排序方式: 共有40条查询结果,搜索用时 15 毫秒
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Li Ming Leong Paul M. Brickell 《The international journal of biochemistry & cell biology》1996,28(12):1293-1296
Bone morphogenetic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-β (TGF-β) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. Although discovered because it stimulates bone formation in adult mammals, BMP-4 has important roles as a signalling molecule in embryonic tissues, including the developing central and peripheral nervous system, musculature and skeleton. It participates in an ancient signalling pathway also found in insects and worms. Nevertheless, the main practical application of BMPs is for stimulating repair of bone, and their use in humans is currently being assessed. 相似文献
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Guttenbach M Nanda I Brickell PM Godbout R Staeheli P Zehner ZE Schmid M 《Cytogenetics and cell genetics》2000,88(3-4):266-271
Six structural genes encoding ALDH, BMP-2, R-FABP, IFN-gamma, RXR-gamma and VIM were mapped in the chicken by fluorescence in situ hybridization (FISH) using genomic and cDNA clones as probes. The genes were found to be located on four different macrochromosomes: chromosome 1 (IFNG and FABP), chromosome 2 (VIM and ALDH), chromosome 3 (BMP2) and a smaller macrochromosome, most probably chromosome 7 (RXRG). With the exception of IFNG none of the newly mapped sites corresponds to known orthologous regions between chicken and human chromosomes. 相似文献
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Richard M. Briggs Durlin E. Hickok Denise S. Rassier N. Jean Brickell Suzette R. Kakar 《The Western journal of medicine》1980,132(5):466-470
Two private obstetrics-gynecology practices, in adjacent Northwest cities, which employ midlevel nurse practitioners for routine obstetric and gynecologic care were the subject of this study. At site A fees charged by the practitioner were 44 percent less than those for identical services provided by the physician. This was an attempt to pass cost savings directly to patients. At site B, fees were the same for both physician and practitioner, yielding a significant net income to the practice. At this latter site a proportion of the income was passed to patients by not increasing office fees for the years 1975 (when the practitioner was hired) through 1977, during which time the average fees of ten other physicians increased. The study shows that the use of midlevel personnel in private offices is highly cost-effective and profitable. Ideally, this profit can be passed on to patients by reduced overall office fees. 相似文献
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Evidence against expression of an endogenous murine leukemia virus causing cellular resistance to lysis by activated macrophages 总被引:1,自引:0,他引:1
L R Gooding J R Taylor S M Laster K Wehrly B Chesebro P M Brickell D S Latchmann P W Rigby 《Journal of immunology (Baltimore, Md. : 1950)》1989,142(1):257-262
In previous studies we observed that resistance of murine SV40-transformed fibroblast cell lines to cytolysis by activated macrophages was frequently associated with cellular expression of the gp70 of an endogenous ecotropic murine leukemia virus (MuLV). The work described here was initiated to test directly for a causative relationship between MuLV expression and resistance to lysis by macrophages. Northern blot analysis revealed that macrophage-resistant cells contain full length retroviral RNA. A panel of mAb which distinguish among host-range classes of MuLV detected only a non-recombinant ecotropic gp70 in these cells. The ecotropic MuLV from two independently derived macrophage resistant cells were isolated by limiting dilution cloning on Mus dunii fibroblasts. These viruses were then used to infect macrophage-sensitive cell lines and the resultant MuLV-positive cells tested for sensitivity to macrophage cytolysis. The MuLV-infected lines remained highly sensitive to macrophage lysis despite their high levels of cell surface gp70 and release of infectious MuLV. Thus, although we cannot rule out the possibility that MuLV or a product thereof is necessary for development of macrophage resistance in transformed cells, expression of MuLV per se is not sufficient to create the resistant phenotype. 相似文献