排序方式: 共有7条查询结果,搜索用时 15 毫秒
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Sameith Katrin Amini Saman Groot Koerkamp Marian J. A. van Leenen Dik Brok Mariel Brabers Nathalie Lijnzaad Philip van Hooff Sander R. Benschop Joris J. Lenstra Tineke L. Apweiler Eva van Wageningen Sake Snel Berend Holstege Frank C. P. Kemmeren Patrick 《BMC biology》2015,13(1):1-7
Karrikins are a family of compounds produced by wildfires that can stimulate the germination of dormant seeds of plants from numerous families. Seed plants could have ‘discovered’ karrikins during fire-prone times in the Cretaceous period when flowering plants were evolving rapidly. Recent research suggests that karrikins mimic an unidentified endogenous compound that has roles in seed germination and early plant development. The endogenous signalling compound is presumably not only similar to karrikins, but also to the related strigolactone hormones. 相似文献
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Centromere Binding and a Conserved Role in Chromosome Stability for SUMO-Dependent Ubiquitin Ligases
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Patrick Kemmeren Katrin Sameith Loes A.L. van de Pasch Joris J. Benschop Tineke L. Lenstra Thanasis Margaritis Eoghan O’Duibhir Eva Apweiler Sake van Wageningen Cheuk W. Ko Sebastiaan van Heesch Mehdi M. Kashani Giannis Ampatziadis-Michailidis Mariel O. Brok Nathalie A.C.H. Brabers Anthony J. Miles Diane Bouwmeester Sander R. van Hooff Harm van Bakel Erik Sluiters Linda V. Bakker Berend Snel Philip Lijnzaad Dik van Leenen Marian J.A. Groot Koerkamp Frank C.P. Holstege 《Cell》2014
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van Wageningen S Kemmeren P Lijnzaad P Margaritis T Benschop JJ de Castro IJ van Leenen D Groot Koerkamp MJ Ko CW Miles AJ Brabers N Brok MO Lenstra TL Fiedler D Fokkens L Aldecoa R Apweiler E Taliadouros V Sameith K van de Pasch LA van Hooff SR Bakker LV Krogan NJ Snel B Holstege FC 《Cell》2010,143(6):991-1004
To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expression were treated as a phenotypic readout. Double mutants with synthetic genetic interactions were included to investigate genetic buffering relationships such as redundancy. Three types of genetic buffering relationships are identified: mixed epistasis, complete redundancy, and quantitative redundancy. In mixed epistasis, the most common buffering relationship, different gene sets respond in different epistatic ways. Mixed epistasis arises from pairs of regulators that have only partial overlap in function and that are coupled by additional regulatory links such as repression of one by the other. Such regulatory modules confer the ability to control different combinations of processes depending on condition or context. These properties likely contribute to the evolutionary maintenance of paralogs and indicate a way in which signaling pathways connect for multiprocess control. 相似文献
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