27篇 |
1984年 | 31篇 |
1983年 | 41篇 |
1982年 | 47篇 |
1981年 | 45篇 |
1980年 | 21篇 |
1979年 | 20篇 |
1978年 | 26篇 |
1977年 | 28篇 |
1976年 | 23篇 |
1974年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Modern nutritional studies have found that diverse diets are linked to lower infant mortality rates and longer life expectancies in humans. This is primarily because humans require more than fifty essential nutrients for growth and cell maintenance and repair; most of these essential nutrients must come from outside food sources rather than being manufactured by the body itself; and a diversity of food types is required to consume the full suite of essential nutrients necessary for optimal human health. These principles and their related affects on human adaptations and demography are the hallmarks of a theoretical paradigm defined as nutritional ecology. This essay applies concepts derived from nutritional ecology to the study of human evolution. Principles of nutritional ecology are applied to the study of the Middle‐to‐Upper Paleolithic transition in order to broadly illustrate the interpretive ramifications of this approach. At any stage in human evolution, those hominid populations that chose to diversify their subsistence base may have had a selective advantage over competitors who restricted their diet principally to one food type, such as terrestrial mammals. 相似文献
2.
3.
Plant and Soil - Agricultural practices often have persistent effects on soil physicochemical properties and soil biota, which can feedback to influence plant performance. We investigated... 相似文献
4.
5.
Bryan M. Turner 《Chromosoma》1982,87(3):345-357
A mouse monoclonal IgM antibody against the core histone H2B has been shown, by indirect immunofluorescence, to stain metaphase chromosomes from a variety of cultured cell types. Experiments carried out with human HeLa cells showed that the intensity of staining varied along the length of chromosome arms giving in some cases a rudimentary banded staining pattern. Considerable variation in staining intensity was noted between individual chromosomes and between different metaphase spreads. It was noted that chromosomes having a more swollen appearance stained more intensely than those with a more compact structure, which were often unstained. Preincubation of unfixed metaphase chromosomes in buffered salt solutions virtually eliminated the cell to cell and chromosome to chromosome variation in staining, even when no visible effect on chromosome morphology was caused by such treatment. It is concluded that the determinant recognised by antibody HBC-7 is ubiquitous but is inaccessible in some chromosomes or chromosome regions. Digestion of purified chromatin (primarily interphase) with DNAase 1 or micrococcal nuclease resulted in a several-fold increase in the binding of antibody HBC-7 measured by solid-phase radioimmunoassay. This increase was abolished by subsequent treatment with trypsin, which suggests that the antigenic determinant recognised by antibody HBC-7 lies in the trypsin-sensitive N-terminal region of nucleosomal H2B. As the cationic N-terminal regions of the core histones are involved in DNA binding, it is likely that the accessibility of the determinant recognised by antibody HBC-7 is influenced by the relationship between the core histones and their associated DNA. 相似文献
6.
7.
Willoughby de Broke Rudyard Kipling Hugh Elliot E. Ray Lankester Leonard Hill Laurence R. Philipps Wm. Arbuthnot Lane James Crichton-Browne H. Bryan Donkin Francis Lloyd R. A. Lyster John MacAlister F. W. Mott William Osler C. W. Saleeby J. H. Sequeira Humphry Rolleston Hugh Wansey Bayly 《BMJ (Clinical research ed.)》1919,2(3074):725
8.
Susanne Berglund Bryan J. Egner Henrik Gradén Joakim Gradén David G.A. Morgan Tord Inghardt Fabrizio Giordanetto 《Bioorganic & medicinal chemistry letters》2009,19(15):4268-4273
Herein, we disclose the discovery and optimization of 2-piperidin-4-yl-acetamide derivatives as MCH-R1 antagonists. Structural investigation of piperidin-4-yl-amide and piperidin-4-yl-ureas identified 2-piperidin-4-yl-acetamide-based MCH-R1 antagonists with outstanding in vivo efficacy but flawed with high affinity towards the hERG potassium channel. While existing hERG SAR information was employed to discover highly potent MCH-R1 antagonists with minimized hERG inhibition, additional hurdles prevented their subsequent clinical exploration. 相似文献
9.
10.
急性脑梗死约占全部脑卒中的70%,病死率和致残率高,且极易复发。但目前针对急性脑梗死在时间窗内溶栓、抗凝等治疗手段不能从根本上切实有效地修复受损脑组织,且伴有出血等风险。寻找脑梗死形成发展的原因并予以治疗迫在眉睫。酸中毒是引起缺血性脑损伤的重要机制。大量实验研究表明,酸中毒能加重神经元的缺血性损伤,且其梗死面积与酸中毒的程度直接相关。但缺血产生的酸中毒如何引起神经元损伤的确切机制尚不明确。最近研究发现酸中毒能激活一种在中枢及周围神经中广泛存在的膜通道,即酸敏感离子通道,它对Ca2+通透,能引起细胞内Ca2+超载,同时能激活胞内酶引起细胞内蛋白质、脂类及核酸的降解,加重缺血后脑损伤。本文就酸敏感离子通道1a与脑梗死做一综述。 相似文献